Effect of a homeopathic drug, Chelidonium, in amelioration of p-DAB induced hepatocarcinogenesis in mice
<p>Abstract</p> <p>Background</p> <p>Crude extracts of <it>Chelidonium majus</it>, and also purified compounds derived from crude extracts of this plant, have been reported to exhibit anti-viral, anti-inflammatory, anti-tumor and anti-microbial properties bo...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2002-04-01
|
| Series: | BMC Complementary and Alternative Medicine |
| Online Access: | http://www.biomedcentral.com/1472-6882/2/4 |
| _version_ | 1818807935829016576 |
|---|---|
| author | Khuda-Bukhsh Anisur Biswas Surjyo |
| author_facet | Khuda-Bukhsh Anisur Biswas Surjyo |
| author_sort | Khuda-Bukhsh Anisur |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Crude extracts of <it>Chelidonium majus</it>, and also purified compounds derived from crude extracts of this plant, have been reported to exhibit anti-viral, anti-inflammatory, anti-tumor and anti-microbial properties both <it>in vitro</it> and <it>in vivo.</it> Chelidonium is a homeopathic drug routinely used against various liver disorders including cancer in humans. Two potencies of Chelidonium (Ch-30, Ch-200) have been tested for their possible anti-tumor and enzyme modulating activities in liver and anti-clastogenic effects during p-DAB-induced hepatocarcinogenesis in mice compared to suitable controls.</p> <p>Methods</p> <p>Several cytogenetic and enzymatic protocols were used at three fixation intervals; at 60 days, 90 days and 120 days of treatment. Different sets of healthy mice were fed: i) hepatocarcinogen, p-DAB plus phenobarbital (PB), ii) only PB, iii) neither p-DAB nor PB (normal control). One set of mice fed with p-DAB plus PB was also fed Ch-30 (iv) and another set Ch-200 (v). All standard currently used methods were adopted for cytogenetical preparations and for the enzyme assays.</p> <p>Results</p> <p>All group (i) mice developed tumors in liver at all fixation intervals, while none of group (ii) and (iii) mice developed any tumors. About 40% mice in group (iv) and group (v) did not show tumor nodules in their liver. Feeding of Chelidonium to group (iv) and (v) mice reduced genotoxic effects to a significant extent (p < 0.05 to p < 0.001).</p> <p>Conclusion</p> <p>The homeopathic drug Chelidonium exhibited anti-tumor and anti-genotoxic activities and also favorably modulated activities of some marker enzymes. Microdoses of Chelidonium may be effectively used in combating liver cancer.</p> |
| first_indexed | 2024-12-18T19:33:34Z |
| format | Article |
| id | doaj.art-8747a35e18824558bc5a619a997543ce |
| institution | Directory Open Access Journal |
| issn | 1472-6882 |
| language | English |
| last_indexed | 2024-12-18T19:33:34Z |
| publishDate | 2002-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Complementary and Alternative Medicine |
| spelling | doaj.art-8747a35e18824558bc5a619a997543ce2022-12-21T20:55:40ZengBMCBMC Complementary and Alternative Medicine1472-68822002-04-0121410.1186/1472-6882-2-4Effect of a homeopathic drug, Chelidonium, in amelioration of p-DAB induced hepatocarcinogenesis in miceKhuda-Bukhsh AnisurBiswas Surjyo<p>Abstract</p> <p>Background</p> <p>Crude extracts of <it>Chelidonium majus</it>, and also purified compounds derived from crude extracts of this plant, have been reported to exhibit anti-viral, anti-inflammatory, anti-tumor and anti-microbial properties both <it>in vitro</it> and <it>in vivo.</it> Chelidonium is a homeopathic drug routinely used against various liver disorders including cancer in humans. Two potencies of Chelidonium (Ch-30, Ch-200) have been tested for their possible anti-tumor and enzyme modulating activities in liver and anti-clastogenic effects during p-DAB-induced hepatocarcinogenesis in mice compared to suitable controls.</p> <p>Methods</p> <p>Several cytogenetic and enzymatic protocols were used at three fixation intervals; at 60 days, 90 days and 120 days of treatment. Different sets of healthy mice were fed: i) hepatocarcinogen, p-DAB plus phenobarbital (PB), ii) only PB, iii) neither p-DAB nor PB (normal control). One set of mice fed with p-DAB plus PB was also fed Ch-30 (iv) and another set Ch-200 (v). All standard currently used methods were adopted for cytogenetical preparations and for the enzyme assays.</p> <p>Results</p> <p>All group (i) mice developed tumors in liver at all fixation intervals, while none of group (ii) and (iii) mice developed any tumors. About 40% mice in group (iv) and group (v) did not show tumor nodules in their liver. Feeding of Chelidonium to group (iv) and (v) mice reduced genotoxic effects to a significant extent (p < 0.05 to p < 0.001).</p> <p>Conclusion</p> <p>The homeopathic drug Chelidonium exhibited anti-tumor and anti-genotoxic activities and also favorably modulated activities of some marker enzymes. Microdoses of Chelidonium may be effectively used in combating liver cancer.</p>http://www.biomedcentral.com/1472-6882/2/4 |
| spellingShingle | Khuda-Bukhsh Anisur Biswas Surjyo Effect of a homeopathic drug, Chelidonium, in amelioration of p-DAB induced hepatocarcinogenesis in mice BMC Complementary and Alternative Medicine |
| title | Effect of a homeopathic drug, Chelidonium, in amelioration of p-DAB induced hepatocarcinogenesis in mice |
| title_full | Effect of a homeopathic drug, Chelidonium, in amelioration of p-DAB induced hepatocarcinogenesis in mice |
| title_fullStr | Effect of a homeopathic drug, Chelidonium, in amelioration of p-DAB induced hepatocarcinogenesis in mice |
| title_full_unstemmed | Effect of a homeopathic drug, Chelidonium, in amelioration of p-DAB induced hepatocarcinogenesis in mice |
| title_short | Effect of a homeopathic drug, Chelidonium, in amelioration of p-DAB induced hepatocarcinogenesis in mice |
| title_sort | effect of a homeopathic drug chelidonium in amelioration of p dab induced hepatocarcinogenesis in mice |
| url | http://www.biomedcentral.com/1472-6882/2/4 |
| work_keys_str_mv | AT khudabukhshanisur effectofahomeopathicdrugchelidoniuminameliorationofpdabinducedhepatocarcinogenesisinmice AT biswassurjyo effectofahomeopathicdrugchelidoniuminameliorationofpdabinducedhepatocarcinogenesisinmice |