Positive Allosteric Modulators of SERCA Pump Restore Dendritic Spines and Rescue Long-Term Potentiation Defects in Alzheimer’s Disease Mouse Model

Positive Allosteric Modulators of SERCA Pump Restore Dendritic Spines and Rescue Long-Term Potentiation Defects in Alzheimer’s Disease Mouse Model

Alzheimer’s disease (AD) is a neurodegenerative disorder that affects memory formation and storage processes. Dysregulated neuronal calcium (Ca<sup>2+</sup>) has been identified as one of the key pathogenic events in AD, and it has been suggested that pharmacological agents that stabiliz...

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Bibliographic Details
Main Authors: Anastasiya Rakovskaya, Alexander Erofeev, Egor Vinokurov, Ekaterina Pchitskaya, Russell Dahl, Ilya Bezprozvanny
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:International Journal of Molecular Sciences
Subjects:
SERCA
positive allosteric modulators
calcium
Alzheimer’s disease
beta-amyloid
dendritic spines
Online Access:https://www.mdpi.com/1422-0067/24/18/13973

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