In Vitro and In Ovo Evaluation of the Potential Hepatoprotective Effect of Metformin

In Vitro and In Ovo Evaluation of the Potential Hepatoprotective Effect of Metformin

<i>Background and Objectives</i>: Metformin is currently the leading drug of choice for treating type 2 diabetes mellitus, being one of the most widely used drugs worldwide. The beneficial effects of Metformin, however, extend far beyond the reduction of blood glucose. Therefore, this st...

Full description

Bibliographic Details
Main Authors:	Gabriel Veniamin Cozma, Alexandru Apostu, Ioana Macasoi, Cristina Adriana Dehelean, Octavian Marius Cretu, Stefania Dinu, Dan Gaiță, Aniko Manea
Format:	Article
Language:	English
Published:	MDPI AG 2022-05-01
Series:	Medicina
Subjects:	metformin hepatoprotective anti-irritant chorioallantoic membrane HET-CAM
Online Access:	https://www.mdpi.com/1648-9144/58/6/705

Similar Items

Comprehensive in vitro and in ovo assessment of cytotoxicity: Unraveling the impact of sodium fluoride, xylitol, and their synergistic associations in dental products
by: Daniel Breban-Schwarzkopf, et al.
Published: (2024-03-01)

Methotrexate and Cetuximab—Biological Impact on Non-Tumorigenic Models: In Vitro and In Ovo Assessments
by: Andreea M. Kis, et al.
Published: (2022-01-01)

Two Antibiotics, Ampicillin and Tetracycline, Exert Different Effects in HT-29 Colorectal Adenocarcinoma Cells in Terms of Cell Viability and Migration Capacity
by: Emil-Florin Hut, et al.
Published: (2021-07-01)

Eugenol: In Vitro and In Ovo Assessment to Explore Cytotoxic Effects on Osteosarcoma and Oropharyngeal Cancer Cells
by: Robert-Cosmin Racea, et al.
Published: (2023-10-01)

Determination of eye irritation potential of low-irritant products: comparison of in vitro results with the in vivo draize rabbit test
by: Andréa Martins da Nóbrega, et al.
Published: (2012-06-01)

Comparative Toxicological In Vitro and In Ovo Screening of Different Orthodontic Implants Currently Used in Dentistry
by: Camelia A. Szuhanek, et al.
Published: (2020-12-01)

Evaluation of the ameliorative effects of Phyllanthus niruri on the deleterious insecticide imidacloprid in the vital organs of chicken embryos
by: Rekha Khandia, et al.
Published: (2020-10-01)

Retinoblastoma Cell Growth <i>In Vitro</i> and Tumor Formation <i>In Ovo</i>—Influence of Different Culture Conditions
by: Annika Doege, et al.
Published: (2022-03-01)

The Chemical Composition, Antioxidant and Anti-Tyrosinase Activities, and Irritation Properties of Sripanya <i>Punica granatum</i> Peel Extract
by: Nachtharinee Laosirisathian, et al.
Published: (2020-01-01)

Pharmaco-Toxicological Assessment of the Combined Cytotoxic Effects of Digoxin and Betulinic Acid in Melanoma Cells
by: Robert Rednic, et al.
Published: (2022-11-01)

Additive Antiproliferative and Antiangiogenic Effects of Metformin and Pemetrexed in a Non-Small-Cell Lung Cancer Xenograft Model
by: Jiun-Long Wang, et al.
Published: (2021-06-01)

Corrositex®, BCOP and HET-CAM as alternative methods to animal experimentation
by: Edith Cristina Laignier Cazedey, et al.
Published: (2009-12-01)

Successful growth of fresh retinoblastoma cells in chorioallantoic membrane
by: Silvia L. Fialho, et al.
Published: (2020-07-01)

Blocking Studies to Evaluate Receptor-Specific Radioligand Binding in the CAM Model by PET and MR Imaging
by: Jessica Löffler, et al.
Published: (2022-08-01)

Correlations on Phenolic Screening Related to In Vitro and In Ovo Assessment of <i>Ocimum basilicum</i> L. Hydro-Alcoholic Extracts Used as Skin Active Ingredient
by: Alin Faur, et al.
Published: (2020-11-01)

Hepatoprotective Natural Products
by: Omayma A. Eldahshan
Published: (2017-12-01)

In vivo PET/MRI Imaging of the Chorioallantoic Membrane
by: Gordon Winter, et al.
Published: (2020-05-01)

Analysis of drug sensitivity of human high-grade osteosarcoma in a chick chorioallantoic membrane (CAM) model: a proof of principle study
by: Wiebke K. Guder, et al.
Published: (2020-09-01)

