Ferroptosis, necroptosis and cuproptosis: Novel forms of regulated cell death in diabetic cardiomyopathy
Diabetes is a common chronic metabolic disease, and its incidence continues to increase year after year. Diabetic patients mainly die from various complications, with the most common being diabetic cardiomyopathy. However, the detection rate of diabetic cardiomyopathy is low in clinical practice, an...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1135723/full |
| _version_ | 1811155437478739968 |
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| author | Dan Ke Zhen Zhang Zhen Zhang Jieting Liu Jieting Liu Peijian Chen Peijian Chen Jialing Li Xinhai Sun Yanhui Chu Yanhui Chu Luxin Li Luxin Li |
| author_facet | Dan Ke Zhen Zhang Zhen Zhang Jieting Liu Jieting Liu Peijian Chen Peijian Chen Jialing Li Xinhai Sun Yanhui Chu Yanhui Chu Luxin Li Luxin Li |
| author_sort | Dan Ke |
| collection | DOAJ |
| description | Diabetes is a common chronic metabolic disease, and its incidence continues to increase year after year. Diabetic patients mainly die from various complications, with the most common being diabetic cardiomyopathy. However, the detection rate of diabetic cardiomyopathy is low in clinical practice, and targeted treatment is lacking. Recently, a large number of studies have confirmed that myocardial cell death in diabetic cardiomyopathy involves pyroptosis, apoptosis, necrosis, ferroptosis, necroptosis, cuproptosis, cellular burial, and other processes. Most importantly, numerous animal studies have shown that the onset and progression of diabetic cardiomyopathy can be mitigated by inhibiting these regulatory cell death processes, such as by utilizing inhibitors, chelators, or genetic manipulation. Therefore, we review the role of ferroptosis, necroptosis, and cuproptosis, three novel forms of cell death in diabetic cardiomyopathy, searching for possible targets, and analyzing the corresponding therapeutic approaches to these targets. |
| first_indexed | 2024-04-10T04:34:00Z |
| format | Article |
| id | doaj.art-8754d4f0a5834b74b90935e8ab754b0f |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-10T04:34:00Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-8754d4f0a5834b74b90935e8ab754b0f2023-03-10T05:30:49ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-03-011010.3389/fcvm.2023.11357231135723Ferroptosis, necroptosis and cuproptosis: Novel forms of regulated cell death in diabetic cardiomyopathyDan Ke0Zhen Zhang1Zhen Zhang2Jieting Liu3Jieting Liu4Peijian Chen5Peijian Chen6Jialing Li7Xinhai Sun8Yanhui Chu9Yanhui Chu10Luxin Li11Luxin Li12College of Life Sciences, Mudanjiang Medical University, Mudanjiang, ChinaHeilongjiang Key Laboratory of Anti-Fibrosis Biotherapy, Mudanjiang Medical University, Mudanjiang, ChinaSchool of First Clinical Medical College, Mudanjiang Medical University, Mudanjiang, ChinaCollege of Life Sciences, Mudanjiang Medical University, Mudanjiang, ChinaHeilongjiang Key Laboratory of Anti-Fibrosis Biotherapy, Mudanjiang Medical University, Mudanjiang, ChinaCollege of Life Sciences, Mudanjiang Medical University, Mudanjiang, ChinaHeilongjiang Key Laboratory of Anti-Fibrosis Biotherapy, Mudanjiang Medical University, Mudanjiang, ChinaCollege of Life Sciences, Mudanjiang Medical University, Mudanjiang, ChinaDepartment of Thoracic Surgery, Union Hospital, Fujian Medical University, Fuzhou, ChinaCollege of Life Sciences, Mudanjiang Medical University, Mudanjiang, ChinaHeilongjiang Key Laboratory of Anti-Fibrosis Biotherapy, Mudanjiang Medical University, Mudanjiang, ChinaCollege of Life Sciences, Mudanjiang Medical University, Mudanjiang, ChinaHeilongjiang Key Laboratory of Anti-Fibrosis Biotherapy, Mudanjiang Medical University, Mudanjiang, ChinaDiabetes is a common chronic metabolic disease, and its incidence continues to increase year after year. Diabetic patients mainly die from various complications, with the most common being diabetic cardiomyopathy. However, the detection rate of diabetic cardiomyopathy is low in clinical practice, and targeted treatment is lacking. Recently, a large number of studies have confirmed that myocardial cell death in diabetic cardiomyopathy involves pyroptosis, apoptosis, necrosis, ferroptosis, necroptosis, cuproptosis, cellular burial, and other processes. Most importantly, numerous animal studies have shown that the onset and progression of diabetic cardiomyopathy can be mitigated by inhibiting these regulatory cell death processes, such as by utilizing inhibitors, chelators, or genetic manipulation. Therefore, we review the role of ferroptosis, necroptosis, and cuproptosis, three novel forms of cell death in diabetic cardiomyopathy, searching for possible targets, and analyzing the corresponding therapeutic approaches to these targets.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1135723/fulldiabetic cardiomyopathyferroptosisnecroptosiscuproptosisregulatory cell death |
| spellingShingle | Dan Ke Zhen Zhang Zhen Zhang Jieting Liu Jieting Liu Peijian Chen Peijian Chen Jialing Li Xinhai Sun Yanhui Chu Yanhui Chu Luxin Li Luxin Li Ferroptosis, necroptosis and cuproptosis: Novel forms of regulated cell death in diabetic cardiomyopathy Frontiers in Cardiovascular Medicine diabetic cardiomyopathy ferroptosis necroptosis cuproptosis regulatory cell death |
| title | Ferroptosis, necroptosis and cuproptosis: Novel forms of regulated cell death in diabetic cardiomyopathy |
| title_full | Ferroptosis, necroptosis and cuproptosis: Novel forms of regulated cell death in diabetic cardiomyopathy |
| title_fullStr | Ferroptosis, necroptosis and cuproptosis: Novel forms of regulated cell death in diabetic cardiomyopathy |
| title_full_unstemmed | Ferroptosis, necroptosis and cuproptosis: Novel forms of regulated cell death in diabetic cardiomyopathy |
| title_short | Ferroptosis, necroptosis and cuproptosis: Novel forms of regulated cell death in diabetic cardiomyopathy |
| title_sort | ferroptosis necroptosis and cuproptosis novel forms of regulated cell death in diabetic cardiomyopathy |
| topic | diabetic cardiomyopathy ferroptosis necroptosis cuproptosis regulatory cell death |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1135723/full |
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