Evolution of substrate specificity in a retained enzyme driven by gene loss
The connection between gene loss and the functional adaptation of retained proteins is still poorly understood. We apply phylogenomics and metabolic modeling to detect bacterial species that are evolving by gene loss, with the finding that Actinomycetaceae genomes from human cavities are undergoing...
Main Authors: | , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2017-03-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/22679 |