Proteomic Analysis of Human iPSC-Derived Neural Stem Cells and Motor Neurons Identifies Proteasome Structural Alterations

Proteomic Analysis of Human iPSC-Derived Neural Stem Cells and Motor Neurons Identifies Proteasome Structural Alterations

Background: Proteins targeted by the ubiquitin proteasome system (UPS) are identified for degradation by the proteasome, which has been implicated in the development of neurodegenerative diseases. Major histocompatibility complex (MHC) molecules present peptides broken down by the proteasome and are...

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Bibliographic Details
Main Authors: Iñaki Álvarez, Adrián Tirado-Herranz, Belén Alvarez-Palomo, Jordi Requena Osete, Michael J. Edel
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Cells
Subjects:
proteomics
induced pluripotent stem cells
differentiation
neural stem cells
motor neurons
26S proteasome
Online Access:https://www.mdpi.com/2073-4409/12/24/2800

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