P-75 UPDATE OF CLINICO-EPIDEMIOLOGICAL CHARACTERISTICS OF PRIMARY BILIAR CHOLANGITIS IN URUGUAY
Introduction: Primary biliary cholangitis (PBC) is an autoimmune cholestatic liver disease of increasing prevalence, female-predominant, and usually diagnosed in the fifth decade of life. Objective: To update the description of clinico-epidemiological characteristics of a series of Uruguayan patient...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-09-01
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| Series: | Annals of Hepatology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S166526812100137X |
| _version_ | 1818650320046129152 |
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| author | Etchandy Patricia Chiodi Daniela Veloso Victoria Hernandez Nelia |
| author_facet | Etchandy Patricia Chiodi Daniela Veloso Victoria Hernandez Nelia |
| author_sort | Etchandy Patricia |
| collection | DOAJ |
| description | Introduction: Primary biliary cholangitis (PBC) is an autoimmune cholestatic liver disease of increasing prevalence, female-predominant, and usually diagnosed in the fifth decade of life. Objective: To update the description of clinico-epidemiological characteristics of a series of Uruguayan patients diagnosed with PBC. Methods: Descriptive, multi-centric study including Uruguayan patients diagnosed with PBC (at least two of the following criteria: biochemical cholestasis, autoantibodies —AMA, antinuclear with anticentromere, sp100, or gp210 patterns— and compatible liver biopsy). Age, sex, symptoms, associated diseases, laboratory, imaging, histological and elastography parameters were recorded in the diagnosis. Results: One hundred twenty-nine patients (81 belonging to the first report), 93% female, with an average age of 57 years old (23 - 81) were included. Sixty-nine percent had at least one symptom and 59% had pruritus. Eighty-three percent were AMA-positive and in 41% of patients one or more associated diseases were confirmed. (Table). Histological studies were available in 40 patients (31%), 26 (65%) of which had advanced liver fibrosis or cirrhosis. Elastography was available in 6 patients, 2 of which (33%) were diagnosed with cirrhosis. Six patients (5%) were diagnosed with cirrhosis due to presence of ascites. The global survival rate was 84%. Survival depending on the presence or absence of symptoms was 251 months (95% CI, 229 - 274) and 241 months (95% CI, 238 - 275) respectively (p>0.05). Median survival for cirrhotic patients was 201 months (CI 95%, 160 – 242) versus 191 (CI 95%, 172 – 210) for non-cirrhotics (p>0.05). Conclusions: As previously reported, female prevalence and frequent association with other diseases –mainly autoimmune– remain. The presence of symptoms or cirrhosis showed no association with survival. |
| first_indexed | 2024-12-17T01:48:20Z |
| format | Article |
| id | doaj.art-8765d1351a61460fa3b876d622e3dafd |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-12-17T01:48:20Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-8765d1351a61460fa3b876d622e3dafd2022-12-21T22:08:08ZengElsevierAnnals of Hepatology1665-26812021-09-0124100438P-75 UPDATE OF CLINICO-EPIDEMIOLOGICAL CHARACTERISTICS OF PRIMARY BILIAR CHOLANGITIS IN URUGUAYEtchandy Patricia0Chiodi Daniela1Veloso Victoria2Hernandez Nelia3Clínica de Gastroenterología, Hospital de Clínicas, Facultad de Medicina, UDELAR, MontevideoClínica de Gastroenterología, Hospital de Clínicas, Facultad de Medicina, UDELAR, MontevideoServicio de Gastroenterología, Asociación Española, Montevideo, UruguayClínica de Gastroenterología, Hospital de Clínicas, Facultad de Medicina, UDELAR, MontevideoIntroduction: Primary biliary cholangitis (PBC) is an autoimmune cholestatic liver disease of increasing prevalence, female-predominant, and usually diagnosed in the fifth decade of life. Objective: To update the description of clinico-epidemiological characteristics of a series of Uruguayan patients diagnosed with PBC. Methods: Descriptive, multi-centric study including Uruguayan patients diagnosed with PBC (at least two of the following criteria: biochemical cholestasis, autoantibodies —AMA, antinuclear with anticentromere, sp100, or gp210 patterns— and compatible liver biopsy). Age, sex, symptoms, associated diseases, laboratory, imaging, histological and elastography parameters were recorded in the diagnosis. Results: One hundred twenty-nine patients (81 belonging to the first report), 93% female, with an average age of 57 years old (23 - 81) were included. Sixty-nine percent had at least one symptom and 59% had pruritus. Eighty-three percent were AMA-positive and in 41% of patients one or more associated diseases were confirmed. (Table). Histological studies were available in 40 patients (31%), 26 (65%) of which had advanced liver fibrosis or cirrhosis. Elastography was available in 6 patients, 2 of which (33%) were diagnosed with cirrhosis. Six patients (5%) were diagnosed with cirrhosis due to presence of ascites. The global survival rate was 84%. Survival depending on the presence or absence of symptoms was 251 months (95% CI, 229 - 274) and 241 months (95% CI, 238 - 275) respectively (p>0.05). Median survival for cirrhotic patients was 201 months (CI 95%, 160 – 242) versus 191 (CI 95%, 172 – 210) for non-cirrhotics (p>0.05). Conclusions: As previously reported, female prevalence and frequent association with other diseases –mainly autoimmune– remain. The presence of symptoms or cirrhosis showed no association with survival.http://www.sciencedirect.com/science/article/pii/S166526812100137X |
| spellingShingle | Etchandy Patricia Chiodi Daniela Veloso Victoria Hernandez Nelia P-75 UPDATE OF CLINICO-EPIDEMIOLOGICAL CHARACTERISTICS OF PRIMARY BILIAR CHOLANGITIS IN URUGUAY Annals of Hepatology |
| title | P-75 UPDATE OF CLINICO-EPIDEMIOLOGICAL CHARACTERISTICS OF PRIMARY BILIAR CHOLANGITIS IN URUGUAY |
| title_full | P-75 UPDATE OF CLINICO-EPIDEMIOLOGICAL CHARACTERISTICS OF PRIMARY BILIAR CHOLANGITIS IN URUGUAY |
| title_fullStr | P-75 UPDATE OF CLINICO-EPIDEMIOLOGICAL CHARACTERISTICS OF PRIMARY BILIAR CHOLANGITIS IN URUGUAY |
| title_full_unstemmed | P-75 UPDATE OF CLINICO-EPIDEMIOLOGICAL CHARACTERISTICS OF PRIMARY BILIAR CHOLANGITIS IN URUGUAY |
| title_short | P-75 UPDATE OF CLINICO-EPIDEMIOLOGICAL CHARACTERISTICS OF PRIMARY BILIAR CHOLANGITIS IN URUGUAY |
| title_sort | p 75 update of clinico epidemiological characteristics of primary biliar cholangitis in uruguay |
| url | http://www.sciencedirect.com/science/article/pii/S166526812100137X |
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