Central Compartment Neck Dissection in Laryngeal and Hypopharyngeal Squamous Cell Carcinoma: Clinical Considerations
Metastatic lymph node involvement represents the most relevant prognostic factor in head and neck squamous cell carcinomas (HNSCCs), invariably affecting overall survival, disease-specific survival, and relapse-free survival. Among HNSCCs, laryngeal and hypopharyngeal cancers are known to be at high...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/3/804 |
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| author | Alberto Deganello Alessandra Ruaro Tommaso Gualtieri Giulia Berretti Vittorio Rampinelli Daniele Borsetto Sabino Russo Paolo Boscolo-Rizzo Marco Ferrari Francesco Bussu |
| author_facet | Alberto Deganello Alessandra Ruaro Tommaso Gualtieri Giulia Berretti Vittorio Rampinelli Daniele Borsetto Sabino Russo Paolo Boscolo-Rizzo Marco Ferrari Francesco Bussu |
| author_sort | Alberto Deganello |
| collection | DOAJ |
| description | Metastatic lymph node involvement represents the most relevant prognostic factor in head and neck squamous cell carcinomas (HNSCCs), invariably affecting overall survival, disease-specific survival, and relapse-free survival. Among HNSCCs, laryngeal and hypopharyngeal cancers are known to be at highest risk to metastasize to the central neck compartment (CNC). However, prevalence and prognostic implications related to the CNC involvement are not well defined yet, and controversies still exist regarding the occult metastasis rate. Guidelines for the management of CNC in laryngeal and hypopharyngeal cancers are vague, resulting in highly variable selection criteria for the central neck dissection among different surgeons and institutions. With this review, the authors intend to reappraise the existing data related to the involvement of CNC in laryngeal and hypopharyngeal malignancies, in the attempt to define the principles of management while highlighting the debated aspects that are lacking in evidence and consensus. Furthermore, as definition and boundaries of the CNC have changed over the years, an up-to-date anatomical–surgical description of the CNC is provided. |
| first_indexed | 2024-03-11T09:50:12Z |
| format | Article |
| id | doaj.art-874c08a73c1646fea82e61ee4758dc14 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T09:50:12Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-874c08a73c1646fea82e61ee4758dc142023-11-16T16:17:27ZengMDPI AGCancers2072-66942023-01-0115380410.3390/cancers15030804Central Compartment Neck Dissection in Laryngeal and Hypopharyngeal Squamous Cell Carcinoma: Clinical ConsiderationsAlberto Deganello0Alessandra Ruaro1Tommaso Gualtieri2Giulia Berretti3Vittorio Rampinelli4Daniele Borsetto5Sabino Russo6Paolo Boscolo-Rizzo7Marco Ferrari8Francesco Bussu9Otolaryngology Head and Neck Surgery Department, IRCCS National Cancer Institute (INT), 20133 Milan, ItalySection of Otolaryngology-Head and Neck Surgery Department, University of Padova, 35128 Padova, ItalyOtolaryngology Head and Neck Surgery Department, University of Brescia, 25123 Brescia, ItalyOtolaryngology Head and Neck Surgery Department, University of Brescia, 25123 Brescia, ItalyOtolaryngology Head and Neck Surgery Department, University of Brescia, 25123 Brescia, ItalyDepartment of ENT Surgery, Cambridge University Hospitals, Cambridge CB2 0QQ, UKOtolaryngology Head and Neck Surgery Department, IRCCS National Cancer Institute (INT) “Giovanni Paolo II”, 70124 Bari, ItalyDepartment of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, 34127 Trieste, ItalySection of Otolaryngology-Head and Neck Surgery Department, University of Padova, 35128 Padova, ItalyOtolaryngology Division, Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, ItalyMetastatic lymph node involvement represents the most relevant prognostic factor in head and neck squamous cell carcinomas (HNSCCs), invariably affecting overall survival, disease-specific survival, and relapse-free survival. Among HNSCCs, laryngeal and hypopharyngeal cancers are known to be at highest risk to metastasize to the central neck compartment (CNC). However, prevalence and prognostic implications related to the CNC involvement are not well defined yet, and controversies still exist regarding the occult metastasis rate. Guidelines for the management of CNC in laryngeal and hypopharyngeal cancers are vague, resulting in highly variable selection criteria for the central neck dissection among different surgeons and institutions. With this review, the authors intend to reappraise the existing data related to the involvement of CNC in laryngeal and hypopharyngeal malignancies, in the attempt to define the principles of management while highlighting the debated aspects that are lacking in evidence and consensus. Furthermore, as definition and boundaries of the CNC have changed over the years, an up-to-date anatomical–surgical description of the CNC is provided.https://www.mdpi.com/2072-6694/15/3/804central neck dissectionparatracheal lymph nodes dissectionlevel VIlaryngeal cancerhypopharyngeal cancersquamous cell carcinoma |
| spellingShingle | Alberto Deganello Alessandra Ruaro Tommaso Gualtieri Giulia Berretti Vittorio Rampinelli Daniele Borsetto Sabino Russo Paolo Boscolo-Rizzo Marco Ferrari Francesco Bussu Central Compartment Neck Dissection in Laryngeal and Hypopharyngeal Squamous Cell Carcinoma: Clinical Considerations Cancers central neck dissection paratracheal lymph nodes dissection level VI laryngeal cancer hypopharyngeal cancer squamous cell carcinoma |
| title | Central Compartment Neck Dissection in Laryngeal and Hypopharyngeal Squamous Cell Carcinoma: Clinical Considerations |
| title_full | Central Compartment Neck Dissection in Laryngeal and Hypopharyngeal Squamous Cell Carcinoma: Clinical Considerations |
| title_fullStr | Central Compartment Neck Dissection in Laryngeal and Hypopharyngeal Squamous Cell Carcinoma: Clinical Considerations |
| title_full_unstemmed | Central Compartment Neck Dissection in Laryngeal and Hypopharyngeal Squamous Cell Carcinoma: Clinical Considerations |
| title_short | Central Compartment Neck Dissection in Laryngeal and Hypopharyngeal Squamous Cell Carcinoma: Clinical Considerations |
| title_sort | central compartment neck dissection in laryngeal and hypopharyngeal squamous cell carcinoma clinical considerations |
| topic | central neck dissection paratracheal lymph nodes dissection level VI laryngeal cancer hypopharyngeal cancer squamous cell carcinoma |
| url | https://www.mdpi.com/2072-6694/15/3/804 |
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