Establishment of a population pharmacokinetics model of vancomycin in 94 infants with septicemia and its application in individualized therapy

Establishment of a population pharmacokinetics model of vancomycin in 94 infants with septicemia and its application in individualized therapy

Abstract Background We aim to develop a population pharmacokinetics (PopPK) model of vancomycin for the treatment of septicemia in infants younger than one year. Factors influence of the PK was investigated to optimize vancomycin dosing regimen. Methods The nonlinear mixed effects modelling software...

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Bibliographic Details
Main Authors:	Zhiling Li, Hongjing Li, Chenyu Wang, Zheng Jiao, Feng Xu, Huajun Sun
Format:	Article
Language:	English
Published:	BMC 2021-05-01
Series:	BMC Pharmacology and Toxicology
Subjects:	Infants septicemia Vancomycin Population pharmacokinetic Monte Carlo Individualized administration
Online Access:	https://doi.org/10.1186/s40360-021-00489-8

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