A Robust Oxygen Microbubble Radiosensitizer for Iodine‐125 Brachytherapy
Abstract Iodine‐125 (125I) brachytherapy, a promising form of radiotherapy, is increasingly applied in the clinical treatment of a wide range of solid tumors. However, the extremely hypoxic microenvironment in solid tumors can cause hypoxia‐induced radioresistance to 125I brachytherapy, resulting in...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-04-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202002567 |
| _version_ | 1818672923574009856 |
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| author | Sheng Peng Ruyuan Song Qingguang Lin Yanling Zhang Yuanzhong Yang Ma Luo Zhihui Zhong Xiaonan Xu Ligong Lu Shuhuai Yao Fujun Zhang |
| author_facet | Sheng Peng Ruyuan Song Qingguang Lin Yanling Zhang Yuanzhong Yang Ma Luo Zhihui Zhong Xiaonan Xu Ligong Lu Shuhuai Yao Fujun Zhang |
| author_sort | Sheng Peng |
| collection | DOAJ |
| description | Abstract Iodine‐125 (125I) brachytherapy, a promising form of radiotherapy, is increasingly applied in the clinical treatment of a wide range of solid tumors. However, the extremely hypoxic microenvironment in solid tumors can cause hypoxia‐induced radioresistance to 125I brachytherapy, resulting in therapeutic inefficacy. In this study, the aim is to sensitize hypoxic areas in solid tumors using ultrasound‐activated oxygen microbubbles for 125I brachytherapy. A modified emulsion freeze‐drying method is developed to prepare microbubbles that can be lyophilized for storage and easily reconstituted in situ before administration. The filling gas of the microbubbles is modified by the addition of sulfur hexafluoride to oxygen such that the obtained O2/SF6 microbubbles (OS MBs) achieve a much longer half‐life (>3×) than that of oxygen microbubbles. The OS MBs are tested in nasopharyngeal carcinoma (CNE2) tumor‐bearing mice and oxygen delivery by the OS MBs induced by ultrasound irradiation relieve hypoxia instantly. The post‐treatment results of brachytherapy combined with the ultrasound‐triggered OS MBs show a greatly improved therapeutic efficacy compared with brachytherapy alone, illustrating ultrasound‐mediated oxygen delivery with the developed OS MBs as a promising strategy to improve the therapeutic outcome of 125I brachytherapy in hypoxic tumors. |
| first_indexed | 2024-12-17T07:47:37Z |
| format | Article |
| id | doaj.art-875e6f8ffda345d4bcbb3a469b3c3dc5 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-12-17T07:47:37Z |
| publishDate | 2021-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-875e6f8ffda345d4bcbb3a469b3c3dc52022-12-21T21:57:57ZengWileyAdvanced Science2198-38442021-04-0187n/an/a10.1002/advs.202002567A Robust Oxygen Microbubble Radiosensitizer for Iodine‐125 BrachytherapySheng Peng0Ruyuan Song1Qingguang Lin2Yanling Zhang3Yuanzhong Yang4Ma Luo5Zhihui Zhong6Xiaonan Xu7Ligong Lu8Shuhuai Yao9Fujun Zhang10Department of Ultrasound Sun Yat‐sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 P. R. ChinaBioengineering Graduate Program Department of Chemical and Biological Engineering The Hong Kong University of Science and Technology Hong Kong 999077 P. R. ChinaDepartment of Ultrasound Sun Yat‐sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 P. R. ChinaDepartment of Imaging and Interventional Radiology Sun Yat‐sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 P. R. ChinaDepartment of Pathology Sun Yat‐sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 P. R. ChinaDepartment of Imaging and Interventional Radiology Sun Yat‐sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 P. R. ChinaDepartment of Imaging and Interventional Radiology Sun Yat‐sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 P. R. ChinaDepartment of Mechanical and Aerospace Engineering The Hong Kong University of Science and Technology Hong Kong 999077 P. R. ChinaZhuhai Interventional Medical Center Zhuhai Precision Medical Center Zhuhai People's Hospital Zhuhai Hospital of Jinan University Zhuhai 519000 P. R. ChinaBioengineering Graduate Program Department of Chemical and Biological Engineering The Hong Kong University of Science and Technology Hong Kong 999077 P. R. ChinaDepartment of Imaging and Interventional Radiology Sun Yat‐sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 P. R. ChinaAbstract Iodine‐125 (125I) brachytherapy, a promising form of radiotherapy, is increasingly applied in the clinical treatment of a wide range of solid tumors. However, the extremely hypoxic microenvironment in solid tumors can cause hypoxia‐induced radioresistance to 125I brachytherapy, resulting in therapeutic inefficacy. In this study, the aim is to sensitize hypoxic areas in solid tumors using ultrasound‐activated oxygen microbubbles for 125I brachytherapy. A modified emulsion freeze‐drying method is developed to prepare microbubbles that can be lyophilized for storage and easily reconstituted in situ before administration. The filling gas of the microbubbles is modified by the addition of sulfur hexafluoride to oxygen such that the obtained O2/SF6 microbubbles (OS MBs) achieve a much longer half‐life (>3×) than that of oxygen microbubbles. The OS MBs are tested in nasopharyngeal carcinoma (CNE2) tumor‐bearing mice and oxygen delivery by the OS MBs induced by ultrasound irradiation relieve hypoxia instantly. The post‐treatment results of brachytherapy combined with the ultrasound‐triggered OS MBs show a greatly improved therapeutic efficacy compared with brachytherapy alone, illustrating ultrasound‐mediated oxygen delivery with the developed OS MBs as a promising strategy to improve the therapeutic outcome of 125I brachytherapy in hypoxic tumors.https://doi.org/10.1002/advs.202002567brachytherapyiodine‐125oxygen microbubblestumor hypoxiaultrasound |
| spellingShingle | Sheng Peng Ruyuan Song Qingguang Lin Yanling Zhang Yuanzhong Yang Ma Luo Zhihui Zhong Xiaonan Xu Ligong Lu Shuhuai Yao Fujun Zhang A Robust Oxygen Microbubble Radiosensitizer for Iodine‐125 Brachytherapy Advanced Science brachytherapy iodine‐125 oxygen microbubbles tumor hypoxia ultrasound |
| title | A Robust Oxygen Microbubble Radiosensitizer for Iodine‐125 Brachytherapy |
| title_full | A Robust Oxygen Microbubble Radiosensitizer for Iodine‐125 Brachytherapy |
| title_fullStr | A Robust Oxygen Microbubble Radiosensitizer for Iodine‐125 Brachytherapy |
| title_full_unstemmed | A Robust Oxygen Microbubble Radiosensitizer for Iodine‐125 Brachytherapy |
| title_short | A Robust Oxygen Microbubble Radiosensitizer for Iodine‐125 Brachytherapy |
| title_sort | robust oxygen microbubble radiosensitizer for iodine 125 brachytherapy |
| topic | brachytherapy iodine‐125 oxygen microbubbles tumor hypoxia ultrasound |
| url | https://doi.org/10.1002/advs.202002567 |
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