Sensor-Integrated Microfluidic Approaches for Liquid Biopsies Applications in Early Detection of Cancer
Cancer represents one of the conditions with the most causes of death worldwide. Common methods for its diagnosis are based on tissue biopsies—the extraction of tissue from the primary tumor, which is used for its histological analysis. However, this technique represents a risk for the pat...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-02-01
|
| Series: | Sensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8220/20/5/1317 |
| _version_ | 1811307893933211648 |
|---|---|
| author | Jessica Sierra José Marrugo-Ramírez Romen Rodriguez-Trujillo Mònica Mir Josep Samitier |
| author_facet | Jessica Sierra José Marrugo-Ramírez Romen Rodriguez-Trujillo Mònica Mir Josep Samitier |
| author_sort | Jessica Sierra |
| collection | DOAJ |
| description | Cancer represents one of the conditions with the most causes of death worldwide. Common methods for its diagnosis are based on tissue biopsies—the extraction of tissue from the primary tumor, which is used for its histological analysis. However, this technique represents a risk for the patient, along with being expensive and time-consuming and so it cannot be frequently used to follow the progress of the disease. Liquid biopsy is a new cancer diagnostic alternative, which allows the analysis of the molecular information of the solid tumors via a body fluid draw. This fluid-based diagnostic method displays relevant advantages, including its minimal invasiveness, lower risk, use as often as required, it can be analyzed with the use of microfluidic-based platforms with low consumption of reagent, and it does not require specialized personnel and expensive equipment for the diagnosis. In recent years, the integration of sensors in microfluidics lab-on-a-chip devices was performed for liquid biopsies applications, granting significant advantages in the separation and detection of circulating tumor nucleic acids (ctNAs), circulating tumor cells (CTCs) and exosomes. The improvements in isolation and detection technologies offer increasingly sensitive and selective equipment’s, and the integration in microfluidic devices provides a better characterization and analysis of these biomarkers. These fully integrated systems will facilitate the generation of fully automatized platforms at low-cost for compact cancer diagnosis systems at an early stage and for the prediction and prognosis of cancer treatment through the biomarkers for personalized tumor analysis. |
| first_indexed | 2024-04-13T09:12:16Z |
| format | Article |
| id | doaj.art-874982ff5435456e9def136baacb1410 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-13T09:12:16Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-874982ff5435456e9def136baacb14102022-12-22T02:52:51ZengMDPI AGSensors1424-82202020-02-01205131710.3390/s20051317s20051317Sensor-Integrated Microfluidic Approaches for Liquid Biopsies Applications in Early Detection of CancerJessica Sierra0José Marrugo-Ramírez1Romen Rodriguez-Trujillo2Mònica Mir3Josep Samitier4Nanobioengineering Group, Institute for Bioengineering of Catalonia (IBEC) Barcelona Institute of Science and Technology (BIST), 12 Baldiri Reixac 15-21, 08028 Barcelona, SpainDepartment of Electronics and Biomedical Engineering, University of Barcelona, Martí i Franquès 1, 08028 Barcelona, SpainNanobioengineering Group, Institute for Bioengineering of Catalonia (IBEC) Barcelona Institute of Science and Technology (BIST), 12 Baldiri Reixac 15-21, 08028 Barcelona, SpainNanobioengineering Group, Institute for Bioengineering of Catalonia (IBEC) Barcelona Institute of Science and Technology (BIST), 12 Baldiri Reixac 15-21, 08028 Barcelona, SpainNanobioengineering Group, Institute for Bioengineering of Catalonia (IBEC) Barcelona Institute of Science and Technology (BIST), 12 Baldiri Reixac 15-21, 08028 Barcelona, SpainCancer represents one of the conditions with the most causes of death worldwide. Common methods for its diagnosis are based on tissue biopsies—the extraction of tissue from the primary tumor, which is used for its histological analysis. However, this technique represents a risk for the patient, along with being expensive and time-consuming and so it cannot be frequently used to follow the progress of the disease. Liquid biopsy is a new cancer diagnostic alternative, which allows the analysis of the molecular information of the solid tumors via a body fluid draw. This fluid-based diagnostic method displays relevant advantages, including its minimal invasiveness, lower risk, use as often as required, it can be analyzed with the use of microfluidic-based platforms with low consumption of reagent, and it does not require specialized personnel and expensive equipment for the diagnosis. In recent years, the integration of sensors in microfluidics lab-on-a-chip devices was performed for liquid biopsies applications, granting significant advantages in the separation and detection of circulating tumor nucleic acids (ctNAs), circulating tumor cells (CTCs) and exosomes. The improvements in isolation and detection technologies offer increasingly sensitive and selective equipment’s, and the integration in microfluidic devices provides a better characterization and analysis of these biomarkers. These fully integrated systems will facilitate the generation of fully automatized platforms at low-cost for compact cancer diagnosis systems at an early stage and for the prediction and prognosis of cancer treatment through the biomarkers for personalized tumor analysis.https://www.mdpi.com/1424-8220/20/5/1317cancercirculant tumor dna (ctdna)liquid biopsymicrofluidicsensorscirculant tumor cells (ctc)exosomes |
| spellingShingle | Jessica Sierra José Marrugo-Ramírez Romen Rodriguez-Trujillo Mònica Mir Josep Samitier Sensor-Integrated Microfluidic Approaches for Liquid Biopsies Applications in Early Detection of Cancer Sensors cancer circulant tumor dna (ctdna) liquid biopsy microfluidic sensors circulant tumor cells (ctc) exosomes |
| title | Sensor-Integrated Microfluidic Approaches for Liquid Biopsies Applications in Early Detection of Cancer |
| title_full | Sensor-Integrated Microfluidic Approaches for Liquid Biopsies Applications in Early Detection of Cancer |
| title_fullStr | Sensor-Integrated Microfluidic Approaches for Liquid Biopsies Applications in Early Detection of Cancer |
| title_full_unstemmed | Sensor-Integrated Microfluidic Approaches for Liquid Biopsies Applications in Early Detection of Cancer |
| title_short | Sensor-Integrated Microfluidic Approaches for Liquid Biopsies Applications in Early Detection of Cancer |
| title_sort | sensor integrated microfluidic approaches for liquid biopsies applications in early detection of cancer |
| topic | cancer circulant tumor dna (ctdna) liquid biopsy microfluidic sensors circulant tumor cells (ctc) exosomes |
| url | https://www.mdpi.com/1424-8220/20/5/1317 |
| work_keys_str_mv | AT jessicasierra sensorintegratedmicrofluidicapproachesforliquidbiopsiesapplicationsinearlydetectionofcancer AT josemarrugoramirez sensorintegratedmicrofluidicapproachesforliquidbiopsiesapplicationsinearlydetectionofcancer AT romenrodrigueztrujillo sensorintegratedmicrofluidicapproachesforliquidbiopsiesapplicationsinearlydetectionofcancer AT monicamir sensorintegratedmicrofluidicapproachesforliquidbiopsiesapplicationsinearlydetectionofcancer AT josepsamitier sensorintegratedmicrofluidicapproachesforliquidbiopsiesapplicationsinearlydetectionofcancer |