Expression of expanded GGC repeats within NOTCH2NLC causes cardiac dysfunction in mouse models

Expression of expanded GGC repeats within NOTCH2NLC causes cardiac dysfunction in mouse models

Abstract Background Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder characterized by widespread intranuclear inclusions in the nervous system as well as multiple visceral organs. In 2019, expanded GGC repeats within the 5′ untranslated region of the NOTCH2NLC gene...

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Bibliographic Details
Main Authors: Yongcheng Pan, Ying Jiang, Juan Wan, Zhengmao Hu, Hong Jiang, Lu Shen, Beisha Tang, Yun Tian, Qiong Liu
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Cell & Bioscience
Subjects:
NOTCH2NLC gene
GGC repeat expansion
NOTCH2NLC-polyG inclusions
Cardiomyocyte
Cardiac dysfunction
Mitochondria
Online Access:https://doi.org/10.1186/s13578-023-01111-6

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