Sirtuins and Renal Oxidative Stress
Renal failure is a major health problem that is increasing worldwide. To improve clinical outcomes, we need to understand the basic mechanisms of kidney disease. Aging is a risk factor for the development and progression of kidney disease. Cells develop an imbalance of oxidants and antioxidants as t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/8/1198 |
| _version_ | 1797524850120589312 |
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| author | Yoshio Ogura Munehiro Kitada Daisuke Koya |
| author_facet | Yoshio Ogura Munehiro Kitada Daisuke Koya |
| author_sort | Yoshio Ogura |
| collection | DOAJ |
| description | Renal failure is a major health problem that is increasing worldwide. To improve clinical outcomes, we need to understand the basic mechanisms of kidney disease. Aging is a risk factor for the development and progression of kidney disease. Cells develop an imbalance of oxidants and antioxidants as they age, resulting in oxidative stress and the development of kidney damage. Calorie restriction (CR) is recognized as a dietary approach that promotes longevity, reduces oxidative stress, and delays the onset of age-related diseases. Sirtuins, a type of nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylase, are considered to be anti-aging molecules, and CR induces their expression. The sirtuin family consists of seven enzymes (Sirt1–7) that are involved in processes and functions related to antioxidant and oxidative stress, such as DNA damage repair and metabolism through histone and protein deacetylation. In fact, a role for sirtuins in the regulation of antioxidants and redox substances has been suggested. Therefore, the activation of sirtuins in the kidney may represent a novel therapeutic strategy to enhancing resistance to many causative factors in kidney disease through the reduction of oxidative stress. In this review, we discuss the relationship between sirtuins and oxidative stress in renal disease. |
| first_indexed | 2024-03-10T09:03:25Z |
| format | Article |
| id | doaj.art-87449464e4054abf92069d714ce7df58 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T09:03:25Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-87449464e4054abf92069d714ce7df582023-11-22T06:35:33ZengMDPI AGAntioxidants2076-39212021-07-01108119810.3390/antiox10081198Sirtuins and Renal Oxidative StressYoshio Ogura0Munehiro Kitada1Daisuke Koya2Department of Diabetology and Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, JapanDepartment of Diabetology and Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, JapanDepartment of Diabetology and Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, JapanRenal failure is a major health problem that is increasing worldwide. To improve clinical outcomes, we need to understand the basic mechanisms of kidney disease. Aging is a risk factor for the development and progression of kidney disease. Cells develop an imbalance of oxidants and antioxidants as they age, resulting in oxidative stress and the development of kidney damage. Calorie restriction (CR) is recognized as a dietary approach that promotes longevity, reduces oxidative stress, and delays the onset of age-related diseases. Sirtuins, a type of nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylase, are considered to be anti-aging molecules, and CR induces their expression. The sirtuin family consists of seven enzymes (Sirt1–7) that are involved in processes and functions related to antioxidant and oxidative stress, such as DNA damage repair and metabolism through histone and protein deacetylation. In fact, a role for sirtuins in the regulation of antioxidants and redox substances has been suggested. Therefore, the activation of sirtuins in the kidney may represent a novel therapeutic strategy to enhancing resistance to many causative factors in kidney disease through the reduction of oxidative stress. In this review, we discuss the relationship between sirtuins and oxidative stress in renal disease.https://www.mdpi.com/2076-3921/10/8/1198chronic kidney disease (CKD)oxidative stresssirtuins |
| spellingShingle | Yoshio Ogura Munehiro Kitada Daisuke Koya Sirtuins and Renal Oxidative Stress Antioxidants chronic kidney disease (CKD) oxidative stress sirtuins |
| title | Sirtuins and Renal Oxidative Stress |
| title_full | Sirtuins and Renal Oxidative Stress |
| title_fullStr | Sirtuins and Renal Oxidative Stress |
| title_full_unstemmed | Sirtuins and Renal Oxidative Stress |
| title_short | Sirtuins and Renal Oxidative Stress |
| title_sort | sirtuins and renal oxidative stress |
| topic | chronic kidney disease (CKD) oxidative stress sirtuins |
| url | https://www.mdpi.com/2076-3921/10/8/1198 |
| work_keys_str_mv | AT yoshioogura sirtuinsandrenaloxidativestress AT munehirokitada sirtuinsandrenaloxidativestress AT daisukekoya sirtuinsandrenaloxidativestress |