A Review on the Management of Peripheral Neuropathic Pain Following Breast Cancer
Francisco Avila, Ricardo Torres-Guzman, Karla Maita, John P Garcia, Gioacchino D De Sario, Sahar Borna, Olivia A Ho, Antonio J Forte Division of Plastic Surgery, Department of Surgery, Mayo Clinic, Jacksonville, FL, USACorrespondence: Antonio J Forte, Mayo Clinic Florida, 4500 San Pablo Roads, Jacks...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-10-01
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| Series: | Breast Cancer: Targets and Therapy |
| Subjects: | |
| Online Access: | https://www.dovepress.com/a-review-on-the-management-of-peripheral-neuropathic-pain-following-br-peer-reviewed-fulltext-article-BCTT |
| _version_ | 1797643747992797184 |
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| author | Avila F Torres-Guzman R Maita K Garcia JP De Sario GD Borna S Ho OA Forte AJ |
| author_facet | Avila F Torres-Guzman R Maita K Garcia JP De Sario GD Borna S Ho OA Forte AJ |
| author_sort | Avila F |
| collection | DOAJ |
| description | Francisco Avila, Ricardo Torres-Guzman, Karla Maita, John P Garcia, Gioacchino D De Sario, Sahar Borna, Olivia A Ho, Antonio J Forte Division of Plastic Surgery, Department of Surgery, Mayo Clinic, Jacksonville, FL, USACorrespondence: Antonio J Forte, Mayo Clinic Florida, 4500 San Pablo Roads, Jacksonville, FL, 32224, USA, Tel +1 904-953-2073, Email ajvforte@yahoo.com.brAbstract: Postmastectomy pain syndrome (PMPS) is a common and debilitating form of postsurgical pain with neuropathic characteristics, presenting as burning, stabbing, or pulling sensations after mastectomy, lumpectomy, or other breast procedures. With a prevalence of 31%, the risk factors for PMPS include younger age, psychosocial factors, radiotherapy, axillary lymph node dissection, and a history of chronic pain. This review evaluates the pharmacological and surgical options for managing PMPS. Pharmacological treatment options include antidepressants, gabapentinoids, levetiracetam, capsaicin, and topical lidocaine. Procedural and surgical options include fat grafting, nerve blocks, radiofrequency ablation, peripheral nerve surgery, serratus plane block, and botulinum toxin injections. Despite the variety of therapeutic options available for patients, further randomized trials are required to conclude whether these treatments reduce the intensity of neuropathic pain in patients with PMPS. In particular, comparative studies and the inclusion of patients across a range of pain intensities will be essential to developing a treatment algorithm for PMPS. In conclusion, current management for these patients should be tailored to their individual requirements.Keywords: postmastectomy pain syndrome, postsurgical pain, neuropathic pain, neuralgia, breast neoplasms, Mastectomy |
| first_indexed | 2024-03-11T14:20:30Z |
| format | Article |
| id | doaj.art-8747016191ce4a2abbb2a67ecfb36029 |
| institution | Directory Open Access Journal |
| issn | 1179-1314 |
| language | English |
| last_indexed | 2024-03-11T14:20:30Z |
| publishDate | 2023-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Breast Cancer: Targets and Therapy |
| spelling | doaj.art-8747016191ce4a2abbb2a67ecfb360292023-10-31T17:33:54ZengDove Medical PressBreast Cancer: Targets and Therapy1179-13142023-10-01Volume 1576177287711A Review on the Management of Peripheral Neuropathic Pain Following Breast CancerAvila FTorres-Guzman RMaita KGarcia JPDe Sario GDBorna SHo OAForte AJFrancisco Avila, Ricardo Torres-Guzman, Karla Maita, John P Garcia, Gioacchino D De Sario, Sahar Borna, Olivia A Ho, Antonio J Forte Division of Plastic Surgery, Department of Surgery, Mayo Clinic, Jacksonville, FL, USACorrespondence: Antonio J Forte, Mayo Clinic Florida, 4500 San Pablo Roads, Jacksonville, FL, 32224, USA, Tel +1 904-953-2073, Email ajvforte@yahoo.com.brAbstract: Postmastectomy pain syndrome (PMPS) is a common and debilitating form of postsurgical pain with neuropathic characteristics, presenting as burning, stabbing, or pulling sensations after mastectomy, lumpectomy, or other breast procedures. With a prevalence of 31%, the risk factors for PMPS include younger age, psychosocial factors, radiotherapy, axillary lymph node dissection, and a history of chronic pain. This review evaluates the pharmacological and surgical options for managing PMPS. Pharmacological treatment options include antidepressants, gabapentinoids, levetiracetam, capsaicin, and topical lidocaine. Procedural and surgical options include fat grafting, nerve blocks, radiofrequency ablation, peripheral nerve surgery, serratus plane block, and botulinum toxin injections. Despite the variety of therapeutic options available for patients, further randomized trials are required to conclude whether these treatments reduce the intensity of neuropathic pain in patients with PMPS. In particular, comparative studies and the inclusion of patients across a range of pain intensities will be essential to developing a treatment algorithm for PMPS. In conclusion, current management for these patients should be tailored to their individual requirements.Keywords: postmastectomy pain syndrome, postsurgical pain, neuropathic pain, neuralgia, breast neoplasms, Mastectomyhttps://www.dovepress.com/a-review-on-the-management-of-peripheral-neuropathic-pain-following-br-peer-reviewed-fulltext-article-BCTTpostmastectomy pain syndromepostsurgical painneuropathic painneuralgiabreast neoplasmsmastectomy |
| spellingShingle | Avila F Torres-Guzman R Maita K Garcia JP De Sario GD Borna S Ho OA Forte AJ A Review on the Management of Peripheral Neuropathic Pain Following Breast Cancer Breast Cancer: Targets and Therapy postmastectomy pain syndrome postsurgical pain neuropathic pain neuralgia breast neoplasms mastectomy |
| title | A Review on the Management of Peripheral Neuropathic Pain Following Breast Cancer |
| title_full | A Review on the Management of Peripheral Neuropathic Pain Following Breast Cancer |
| title_fullStr | A Review on the Management of Peripheral Neuropathic Pain Following Breast Cancer |
| title_full_unstemmed | A Review on the Management of Peripheral Neuropathic Pain Following Breast Cancer |
| title_short | A Review on the Management of Peripheral Neuropathic Pain Following Breast Cancer |
| title_sort | review on the management of peripheral neuropathic pain following breast cancer |
| topic | postmastectomy pain syndrome postsurgical pain neuropathic pain neuralgia breast neoplasms mastectomy |
| url | https://www.dovepress.com/a-review-on-the-management-of-peripheral-neuropathic-pain-following-br-peer-reviewed-fulltext-article-BCTT |
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