Sick sinus syndrome: decompensation prevention

In 83 patients with sick sinus syndrome and without severe impairment of central/systemic hemodynamics (compensated SSS), decompensation prevention by long-tem atenolol therapy was investigated. Follow-up lasted for 6-24 months, mean atenolol dose was 26,2+3,5 mg/d. In patients with initially decrea...

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Main Authors: V. M. Provotorov, Z. S. Shatilova, M. L. Glukhovsky
Format: Article
Language:Russian
Published: «FIRMA «SILICEA» LLC 2004-12-01
Series:Российский кардиологический журнал
Subjects:
Online Access:https://russjcardiol.elpub.ru/jour/article/view/2330
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author V. M. Provotorov
Z. S. Shatilova
M. L. Glukhovsky
author_facet V. M. Provotorov
Z. S. Shatilova
M. L. Glukhovsky
author_sort V. M. Provotorov
collection DOAJ
description In 83 patients with sick sinus syndrome and without severe impairment of central/systemic hemodynamics (compensated SSS), decompensation prevention by long-tem atenolol therapy was investigated. Follow-up lasted for 6-24 months, mean atenolol dose was 26,2+3,5 mg/d. In patients with initially decreased heart rate (HR) during pharmaceutical autonomous blockade (PAB) test, treatment was associated with substantial decline in congestive heart failure and chronic atrial fibrillation incidence. Atenolol intolerance was predicted by prolonged sinus node recovery time in baseline PAB test (by 280 sec or more). No significant influence on syncope or pacemaker implantation incidence was observed.
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spelling doaj.art-8765634613b74aa68601c2cc943eb7172023-03-29T21:23:11Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202004-12-010674772076Sick sinus syndrome: decompensation preventionV. M. Provotorov0Z. S. Shatilova1M. L. Glukhovsky2Воронежская государственная медицинская академия имени Н.Н.БурденкоВоронежская государственная медицинская академия имени Н.Н.БурденкоВоронежская государственная медицинская академия имени Н.Н.БурденкоIn 83 patients with sick sinus syndrome and without severe impairment of central/systemic hemodynamics (compensated SSS), decompensation prevention by long-tem atenolol therapy was investigated. Follow-up lasted for 6-24 months, mean atenolol dose was 26,2+3,5 mg/d. In patients with initially decreased heart rate (HR) during pharmaceutical autonomous blockade (PAB) test, treatment was associated with substantial decline in congestive heart failure and chronic atrial fibrillation incidence. Atenolol intolerance was predicted by prolonged sinus node recovery time in baseline PAB test (by 280 sec or more). No significant influence on syncope or pacemaker implantation incidence was observed.https://russjcardiol.elpub.ru/jour/article/view/2330sick sinus syndromecompensationatenololheart failure
spellingShingle V. M. Provotorov
Z. S. Shatilova
M. L. Glukhovsky
Sick sinus syndrome: decompensation prevention
Российский кардиологический журнал
sick sinus syndrome
compensation
atenolol
heart failure
title Sick sinus syndrome: decompensation prevention
title_full Sick sinus syndrome: decompensation prevention
title_fullStr Sick sinus syndrome: decompensation prevention
title_full_unstemmed Sick sinus syndrome: decompensation prevention
title_short Sick sinus syndrome: decompensation prevention
title_sort sick sinus syndrome decompensation prevention
topic sick sinus syndrome
compensation
atenolol
heart failure
url https://russjcardiol.elpub.ru/jour/article/view/2330
work_keys_str_mv AT vmprovotorov sicksinussyndromedecompensationprevention
AT zsshatilova sicksinussyndromedecompensationprevention
AT mlglukhovsky sicksinussyndromedecompensationprevention