Hepatoprotective effect of Helicanthus elastica
by: K. N. Sunil Kumar, et al.
Published: (2016-05-01)

Advances in hepatoprotective medicinal plants research
by: Muhammad Imran Qadir, et al.
Published: (2017-07-01)

Insulin Mimetic Properties of Extracts Prepared from Bellis perennis
by: Renate Haselgrübler, et al.
Published: (2018-10-01)

Evaluación de la irritabilidad en mucosa del adyuvante AFCO1 por el método de HET-CAM
by: Alexander Batista, et al.
Published: (2011-04-01)

Microvascular Experimentation in the Chick Chorioallantoic Membrane as a Model for Screening Angiogenic Agents including from Gene-Modified Cells
by: Donna C. Kennedy, et al.
Published: (2021-12-01)

Tissue damage and embryonic malformation induced by aqueous extract of Pteridium aquilinum on chorioallantoic membrane of chick embryo (CAM)
by: Amanda Leitolis, et al.
Published: (2017-06-01)

Lipopolysaccharides (LPS) Induced Angiogenesis During Chicken Embryogenesis is Abolished by Combined ETA/ETB Receptor Blockade
by: Guang Wang, et al.
Published: (2018-08-01)

Hepatoprotective effect of Chenopodium murale in mice
by: Mohammad Saleem, et al.
Published: (2014-03-01)

PEG-liposomal doxorubicin as a potential agent for canine metastatic osteosarcoma – in vitro and ex ovo studies
by: Walewska Magdalena, et al.
Published: (2023-06-01)

PLGA Nanoparticles for the Intraperitoneal Administration of CBD in the Treatment of Ovarian Cancer: In Vitro and In Ovo Assessment
by: Ana I. Fraguas-Sánchez, et al.
Published: (2020-05-01)

Manipulation of Pattern of Cell Differentiation in a <i>hetR</i> Mutant of <i>Anabaena</i> sp. PCC 7120 by Overexpressing <i>hetZ</i> Alone or with <i>hetP</i>
by: He Zhang, et al.
Published: (2018-11-01)

Studies on Surfactants, Cosurfactants, and Oils for Prospective Use in Formulation of Ketorolac Tromethamine Ophthalmic Nanoemulsions
by: Shahla S. Smail, et al.
Published: (2021-03-01)

Formulation and Characterization of Epalrestat-Loaded Polysorbate 60 Cationic Niosomes for Ocular Delivery
by: Axel Kattar, et al.
Published: (2023-04-01)

Comparison of Quantification of Target-Specific Accumulation of [<sup>18</sup>F]F-siPSMA-14 in the HET-CAM Model and in Mice Using PET/MRI
by: Jessica Löffler, et al.
Published: (2021-08-01)

Formulation and Evaluation of Nano Lipid Carrier-Based Ocular Gel System: Optimization to Antibacterial Activity
by: Sadaf Jamal Gilani, et al.
Published: (2022-04-01)

Development of Ciprofloxacin-Loaded Bilosomes In-Situ Gel for Ocular Delivery: Optimization, In-Vitro Characterization, Ex-Vivo Permeation, and Antimicrobial Study
by: Omar Awad Alsaidan, et al.
Published: (2022-10-01)

Gas Flow Shaping via Novel Modular Nozzle System (MoNoS) Augments kINPen-Mediated Toxicity and Immunogenicity in Tumor Organoids
by: Julia Berner, et al.
Published: (2023-02-01)

Stimulus Responsive Ocular Gentamycin-Ferrying Chitosan Nanoparticles Hydrogel: Formulation Optimization, Ocular Safety and Antibacterial Assessment [Retraction]
by: Alruwaili NK, et al.
Published: (2023-03-01)

Stimulus Responsive Ocular Gentamycin-Ferrying Chitosan Nanoparticles Hydrogel: Formulation Optimization, Ocular Safety and Antibacterial Assessment
by: Alruwaili NK, et al.
Published: (2020-06-01)

Chemical and Biological Analyses of the Essential Oils and Main Constituents of Piper Species
by: Leonor Laura Leon, et al.
Published: (2012-02-01)

Hepatoprotective and antioxidant effects of alcesefoliside from Astragalus monspessulanus
by: Magdalena Kondeva-Burdina, et al.
Published: (2022-03-01)

Hepatoprotective activity of aerial parts of Erythrina crista-galli
by: Nahla A. Ayoub, et al.
Published: (2017-06-01)