| Summary: | Background. Pollinosis (hay fever) is a widespread disease in Russia. Often the
cause of pollinosis is allergens of weeds, among which ragweed (Ambrosia artemisiifolia,
Ambrosia trifida) and wormwood predominate. The purpose of the study was to evaluate
the spectrum of sensitization to different types of ragweed in Samara, as well as the effectiveness
of allergen immunotherapy, depending on the patient’s IgE profile. Materials and methods. Sensitisation to weeds was evaluated retrospectively based on the results of skin
prick-tests. The determination of allergocomponents (Amb a 1 and Аmb.trifida) was carried
out using the ImmunoCAP ISAC diagnostic test system (Sweden). Patients with confirmed
sensitization to ragweed tridividual and lack of IgE to Amb a 1 were treated with allergen
immunotherapy with ragweed allergoid preseason. Results. More than half of the patients
suffering from pollinosis in Samara are sensitized to ragweed. In case of negative CP with
the allergen Ambrosia artemisiifolia, positive IgE-AT to ambrosia are detected in 79.5 % of
cases. Against the background of allergen immunotherapy during the ragweed flowering
season, most patients noted an improvement in their condition. At the same time, there were
no excellent results of allergen immunotherapy. Conclusions. A comprehensive examination
for different types of ragweed, a study of IgE-AT to Ambrosia trifida for the diagnosis
of ragweed pollinosis is necessary. When conducting allergen immunotherapy with the
ragweed allergen, the patient’s IgE profile and the effect of different types of ragweed on
the results of immunotherapy should be taken into account.
|
|---|