Inhibition of O-GlcNAcylation Decreases the Cytotoxic Function of Natural Killer Cells

Inhibition of O-GlcNAcylation Decreases the Cytotoxic Function of Natural Killer Cells

Natural killer (NK) cells mediate killing of malignant and virus-infected cells, a property that is explored as a cell therapy approach in the clinic. Various cell intrinsic and extrinsic factors affect NK cell cytotoxic function, and an improved understanding of the mechanism regulating NK cell fun...

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Bibliographic Details
Main Authors: Daniel Feinberg, Parameswaran Ramakrishnan, Derek P. Wong, Abhishek Asthana, Reshmi Parameswaran
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
natural kiiler cells
O-GlcNAc
cytotocixicity
cytokines
post-translation modification
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.841299/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.841299/full

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