The role of circadian rhythm in osteoporosis; a review
Osteoporosis is characterized by a high incidence rate, with significant effects on people’s lives. The underlying mechanisms are complex, with no treatments for the condition. Recent studies have indicated that melatonin can be used to treat osteoporosis by promoting osteoblast proliferation and di...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.960456/full |
| _version_ | 1811204139053481984 |
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| author | Yihao Tian Jian Ming |
| author_facet | Yihao Tian Jian Ming |
| author_sort | Yihao Tian |
| collection | DOAJ |
| description | Osteoporosis is characterized by a high incidence rate, with significant effects on people’s lives. The underlying mechanisms are complex, with no treatments for the condition. Recent studies have indicated that melatonin can be used to treat osteoporosis by promoting osteoblast proliferation and differentiation, and inhibiting osteoclast differentiation. Specifically, in vivo mechanisms are initiated by stabilizing biological rhythms in bone tissue. In healthy organisms, these biological rhythms are present in bone tissue, and are characterized by bone formation during the day, and bone resorption at night. When this rhythm is disrupted, osteoporosis occurs. Thus, taking appropriate medication at different times of the day could produce different effects on osteoporosis rhythms. In this review, we characterized these processes, and provided treatments and management strategies for individuals with osteoporosis. |
| first_indexed | 2024-04-12T03:07:15Z |
| format | Article |
| id | doaj.art-8749dd75ee4b44a5af305d661897612c |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-12T03:07:15Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-8749dd75ee4b44a5af305d661897612c2022-12-22T03:50:28ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-09-011010.3389/fcell.2022.960456960456The role of circadian rhythm in osteoporosis; a reviewYihao TianJian MingOsteoporosis is characterized by a high incidence rate, with significant effects on people’s lives. The underlying mechanisms are complex, with no treatments for the condition. Recent studies have indicated that melatonin can be used to treat osteoporosis by promoting osteoblast proliferation and differentiation, and inhibiting osteoclast differentiation. Specifically, in vivo mechanisms are initiated by stabilizing biological rhythms in bone tissue. In healthy organisms, these biological rhythms are present in bone tissue, and are characterized by bone formation during the day, and bone resorption at night. When this rhythm is disrupted, osteoporosis occurs. Thus, taking appropriate medication at different times of the day could produce different effects on osteoporosis rhythms. In this review, we characterized these processes, and provided treatments and management strategies for individuals with osteoporosis.https://www.frontiersin.org/articles/10.3389/fcell.2022.960456/fullcircadian rhythmmelatoninosteoclast differentiationcircadian rhythm genesosteoporosis |
| spellingShingle | Yihao Tian Jian Ming The role of circadian rhythm in osteoporosis; a review Frontiers in Cell and Developmental Biology circadian rhythm melatonin osteoclast differentiation circadian rhythm genes osteoporosis |
| title | The role of circadian rhythm in osteoporosis; a review |
| title_full | The role of circadian rhythm in osteoporosis; a review |
| title_fullStr | The role of circadian rhythm in osteoporosis; a review |
| title_full_unstemmed | The role of circadian rhythm in osteoporosis; a review |
| title_short | The role of circadian rhythm in osteoporosis; a review |
| title_sort | role of circadian rhythm in osteoporosis a review |
| topic | circadian rhythm melatonin osteoclast differentiation circadian rhythm genes osteoporosis |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.960456/full |
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