Factors Affecting the Analytical Performance of Magnetic Molecularly Imprinted Polymers
During the last few years, separation techniques using molecular imprinting polymers (MIPs) have been developed, making certain improvements using magnetic properties. Compared to MIP, Magnetic molecularly imprinted polymers (MMIPs) have high selectivity in sample pre-treatment and allow for fast an...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-07-01
|
| Series: | Polymers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4360/14/15/3008 |
| _version_ | 1797412578810396672 |
|---|---|
| author | Nur Masyithah Zamruddin Herman Herman Laode Rijai Aliya Nur Hasanah |
| author_facet | Nur Masyithah Zamruddin Herman Herman Laode Rijai Aliya Nur Hasanah |
| author_sort | Nur Masyithah Zamruddin |
| collection | DOAJ |
| description | During the last few years, separation techniques using molecular imprinting polymers (MIPs) have been developed, making certain improvements using magnetic properties. Compared to MIP, Magnetic molecularly imprinted polymers (MMIPs) have high selectivity in sample pre-treatment and allow for fast and easy isolation of the target analyte. Its magnetic properties and good extraction performance depend on the MMIP synthesis step, which consists of 4 steps, namely magnetite manufacture, magnetic coating using modified components, polymerization and template desorption. This review discusses the factors that will affect the performance of MMIP as a selective sorbent at each stage. MMIP, using Fe<sub>3</sub>O<sub>4</sub> as a magnetite core, showed strong superparamagnetism; it was prepared using the co-precipitation method using FeCl<sub>3</sub>·6H<sub>2</sub>O and FeCl<sub>2</sub>·H<sub>2</sub>O to obtain high magnetic properties, using NH<sub>4</sub>OH solution added for higher crystallinity. In magnetite synthesis, the use of a higher temperature and reaction time will result in a larger nanoparticle size and high magnetization saturation, while a higher pH value will result in a smaller particle size. In the modification step, the use of high amounts of oleic acid results in smaller nanoparticles; furthermore, determining the correct molar ratio between FeCl<sub>3</sub> and the shielding agent will also result in smaller particles. The next factor is that the proper ratio of functional monomer, cross-linker and solvent will improve printing efficiency. Thus, it will produce MMIP with high selectivity in sample pre-treatment. |
| first_indexed | 2024-03-09T05:05:11Z |
| format | Article |
| id | doaj.art-87603fa32a0c4447a9d24f14662be607 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T05:05:11Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-87603fa32a0c4447a9d24f14662be6072023-12-03T12:56:02ZengMDPI AGPolymers2073-43602022-07-011415300810.3390/polym14153008Factors Affecting the Analytical Performance of Magnetic Molecularly Imprinted PolymersNur Masyithah Zamruddin0Herman Herman1Laode Rijai2Aliya Nur Hasanah3Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Padjadjaran University, Jl. Raya Bandung Sumedang KM 21, Sumedang 45363, IndonesiaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Mulawarman University, Gunung Kelua 75119, IndonesiaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Mulawarman University, Gunung Kelua 75119, IndonesiaDepartment of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Padjadjaran University, Jl. Raya Bandung Sumedang KM 21, Sumedang 45363, IndonesiaDuring the last few years, separation techniques using molecular imprinting polymers (MIPs) have been developed, making certain improvements using magnetic properties. Compared to MIP, Magnetic molecularly imprinted polymers (MMIPs) have high selectivity in sample pre-treatment and allow for fast and easy isolation of the target analyte. Its magnetic properties and good extraction performance depend on the MMIP synthesis step, which consists of 4 steps, namely magnetite manufacture, magnetic coating using modified components, polymerization and template desorption. This review discusses the factors that will affect the performance of MMIP as a selective sorbent at each stage. MMIP, using Fe<sub>3</sub>O<sub>4</sub> as a magnetite core, showed strong superparamagnetism; it was prepared using the co-precipitation method using FeCl<sub>3</sub>·6H<sub>2</sub>O and FeCl<sub>2</sub>·H<sub>2</sub>O to obtain high magnetic properties, using NH<sub>4</sub>OH solution added for higher crystallinity. In magnetite synthesis, the use of a higher temperature and reaction time will result in a larger nanoparticle size and high magnetization saturation, while a higher pH value will result in a smaller particle size. In the modification step, the use of high amounts of oleic acid results in smaller nanoparticles; furthermore, determining the correct molar ratio between FeCl<sub>3</sub> and the shielding agent will also result in smaller particles. The next factor is that the proper ratio of functional monomer, cross-linker and solvent will improve printing efficiency. Thus, it will produce MMIP with high selectivity in sample pre-treatment.https://www.mdpi.com/2073-4360/14/15/3008magnetic molecularly imprinted polymer (MMIP)factors affecting MMIPcomponents of MMIPmagnetic separation technology |
| spellingShingle | Nur Masyithah Zamruddin Herman Herman Laode Rijai Aliya Nur Hasanah Factors Affecting the Analytical Performance of Magnetic Molecularly Imprinted Polymers Polymers magnetic molecularly imprinted polymer (MMIP) factors affecting MMIP components of MMIP magnetic separation technology |
| title | Factors Affecting the Analytical Performance of Magnetic Molecularly Imprinted Polymers |
| title_full | Factors Affecting the Analytical Performance of Magnetic Molecularly Imprinted Polymers |
| title_fullStr | Factors Affecting the Analytical Performance of Magnetic Molecularly Imprinted Polymers |
| title_full_unstemmed | Factors Affecting the Analytical Performance of Magnetic Molecularly Imprinted Polymers |
| title_short | Factors Affecting the Analytical Performance of Magnetic Molecularly Imprinted Polymers |
| title_sort | factors affecting the analytical performance of magnetic molecularly imprinted polymers |
| topic | magnetic molecularly imprinted polymer (MMIP) factors affecting MMIP components of MMIP magnetic separation technology |
| url | https://www.mdpi.com/2073-4360/14/15/3008 |
| work_keys_str_mv | AT nurmasyithahzamruddin factorsaffectingtheanalyticalperformanceofmagneticmolecularlyimprintedpolymers AT hermanherman factorsaffectingtheanalyticalperformanceofmagneticmolecularlyimprintedpolymers AT laoderijai factorsaffectingtheanalyticalperformanceofmagneticmolecularlyimprintedpolymers AT aliyanurhasanah factorsaffectingtheanalyticalperformanceofmagneticmolecularlyimprintedpolymers |