Variation of Anti-inflammatory Cytokines in Relationship with Menopause
Aim. The aim of this study was to assess serum levels of the key anti-inflammatory cytokines in women of reproductive age and in pre and postmenopausal women. Material and Method. 175 women were enrolled and were divided into 5 groups (1 – Fertile women; 2 – Pre- and perimenopausal women; 3 – Postme...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca
2013-06-01
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| Series: | Applied Medical Informatics |
| Subjects: | |
| Online Access: | http://ami.info.umfcluj.ro/index.php/AMI/article/view/412/pdf |
| _version_ | 1818042445431046144 |
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| author | Dan MIHU Razvan CIORTEA Nicolae COSTIN Andrei Mihai MALUTAN |
| author_facet | Dan MIHU Razvan CIORTEA Nicolae COSTIN Andrei Mihai MALUTAN |
| author_sort | Dan MIHU |
| collection | DOAJ |
| description | Aim. The aim of this study was to assess serum levels of the key anti-inflammatory cytokines in women of reproductive age and in pre and postmenopausal women. Material and Method. 175 women were enrolled and were divided into 5 groups (1 – Fertile women; 2 – Pre- and perimenopausal women; 3 – Postmenopausal women; 4 – Surgically-induced menopause; 5 – Chronic inflammation). Multiplex cytokine kits were used to evaluate serum levels of interleukin-4, -10 and -13. We determined the serum levels of follicle stimulating hormone, of luteinizing hormone, 17β-estradiol, progesterone, dehydroepiandrosterone and dehydroepiandrosterone sulfate using sandwich ELISA. Results. IL-4, IL-10 and IL-17 present a statistically significant decrease (p=0.00, p=0.00, respectively p=0.0053) in women with natural or surgically induced menopause (groups 3 and 4), compared with fertile women and premenopausal women (Groups 1, 2 and 5). Serum levels of IL-4 and IL-10 are significantly higher in fertile patients with associated chronic inflammatory diseases (133.5±1.314 pg/ml, respectively 6.406±13.47 pg/ml) than in fertile patients without chronic inflammatory diseases or premenopausal women (84.67±1.22 pg/ml, respectively 0.627±0.714). Conclusions. IL-4 and IL-10, together with IL-17, show significantly lower serum values in patients with natural or surgically induced menopause compared with patients of childbearing age or in premenopause. IL-4 and IL-10 show significantly higher serum values for patients of childbearing age presenting chronic inflammatory pathology compared with patients of childbearing age without chronic inflammatory pathology or premenopausal patients. |
| first_indexed | 2024-12-10T08:46:26Z |
| format | Article |
| id | doaj.art-8765172f901e4bf19c2230649e5ab619 |
| institution | Directory Open Access Journal |
| issn | 1224-5593 2067-7855 |
| language | English |
| last_indexed | 2024-12-10T08:46:26Z |
| publishDate | 2013-06-01 |
| publisher | Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca |
| record_format | Article |
| series | Applied Medical Informatics |
| spelling | doaj.art-8765172f901e4bf19c2230649e5ab6192022-12-22T01:55:43ZengIuliu Hatieganu University of Medicine and Pharmacy, Cluj-NapocaApplied Medical Informatics1224-55932067-78552013-06-013223038Variation of Anti-inflammatory Cytokines in Relationship with MenopauseDan MIHURazvan CIORTEANicolae COSTINAndrei Mihai MALUTANAim. The aim of this study was to assess serum levels of the key anti-inflammatory cytokines in women of reproductive age and in pre and postmenopausal women. Material and Method. 175 women were enrolled and were divided into 5 groups (1 – Fertile women; 2 – Pre- and perimenopausal women; 3 – Postmenopausal women; 4 – Surgically-induced menopause; 5 – Chronic inflammation). Multiplex cytokine kits were used to evaluate serum levels of interleukin-4, -10 and -13. We determined the serum levels of follicle stimulating hormone, of luteinizing hormone, 17β-estradiol, progesterone, dehydroepiandrosterone and dehydroepiandrosterone sulfate using sandwich ELISA. Results. IL-4, IL-10 and IL-17 present a statistically significant decrease (p=0.00, p=0.00, respectively p=0.0053) in women with natural or surgically induced menopause (groups 3 and 4), compared with fertile women and premenopausal women (Groups 1, 2 and 5). Serum levels of IL-4 and IL-10 are significantly higher in fertile patients with associated chronic inflammatory diseases (133.5±1.314 pg/ml, respectively 6.406±13.47 pg/ml) than in fertile patients without chronic inflammatory diseases or premenopausal women (84.67±1.22 pg/ml, respectively 0.627±0.714). Conclusions. IL-4 and IL-10, together with IL-17, show significantly lower serum values in patients with natural or surgically induced menopause compared with patients of childbearing age or in premenopause. IL-4 and IL-10 show significantly higher serum values for patients of childbearing age presenting chronic inflammatory pathology compared with patients of childbearing age without chronic inflammatory pathology or premenopausal patients.http://ami.info.umfcluj.ro/index.php/AMI/article/view/412/pdfmenopausecytokineinterleukinsteroid hormones |
| spellingShingle | Dan MIHU Razvan CIORTEA Nicolae COSTIN Andrei Mihai MALUTAN Variation of Anti-inflammatory Cytokines in Relationship with Menopause Applied Medical Informatics menopause cytokine interleukin steroid hormones |
| title | Variation of Anti-inflammatory Cytokines in Relationship with Menopause |
| title_full | Variation of Anti-inflammatory Cytokines in Relationship with Menopause |
| title_fullStr | Variation of Anti-inflammatory Cytokines in Relationship with Menopause |
| title_full_unstemmed | Variation of Anti-inflammatory Cytokines in Relationship with Menopause |
| title_short | Variation of Anti-inflammatory Cytokines in Relationship with Menopause |
| title_sort | variation of anti inflammatory cytokines in relationship with menopause |
| topic | menopause cytokine interleukin steroid hormones |
| url | http://ami.info.umfcluj.ro/index.php/AMI/article/view/412/pdf |
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