Mutation of the galectin‐3 glycan‐binding domain (Lgals3‐R200S) enhances cortical bone expansion in male mice and trabecular bone mass in female mice

Mutation of the galectin‐3 glycan‐binding domain (Lgals3‐R200S) enhances cortical bone expansion in male mice and trabecular bone mass in female mice

We previously observed that genomic loss of galectin‐3 (Gal‐3; encoded by Lgals3) in mice has a significant protective effect on age‐related bone loss. Gal‐3 has both intracellular and extracellular functionality, and we wanted to assess whether the affect we observed in the Lgals3 knockout (KO) mic...

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Bibliographic Details
Main Authors: Kevin A. Maupin, Cassandra R. Diegel, Payton D. Stevens, Daniel Dick, VAI Vivarium and Transgenic Core, Bart O. Williams
Format: Article
Language:English
Published: Wiley 2022-10-01
Series:FEBS Open Bio
Subjects:
bone μCT
CRISPR/Cas9
galectin
genetic animal models
sexual dimorphism
Online Access:https://doi.org/10.1002/2211-5463.13483

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