COVID-19 vaccine short-term adverse events in the real-life family practice in Krakow, Poland
AbstractBackground In manufacturers’ trials, vaccination against COVID-19 proved to be safe and effective. The officially reported frequency of vaccine adverse events (VAEs) in Poland is lower than that declared by the manufacturers. The anti-vaccination activists questioned the trustworthiness of o...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | European Journal of General Practice |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/13814788.2022.2147500 |
| _version_ | 1797809659247067136 |
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| author | Marek Oleszczyk Zuzanna Marciniak Katarzyna Nessler Ewa Wójtowicz Nataliya Szozda Elżbieta Kryj-Radziszewska Maria Boroń Klaudia Gajos Mateusz P. Paziewski Paweł Sajdak Adam Windak |
| author_facet | Marek Oleszczyk Zuzanna Marciniak Katarzyna Nessler Ewa Wójtowicz Nataliya Szozda Elżbieta Kryj-Radziszewska Maria Boroń Klaudia Gajos Mateusz P. Paziewski Paweł Sajdak Adam Windak |
| author_sort | Marek Oleszczyk |
| collection | DOAJ |
| description | AbstractBackground In manufacturers’ trials, vaccination against COVID-19 proved to be safe and effective. The officially reported frequency of vaccine adverse events (VAEs) in Poland is lower than that declared by the manufacturers. The anti-vaccination activists questioned the trustworthiness of official data.Objectives The aim was to explore the real-life prevalence of VAEs in general practice settings and the factors that may influence it.Methods In this pragmatic, mixed prospective and retrospective study, patients vaccinated against COVID-19 between May and October 2021 in three GP practices in Krakow, Poland, were enrolled. Their demographic (age, sex, level of education) and clinical data (weight and height, smoking status, history of allergies, COVID-19 and chronic diseases) were collected. Then, they were interviewed about VAEs they experienced.Results Out of 1530 patients invited to participate, 1051 (69%) agreed and were eligible for analyses. Only 8.8% did not report any VAE. Pain at the injection site was the most frequently reported reaction (800, 76.2%). The most prevalent systemic ones were excessive fatigue/lethargy (527, 50.6%), sleep/circadian rhythm disturbances (433, 41.6%) and headache (399, 38.3%). Fifty required medical assistance − 39 experienced presyncope (3.7%) and 11 loss of consciousness (1.1%). Only two others were hospitalised. Females, younger adults, those with higher education and with a history of COVID-19 reported systemic VAEs more frequently, while those who were older and obese were less likely to report local reactions.Conclusion Although more than 90% of patients vaccinated against COVID-19 in general practice settings may experience VAEs, in short-term observation, the vast majority are localised and mild. |
| first_indexed | 2024-03-13T06:55:59Z |
| format | Article |
| id | doaj.art-8765cea31bbe4ba7bdc5eb8ce627f0dd |
| institution | Directory Open Access Journal |
| issn | 1381-4788 1751-1402 |
| language | English |
| last_indexed | 2024-03-13T06:55:59Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | European Journal of General Practice |
| spelling | doaj.art-8765cea31bbe4ba7bdc5eb8ce627f0dd2023-06-07T08:32:33ZengTaylor & Francis GroupEuropean Journal of General Practice1381-47881751-14022023-12-0129210.1080/13814788.2022.2147500COVID-19 vaccine short-term adverse events in the real-life family practice in Krakow, PolandMarek Oleszczyk0Zuzanna Marciniak1Katarzyna Nessler2Ewa Wójtowicz3Nataliya Szozda4Elżbieta Kryj-Radziszewska5Maria Boroń6Klaudia Gajos7Mateusz P. Paziewski8Paweł Sajdak9Adam Windak10Department of Family Medicine, Jagiellonian University Medical College, Krakow, PolandFamily Medicine Student Interest Group, Faculty of Medicine, Jagiellonian University Medical College, Krakow, PolandDepartment of Family Medicine, Jagiellonian University Medical College, Krakow, PolandDepartment of