Temporal Trends of Transcatheter Aortic Valve Implantation over 12 Years: A High-Volume Single-Center Experience
Transcatheter aortic valve replacement (TAVR) has become the mainstay of treatment for patients with severe AS. Since the TAVR population and patients’ outcomes have dramatically changed over the last decade, updated data regarding contemporary practice and trends are pertinent to clinical use. We p...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/17/4962 |
| _version_ | 1797494867761299456 |
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| author | Shir Frydman David Zahler Ilan Merdler Ophir Freund Yacov Shacham Shmuel Banai Ariel Finkelstein Arie Steinvil |
| author_facet | Shir Frydman David Zahler Ilan Merdler Ophir Freund Yacov Shacham Shmuel Banai Ariel Finkelstein Arie Steinvil |
| author_sort | Shir Frydman |
| collection | DOAJ |
| description | Transcatheter aortic valve replacement (TAVR) has become the mainstay of treatment for patients with severe AS. Since the TAVR population and patients’ outcomes have dramatically changed over the last decade, updated data regarding contemporary practice and trends are pertinent to clinical use. We performed a retrospective observational analysis of consecutive patient who underwent TAVR for symptomatic severe AS between the years 2009 and 2021 in a single high-volume center. Patients were divided into four equal time groups based on the procedure date (2009–2012, 2013–2015, 2016–2018 and 2019–2021). A total of 1988 patients were included in this study and divided into four groups, with 321, 482, 565 and 620 patients in groups 1–4, respectively. Significant trends were seen in baseline characteristics of a few parameters, including lower age, lower procedural risk and reduced rates of comorbidity (<i>p</i> for trend < 0.0001 for all factors mentioned above). A shift was seen in the procedural technique with lower balloon pre-dilatation and higher device success rates (<i>p</i> for trend < 0.0001). The post-procedural period changed over the years with fewer pacemaker placements (<i>p</i> < 0.0001) and reduced rates of AKI and post-procedural bleed (<i>p</i> value 0.02 and <0.0001, respectively). Furthermore, overall hospital stay was shortened from 7 ± 7.1 days to 2.3 ± 1.7 (<i>p</i> < 0.0001). Finally, patient follow up revealed reduced mortality rates at 30 days (<i>p</i> < 0.0001) and 1 year (<i>p</i> = 0.013). Multivariate regression revealed that a late implantation date was an independent protector from mortality (HR 0.84, <i>p</i> = 0.002). In conclusion, our study demonstrated that TAVR has become a safer practice over the years with reduced rates of morbidity and mortality. |
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| id | doaj.art-87566d0133e94791a52f4e6902182643 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T01:40:29Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-87566d0133e94791a52f4e69021826432023-11-23T13:25:22ZengMDPI AGJournal of Clinical Medicine2077-03832022-08-011117496210.3390/jcm11174962Temporal Trends of Transcatheter Aortic Valve Implantation over 12 Years: A High-Volume Single-Center ExperienceShir Frydman0David Zahler1Ilan Merdler2Ophir Freund3Yacov Shacham4Shmuel Banai5Ariel Finkelstein6Arie Steinvil7Department of Cardiology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, IsraelDepartment of Cardiology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, IsraelDepartment of Cardiology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, IsraelDepartment of Cardiology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, IsraelDepartment of Cardiology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, IsraelDepartment of Cardiology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, IsraelDepartment of Cardiology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, IsraelDepartment of Cardiology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, IsraelTranscatheter aortic valve replacement (TAVR) has become the mainstay of treatment for patients with severe AS. Since the TAVR population and patients’ outcomes have dramatically changed over the last decade, updated data regarding contemporary practice and trends are pertinent to clinical use. We performed a retrospective observational analysis of consecutive patient who underwent TAVR for symptomatic severe AS between the years 2009 and 2021 in a single high-volume center. Patients were divided into four equal time groups based on the procedure date (2009–2012, 2013–2015, 2016–2018 and 2019–2021). A total of 1988 patients were included in this study and divided into four groups, with 321, 482, 565 and 620 patients in groups 1–4, respectively. Significant trends were seen in baseline characteristics of a few parameters, including lower age, lower procedural risk and reduced rates of comorbidity (<i>p</i> for trend < 0.0001 for all factors mentioned above). A shift was seen in the procedural technique with lower balloon pre-dilatation and higher device success rates (<i>p</i> for trend < 0.0001). The post-procedural period changed over the years with fewer pacemaker placements (<i>p</i> < 0.0001) and reduced rates of AKI and post-procedural bleed (<i>p</i> value 0.02 and <0.0001, respectively). Furthermore, overall hospital stay was shortened from 7 ± 7.1 days to 2.3 ± 1.7 (<i>p</i> < 0.0001). Finally, patient follow up revealed reduced mortality rates at 30 days (<i>p</i> < 0.0001) and 1 year (<i>p</i> = 0.013). Multivariate regression revealed that a late implantation date was an independent protector from mortality (HR 0.84, <i>p</i> = 0.002). In conclusion, our study demonstrated that TAVR has become a safer practice over the years with reduced rates of morbidity and mortality.https://www.mdpi.com/2077-0383/11/17/4962TAVRtrendscomplicationsoutcomesmortality |
| spellingShingle | Shir Frydman David Zahler Ilan Merdler Ophir Freund Yacov Shacham Shmuel Banai Ariel Finkelstein Arie Steinvil Temporal Trends of Transcatheter Aortic Valve Implantation over 12 Years: A High-Volume Single-Center Experience Journal of Clinical Medicine TAVR trends complications outcomes mortality |
| title | Temporal Trends of Transcatheter Aortic Valve Implantation over 12 Years: A High-Volume Single-Center Experience |
| title_full | Temporal Trends of Transcatheter Aortic Valve Implantation over 12 Years: A High-Volume Single-Center Experience |
| title_fullStr | Temporal Trends of Transcatheter Aortic Valve Implantation over 12 Years: A High-Volume Single-Center Experience |
| title_full_unstemmed | Temporal Trends of Transcatheter Aortic Valve Implantation over 12 Years: A High-Volume Single-Center Experience |
| title_short | Temporal Trends of Transcatheter Aortic Valve Implantation over 12 Years: A High-Volume Single-Center Experience |
| title_sort | temporal trends of transcatheter aortic valve implantation over 12 years a high volume single center experience |
| topic | TAVR trends complications outcomes mortality |
| url | https://www.mdpi.com/2077-0383/11/17/4962 |
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