Obesity affects pulmonary function in Japanese adult patients with asthma, but not those without asthma
Abstract Obesity is associated with the severity of asthma, which is characterized by airway obstruction. Pulmonary function testing is one of the important examinations for evaluating airway obstruction. However, the impact of obesity on pulmonary function in patients with asthma is not fully under...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-20924-y |
| _version_ | 1811253564181315584 |
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| author | Hiroki Tashiro Koichiro Takahashi Yuki Kurihara Hironori Sadamatsu Yuki Kuwahara Ryo Tajiri Shinya Kimura Naoko Sueoka-Aragane |
| author_facet | Hiroki Tashiro Koichiro Takahashi Yuki Kurihara Hironori Sadamatsu Yuki Kuwahara Ryo Tajiri Shinya Kimura Naoko Sueoka-Aragane |
| author_sort | Hiroki Tashiro |
| collection | DOAJ |
| description | Abstract Obesity is associated with the severity of asthma, which is characterized by airway obstruction. Pulmonary function testing is one of the important examinations for evaluating airway obstruction. However, the impact of obesity on pulmonary function in patients with asthma is not fully understood. A total of 193 patients with asthma and 2159 patients without asthma who visited Saga University Hospital were investigated retrospectively. Obesity was defined as a body mass index (BMI) greater than 25 kg/m2. Pulmonary functions including forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) were compared between patients with and without asthma, focusing especially on obesity. FVC percent predicted and FEV1 percent predicted were significantly lower in patients with asthma than in those without asthma (p = 0.03, < 0.01 respectively). In patients with asthma, FVC percent predicted and FEV1 percent predicted were significantly lower in patients with obesity than in those without obesity (all p < 0.01). In addition, BMI was negatively correlated with FEV1 (r =− 0.21, p = 0.003) and FVC (r = − 0.15, p = 0.04), along with the percent predicted. On multivariate analysis in patients with asthma, FVC (β [95% confidence interval] 0.12 [0.02–0.22], p = 0.02) and FEV1 (0.13 [0.05–0.22], p < 0.01) were still significantly different between patients with and without obesity. However, these obesity-associated differences were not observed in patients without asthma. Obesity reduces pulmonary function, including FVC and FEV1, in patients with asthma, but not in those without asthma. |
| first_indexed | 2024-04-12T16:54:00Z |
| format | Article |
| id | doaj.art-8749e7c4808c43249501ad35941ee3ca |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T16:54:00Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-8749e7c4808c43249501ad35941ee3ca2022-12-22T03:24:19ZengNature PortfolioScientific Reports2045-23222022-09-0112111010.1038/s41598-022-20924-yObesity affects pulmonary function in Japanese adult patients with asthma, but not those without asthmaHiroki Tashiro0Koichiro Takahashi1Yuki Kurihara2Hironori Sadamatsu3Yuki Kuwahara4Ryo Tajiri5Shinya Kimura6Naoko Sueoka-Aragane7Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine Faculty of Medicine, Saga UniversityDivision of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine Faculty of Medicine, Saga UniversityDivision of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine Faculty of Medicine, Saga UniversityDivision of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine Faculty of Medicine, Saga UniversityDivision of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine Faculty of Medicine, Saga UniversityClinical Research Center, Saga University HospitalDivision of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine Faculty of Medicine, Saga UniversityDivision of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine Faculty of Medicine, Saga UniversityAbstract Obesity is associated with the severity of asthma, which is characterized by airway obstruction. Pulmonary function testing is one of the important examinations for evaluating airway obstruction. However, the impact of obesity on pulmonary function in patients with asthma is not fully understood. A total of 193 patients with asthma and 2159 patients without asthma who visited Saga University Hospital were investigated retrospectively. Obesity was defined as a body mass index (BMI) greater than 25 kg/m2. Pulmonary functions including forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) were compared between patients with and without asthma, focusing especially on obesity. FVC percent predicted and FEV1 percent predicted were significantly lower in patients with asthma than in those without asthma (p = 0.03, < 0.01 respectively). In patients with asthma, FVC percent predicted and FEV1 percent predicted were significantly lower in patients with obesity than in those without obesity (all p < 0.01). In addition, BMI was negatively correlated with FEV1 (r =− 0.21, p = 0.003) and FVC (r = − 0.15, p = 0.04), along with the percent predicted. On multivariate analysis in patients with asthma, FVC (β [95% confidence interval] 0.12 [0.02–0.22], p = 0.02) and FEV1 (0.13 [0.05–0.22], p < 0.01) were still significantly different between patients with and without obesity. However, these obesity-associated differences were not observed in patients without asthma. Obesity reduces pulmonary function, including FVC and FEV1, in patients with asthma, but not in those without asthma.https://doi.org/10.1038/s41598-022-20924-y |
| spellingShingle | Hiroki Tashiro Koichiro Takahashi Yuki Kurihara Hironori Sadamatsu Yuki Kuwahara Ryo Tajiri Shinya Kimura Naoko Sueoka-Aragane Obesity affects pulmonary function in Japanese adult patients with asthma, but not those without asthma Scientific Reports |
| title | Obesity affects pulmonary function in Japanese adult patients with asthma, but not those without asthma |
| title_full | Obesity affects pulmonary function in Japanese adult patients with asthma, but not those without asthma |
| title_fullStr | Obesity affects pulmonary function in Japanese adult patients with asthma, but not those without asthma |
| title_full_unstemmed | Obesity affects pulmonary function in Japanese adult patients with asthma, but not those without asthma |
| title_short | Obesity affects pulmonary function in Japanese adult patients with asthma, but not those without asthma |
| title_sort | obesity affects pulmonary function in japanese adult patients with asthma but not those without asthma |
| url | https://doi.org/10.1038/s41598-022-20924-y |
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