Family Medicine, Jagiellonian University Medical College, Krakow, PolandDepartment of Family Medicine, Jagiellonian University Medical College, Krakow, PolandDepartment of Family Medicine, Jagiellonian University Medical College, Krakow, PolandFamily Medicine Student Interest Group, Faculty of Medicine, Jagiellonian University Medical College, Krakow, PolandFamily Medicine Student Interest Group, Faculty of Medicine, Jagiellonian University Medical College, Krakow, PolandFamily Medicine Student Interest Group, Faculty of Medicine, Jagiellonian University Medical College, Krakow, PolandFamily Medicine Student Interest Group, Faculty of Medicine, Jagiellonian University Medical College, Krakow, PolandDepartment of Family Medicine, Jagiellonian University Medical College, Krakow, PolandAbstractBackground In manufacturers’ trials, vaccination against COVID-19 proved to be safe and effective. The officially reported frequency of vaccine adverse events (VAEs) in Poland is lower than that declared by the manufacturers. The anti-vaccination activists questioned the trustworthiness of official data.Objectives The aim was to explore the real-life prevalence of VAEs in general practice settings and the factors that may influence it.Methods In this pragmatic, mixed prospective and retrospective study, patients vaccinated against COVID-19 between May and October 2021 in three GP practices in Krakow, Poland, were enrolled. Their demographic (age, sex, level of education) and clinical data (weight and height, smoking status, history of allergies, COVID-19 and chronic diseases) were collected. Then, they were interviewed about VAEs they experienced.Results Out of 1530 patients invited to participate, 1051 (69%) agreed and were eligible for analyses. Only 8.8% did not report any VAE. Pain at the injection site was the most frequently reported reaction (800, 76.2%). The most prevalent systemic ones were excessive fatigue/lethargy (527, 50.6%), sleep/circadian rhythm disturbances (433, 41.6%) and headache (399, 38.3%). Fifty required medical assistance − 39 experienced presyncope (3.7%) and 11 loss of consciousness (1.1%). Only two others were hospitalised. Females, younger adults, those with higher education and with a history of COVID-19 reported systemic VAEs more frequently, while those who were older and obese were less likely to report local reactions.Conclusion Although more than 90% of patients vaccinated against COVID-19 in general practice settings may experience VAEs, in short-term observation, the vast majority are localised and mild.https://www.tandfonline.com/doi/10.1080/13814788.2022.2147500COVID-19 vaccinevaccine adverse eventprimary carefamily medicinepragmatic study |
| spellingShingle | Marek Oleszczyk Zuzanna Marciniak Katarzyna Nessler Ewa Wójtowicz Nataliya Szozda Elżbieta Kryj-Radziszewska Maria Boroń Klaudia Gajos Mateusz P. Paziewski Paweł Sajdak Adam Windak COVID-19 vaccine short-term adverse events in the real-life family practice in Krakow, Poland European Journal of General Practice COVID-19 vaccine vaccine adverse event primary care family medicine pragmatic study |
| title | COVID-19 vaccine short-term adverse events in the real-life family practice in Krakow, Poland |
| title_full | COVID-19 vaccine short-term adverse events in the real-life family practice in Krakow, Poland |
| title_fullStr | COVID-19 vaccine short-term adverse events in the real-life family practice in Krakow, Poland |
| title_full_unstemmed | COVID-19 vaccine short-term adverse events in the real-life family practice in Krakow, Poland |
| title_short | COVID-19 vaccine short-term adverse events in the real-life family practice in Krakow, Poland |
| title_sort | covid 19 vaccine short term adverse events in the real life family practice in krakow poland |
| topic | COVID-19 vaccine vaccine adverse event primary care family medicine pragmatic study |
| url | https://www.tandfonline.com/doi/10.1080/13814788.2022.2147500 |
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