Value of Coagulation and Fibrinolysis Biomarker in Lung Cancer Patients with Thromboembolism
Background and objective Coagulation and fibrinolysis biomarkers can effectively reflect the dysfunction of coagulation and anticoagulation system, and the changes of their levels were closely related to the hypercoagulable status. The aim of this study is to study the variation tendency of these co...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | zho |
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2018-08-01
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| Series: | Chinese Journal of Lung Cancer |
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| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2018.08.03 |
| _version_ | 1818412779460100096 |
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| author | Yang FU Yumei LIU Yaxiong JIN Hong JIANG |
| author_facet | Yang FU Yumei LIU Yaxiong JIN Hong JIANG |
| author_sort | Yang FU |
| collection | DOAJ |
| description | Background and objective Coagulation and fibrinolysis biomarkers can effectively reflect the dysfunction of coagulation and anticoagulation system, and the changes of their levels were closely related to the hypercoagulable status. The aim of this study is to study the variation tendency of these coagulation and fibrinolysis markers and explore the diagnosis power and clinical value of these biomarker for thrombosis in postoperative lung cancer patients with deep vein catheterization. Methods We selected 118 postoperative lung cancer patients with deep vein catheterization including 29 patients with thromboembolism and 89 patients in control group. Coagulation and fibrinolysis parameters [thrombomodulin (TM)/thrombin-antithrombin complex (TAT)/α2-plasmin inhibitor-plasmin complexes (PIC)/tissue plasminogen activator-inhibitor complexes (t-PAIC)] and traditional coagulation time[prothrombintime (PT)/activated partial thrombo plastin time(APTT)/thrombintime (TT)/fibrinogen (FIB)/antithrombin III (ATIII)/fibrinogen degradation products (FDP)/D-Dimer (D-D)] were detected in both groups. We analyzed the variation tendency of these biomarkers and figured out the diagnosis powerfor thrombosis. Results A statistically significant difference was available on the value of TM, TAT, PIC, t-PAIC, D-D, FDP between thrombosis group and non-thrombosis group (P<0.05). TM, TAT, PIC, t-PAIC, D-D, FDP performed with an AUC of 0.770, 0.771, 0.669, 0.671, 0.819, 0.816, respectively (P<0.05). Conclusion An enhanced coagulation and fibrinolysis activity existed in lung cancer patients with deep vein catheterization after surgery, and early detection of coagulation and fibrinolytic biomarkers could prevent thrombosis and reduce postoperative thrombosis complications in patients with lung cancer. |
| first_indexed | 2024-12-14T10:52:44Z |
| format | Article |
| id | doaj.art-87549d26d2c041b18ac14b4c88e96f02 |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-12-14T10:52:44Z |
| publishDate | 2018-08-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-87549d26d2c041b18ac14b4c88e96f022022-12-21T23:05:06ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872018-08-0121858358710.3779/j.issn.1009-3419.2018.08.03Value of Coagulation and Fibrinolysis Biomarker in Lung Cancer Patients with ThromboembolismYang FU0Yumei LIU1Yaxiong JIN2Hong JIANG3Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, ChinaBackground and objective Coagulation and fibrinolysis biomarkers can effectively reflect the dysfunction of coagulation and anticoagulation system, and the changes of their levels were closely related to the hypercoagulable status. The aim of this study is to study the variation tendency of these coagulation and fibrinolysis markers and explore the diagnosis power and clinical value of these biomarker for thrombosis in postoperative lung cancer patients with deep vein catheterization. Methods We selected 118 postoperative lung cancer patients with deep vein catheterization including 29 patients with thromboembolism and 89 patients in control group. Coagulation and fibrinolysis parameters [thrombomodulin (TM)/thrombin-antithrombin complex (TAT)/α2-plasmin inhibitor-plasmin complexes (PIC)/tissue plasminogen activator-inhibitor complexes (t-PAIC)] and traditional coagulation time[prothrombintime (PT)/activated partial thrombo plastin time(APTT)/thrombintime (TT)/fibrinogen (FIB)/antithrombin III (ATIII)/fibrinogen degradation products (FDP)/D-Dimer (D-D)] were detected in both groups. We analyzed the variation tendency of these biomarkers and figured out the diagnosis powerfor thrombosis. Results A statistically significant difference was available on the value of TM, TAT, PIC, t-PAIC, D-D, FDP between thrombosis group and non-thrombosis group (P<0.05). TM, TAT, PIC, t-PAIC, D-D, FDP performed with an AUC of 0.770, 0.771, 0.669, 0.671, 0.819, 0.816, respectively (P<0.05). Conclusion An enhanced coagulation and fibrinolysis activity existed in lung cancer patients with deep vein catheterization after surgery, and early detection of coagulation and fibrinolytic biomarkers could prevent thrombosis and reduce postoperative thrombosis complications in patients with lung cancer.http://dx.doi.org/10.3779/j.issn.1009-3419.2018.08.03ThrombosisLung neoplasmsCoagulation biomarkerFibrinolysis biomarkerDiagnosis power |
| spellingShingle | Yang FU Yumei LIU Yaxiong JIN Hong JIANG Value of Coagulation and Fibrinolysis Biomarker in Lung Cancer Patients with Thromboembolism Chinese Journal of Lung Cancer Thrombosis Lung neoplasms Coagulation biomarker Fibrinolysis biomarker Diagnosis power |
| title | Value of Coagulation and Fibrinolysis Biomarker in Lung Cancer Patients with Thromboembolism |
| title_full | Value of Coagulation and Fibrinolysis Biomarker in Lung Cancer Patients with Thromboembolism |
| title_fullStr | Value of Coagulation and Fibrinolysis Biomarker in Lung Cancer Patients with Thromboembolism |
| title_full_unstemmed | Value of Coagulation and Fibrinolysis Biomarker in Lung Cancer Patients with Thromboembolism |
| title_short | Value of Coagulation and Fibrinolysis Biomarker in Lung Cancer Patients with Thromboembolism |
| title_sort | value of coagulation and fibrinolysis biomarker in lung cancer patients with thromboembolism |
| topic | Thrombosis Lung neoplasms Coagulation biomarker Fibrinolysis biomarker Diagnosis power |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2018.08.03 |
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