3D printing of bio-instructive materials: Toward directing the cell
Fabrication of functional scaffolds for tissue engineering and regenerative medicine applications requires material systems with precise control over cellular performance. 3D printing is a powerful technique to create highly complex and multicomponent structures with well-defined architecture and co...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-01-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X22001773 |
| _version_ | 1797204882453692416 |
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| author | Piotr Stanisław Zieliński Pavan Kumar Reddy Gudeti Timo Rikmanspoel Małgorzata Katarzyna Włodarczyk-Biegun |
| author_facet | Piotr Stanisław Zieliński Pavan Kumar Reddy Gudeti Timo Rikmanspoel Małgorzata Katarzyna Włodarczyk-Biegun |
| author_sort | Piotr Stanisław Zieliński |
| collection | DOAJ |
| description | Fabrication of functional scaffolds for tissue engineering and regenerative medicine applications requires material systems with precise control over cellular performance. 3D printing is a powerful technique to create highly complex and multicomponent structures with well-defined architecture and composition. In this review paper, we explore extrusion-based 3D printing methods (EBP, i.e., Near Field Electrospinning (NFES), Melt Electrowriting (MEW), Fused Deposition Modeling (FDM), and extrusion bioprinting) in terms of their ability to produce scaffolds with bio-instructive properties. These material systems provide spatio-temporal guidance for cells, allowing controlled tissue regeneration and maturation. Multiple physical and biochemical cues introduced to the EBP scaffolds are evaluated in their ability to direct cell alignment, proliferation, differentiation, specific ECM production, and tissue maturation. We indicate that the cues have different impacts depending on the material system, cell type used, or coexistence of multiple cues. Therefore, they must be carefully chosen based on the targeted application. We propose future directions in bio-instructive materials development, including such concepts as metamaterials, hybrid living materials, and 4D printing. The review gathers the knowledge essential for designing new materials with a controlled cellular response, fabrication of advanced engineered tissue, and developing a better understanding of cell biology, especially in response to the biomaterial. |
| first_indexed | 2024-04-11T20:32:27Z |
| format | Article |
| id | doaj.art-87471b40b83e40ee93788634fc37f9e6 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:42:17Z |
| publishDate | 2023-01-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-87471b40b83e40ee93788634fc37f9e62024-04-16T15:30:39ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2023-01-01192923273D printing of bio-instructive materials: Toward directing the cellPiotr Stanisław Zieliński0Pavan Kumar Reddy Gudeti1Timo Rikmanspoel2Małgorzata Katarzyna Włodarczyk-Biegun3Polymer Science, Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, the NetherlandsBiotechnology Centre, The Silesian University of Technology, B. Krzywoustego 8, 44-100, Gliwice, PolandPolymer Science, Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, the NetherlandsPolymer Science, Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, the Netherlands; Biotechnology Centre, The Silesian University of Technology, B. Krzywoustego 8, 44-100, Gliwice, Poland; Corresponding author. Biotechnology Centre, The Silesian University of Technology, B. Krzywoustego 8, 44-100, Gliwice, Poland.Fabrication of functional scaffolds for tissue engineering and regenerative medicine applications requires material systems with precise control over cellular performance. 3D printing is a powerful technique to create highly complex and multicomponent structures with well-defined architecture and composition. In this review paper, we explore extrusion-based 3D printing methods (EBP, i.e., Near Field Electrospinning (NFES), Melt Electrowriting (MEW), Fused Deposition Modeling (FDM), and extrusion bioprinting) in terms of their ability to produce scaffolds with bio-instructive properties. These material systems provide spatio-temporal guidance for cells, allowing controlled tissue regeneration and maturation. Multiple physical and biochemical cues introduced to the EBP scaffolds are evaluated in their ability to direct cell alignment, proliferation, differentiation, specific ECM production, and tissue maturation. We indicate that the cues have different impacts depending on the material system, cell type used, or coexistence of multiple cues. Therefore, they must be carefully chosen based on the targeted application. We propose future directions in bio-instructive materials development, including such concepts as metamaterials, hybrid living materials, and 4D printing. The review gathers the knowledge essential for designing new materials with a controlled cellular response, fabrication of advanced engineered tissue, and developing a better understanding of cell biology, especially in response to the biomaterial.http://www.sciencedirect.com/science/article/pii/S2452199X22001773Tissue engineeringAdditive manufacturingMelt electrowriting3D scaffoldCell differentiationBiomaterials |
| spellingShingle | Piotr Stanisław Zieliński Pavan Kumar Reddy Gudeti Timo Rikmanspoel Małgorzata Katarzyna Włodarczyk-Biegun 3D printing of bio-instructive materials: Toward directing the cell Bioactive Materials Tissue engineering Additive manufacturing Melt electrowriting 3D scaffold Cell differentiation Biomaterials |
| title | 3D printing of bio-instructive materials: Toward directing the cell |
| title_full | 3D printing of bio-instructive materials: Toward directing the cell |
| title_fullStr | 3D printing of bio-instructive materials: Toward directing the cell |
| title_full_unstemmed | 3D printing of bio-instructive materials: Toward directing the cell |
| title_short | 3D printing of bio-instructive materials: Toward directing the cell |
| title_sort | 3d printing of bio instructive materials toward directing the cell |
| topic | Tissue engineering Additive manufacturing Melt electrowriting 3D scaffold Cell differentiation Biomaterials |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X22001773 |
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