The role of Aquaporins in tumorigenesis: implications for therapeutic development
Abstract Aquaporins (AQPs) are ubiquitous channel proteins that play a critical role in the homeostasis of the cellular environment by allowing the transit of water, chemicals, and ions. They can be found in many different types of cells and organs, including the lungs, eyes, brain, glands, and bloo...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-023-01459-9 |
| _version_ | 1797273821160407040 |
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| author | Arkadyuti Bhattacharjee Ankit Jana Swagato Bhattacharjee Sankalan Mitra Swagata De Badrah S. Alghamdi Mohammad Zubair Alam Ahmad Bakur Mahmoud Zainab Al Shareef Wael M. Abdel-Rahman Chan Woon-Khiong Athanasios Alexiou Marios Papadakis Ghulam Md Ashraf |
| author_facet | Arkadyuti Bhattacharjee Ankit Jana Swagato Bhattacharjee Sankalan Mitra Swagata De Badrah S. Alghamdi Mohammad Zubair Alam Ahmad Bakur Mahmoud Zainab Al Shareef Wael M. Abdel-Rahman Chan Woon-Khiong Athanasios Alexiou Marios Papadakis Ghulam Md Ashraf |
| author_sort | Arkadyuti Bhattacharjee |
| collection | DOAJ |
| description | Abstract Aquaporins (AQPs) are ubiquitous channel proteins that play a critical role in the homeostasis of the cellular environment by allowing the transit of water, chemicals, and ions. They can be found in many different types of cells and organs, including the lungs, eyes, brain, glands, and blood vessels. By controlling the osmotic water flux in processes like cell growth, energy metabolism, migration, adhesion, and proliferation, AQPs are capable of exerting their regulatory influence over a wide range of cellular processes. Tumour cells of varying sources express AQPs significantly, especially in malignant tumours with a high propensity for metastasis. New insights into the roles of AQPs in cell migration and proliferation reinforce the notion that AQPs are crucial players in tumour biology. AQPs have recently been shown to be a powerful tool in the fight against pathogenic antibodies and metastatic cell migration, despite the fact that the molecular processes of aquaporins in pathology are not entirely established. In this review, we shall discuss the several ways in which AQPs are expressed in the body, the unique roles they play in tumorigenesis, and the novel therapeutic approaches that could be adopted to treat carcinoma. |
| first_indexed | 2024-03-07T14:49:42Z |
| format | Article |
| id | doaj.art-875674069e3547f5a99a40c83f5ae2dc |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-03-07T14:49:42Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-875674069e3547f5a99a40c83f5ae2dc2024-03-05T19:47:03ZengBMCCell Communication and Signaling1478-811X2024-02-0122111810.1186/s12964-023-01459-9The role of Aquaporins in tumorigenesis: implications for therapeutic developmentArkadyuti Bhattacharjee0Ankit Jana1Swagato Bhattacharjee2Sankalan Mitra3Swagata De4Badrah S. Alghamdi5Mohammad Zubair Alam6Ahmad Bakur Mahmoud7Zainab Al Shareef8Wael M. Abdel-Rahman9Chan Woon-Khiong10Athanasios Alexiou11Marios Papadakis12Ghulam Md Ashraf13Morningside Graduate School of Biomedical Sciences, University of Massachusetts Medical SchoolDepartment of Biological Sciences, National University of SingaporeKoshKey Sciences Pvt Ltd, Canara Bank LayoutKIIT School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT-DU)Department of English, DDE Unit, The University of BurdwanDepartment of Physiology, Neuroscience Unit, Faculty of Medicine, King Abdulaziz UniversityPre-clinical Research Unit, King Fahd Medical Research Center, King Abdulaziz UniversityCollege of Applied Medical Sciences, Taibah UniversityCollege of Medicine, and Research Institute for Medical and Health Sciences, Department of Basic Medical Sciences, University of SharjahCollege of Health Sciences, and Research Institute for Medical and Health Sciences, Department of Medical Laboratory Sciences, University of SharjahDepartment of Biological Sciences, National University of SingaporeUniversity Centre for Research & Development, Chandigarh UniversityDepartment of Surgery II, University Hospital Witten-Herdecke, Heusnerstrasse 40, University of Witten-HerdeckeCollege of Health Sciences, and Research Institute for Medical and Health Sciences, Department of Medical Laboratory Sciences, University of SharjahAbstract Aquaporins (AQPs) are ubiquitous channel proteins that play a critical role in the homeostasis of the cellular environment by allowing the transit of water, chemicals, and ions. They can be found in many different types of cells and organs, including the lungs, eyes, brain, glands, and blood vessels. By controlling the osmotic water flux in processes like cell growth, energy metabolism, migration, adhesion, and proliferation, AQPs are capable of exerting their regulatory influence over a wide range of cellular processes. Tumour cells of varying sources express AQPs significantly, especially in malignant tumours with a high propensity for metastasis. New insights into the roles of AQPs in cell migration and proliferation reinforce the notion that AQPs are crucial players in tumour biology. AQPs have recently been shown to be a powerful tool in the fight against pathogenic antibodies and metastatic cell migration, despite the fact that the molecular processes of aquaporins in pathology are not entirely established. In this review, we shall discuss the several ways in which AQPs are expressed in the body, the unique roles they play in tumorigenesis, and the novel therapeutic approaches that could be adopted to treat carcinoma.https://doi.org/10.1186/s12964-023-01459-9AquaporinsCancerTumoursWater channelCarcinomaTherapeutic target |
| spellingShingle | Arkadyuti Bhattacharjee Ankit Jana Swagato Bhattacharjee Sankalan Mitra Swagata De Badrah S. Alghamdi Mohammad Zubair Alam Ahmad Bakur Mahmoud Zainab Al Shareef Wael M. Abdel-Rahman Chan Woon-Khiong Athanasios Alexiou Marios Papadakis Ghulam Md Ashraf The role of Aquaporins in tumorigenesis: implications for therapeutic development Cell Communication and Signaling Aquaporins Cancer Tumours Water channel Carcinoma Therapeutic target |
| title | The role of Aquaporins in tumorigenesis: implications for therapeutic development |
| title_full | The role of Aquaporins in tumorigenesis: implications for therapeutic development |
| title_fullStr | The role of Aquaporins in tumorigenesis: implications for therapeutic development |
| title_full_unstemmed | The role of Aquaporins in tumorigenesis: implications for therapeutic development |
| title_short | The role of Aquaporins in tumorigenesis: implications for therapeutic development |
| title_sort | role of aquaporins in tumorigenesis implications for therapeutic development |
| topic | Aquaporins Cancer Tumours Water channel Carcinoma Therapeutic target |
| url | https://doi.org/10.1186/s12964-023-01459-9 |
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