Association between childhood psychiatric disorders and psychotic experiences in adolescence: A population-based longitudinal study
Background: Adolescent psychotic experiences (PEs) are common, and are associated with both psychotic and non-psychotic illnesses. In order to examine psychopathological and cognitive antecedents of adolescent PEs, we have conducted a longitudinal study of common childhood psychiatric disorders and...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-08-01
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| Series: | Comprehensive Psychiatry |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0010440X16300852 |
| _version_ | 1811286622286643200 |
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| author | Caroline Siebald Golam M. Khandaker Stanley Zammit Glyn Lewis Peter B. Jones |
| author_facet | Caroline Siebald Golam M. Khandaker Stanley Zammit Glyn Lewis Peter B. Jones |
| author_sort | Caroline Siebald |
| collection | DOAJ |
| description | Background: Adolescent psychotic experiences (PEs) are common, and are associated with both psychotic and non-psychotic illnesses. In order to examine psychopathological and cognitive antecedents of adolescent PEs, we have conducted a longitudinal study of common childhood psychiatric disorders and subsequent adolescent PEs in the population-based prospective ALSPAC birth cohort. Method: Depression, anxiety, attention deficit hyperactivity disorder, oppositional defiant or conduct disorder, and pervasive developmental disorder were diagnosed according to DSM-IV criteria in 8253 participants at age 8 years. IQ was assessed by WISC-III also at 8 years. PEs, depressive and anxiety symptoms were assessed at 13 years. Logistic regression calculated odds ratio (OR) for PEs at 13 years associated with psychiatric disorders at 8 years. Linear regression calculated mean difference in IQ between groups with and without psychiatric disorder. Mediating effects of IQ, mood and anxiety symptoms on the psychiatric disorder-PEs relationship were examined. Results: In total, 599 children were assessed to have a DSM-IV psychiatric disorder at 8 years (7.2%). These children compared with those without any psychiatric disorder performed worse on all measures of IQ; adjusted mean difference in total IQ −6.17 (95% CI, −7.86, −4.48). Childhood psychiatric disorders were associated with PEs subsequently in adolescence; adjusted OR 1.96 (95% CI, 1.47–2.68). The association between psychiatric disorder and subsequent PEs was partly mediated by, independently, IQ deficit at 8 years and depressive and anxiety symptoms at 13 years. Conclusions: The findings indicate that adolescent PEs are associated with general cognitive ability and past and present psychopathological factors. |
| first_indexed | 2024-04-13T03:03:14Z |
| format | Article |
| id | doaj.art-8767b799b196474f8787da10d1926edf |
| institution | Directory Open Access Journal |
| issn | 0010-440X |
| language | English |
| last_indexed | 2024-04-13T03:03:14Z |
| publishDate | 2016-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Comprehensive Psychiatry |
| spelling | doaj.art-8767b799b196474f8787da10d1926edf2022-12-22T03:05:20ZengElsevierComprehensive Psychiatry0010-440X2016-08-01694552Association between childhood psychiatric disorders and psychotic experiences in adolescence: A population-based longitudinal studyCaroline Siebald0Golam M. Khandaker1Stanley Zammit2Glyn Lewis3Peter B. Jones4Department of Psychiatry, University of Cambridge, UKDepartment of Psychiatry, University of Cambridge, UK; Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK; Corresponding author at: Department of Psychiatry, Box 189, Cambridge Biomedical Campus, Cambridge CB2 2QQ, UK.Centre for Mental Health, Addiction and Suicide Research, School of Social and Community Medicine, University of Bristol, UK; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, UKDivision of Psychiatry, University College London, London, UKDepartment of Psychiatry, University of Cambridge, UK; Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UKBackground: Adolescent psychotic experiences (PEs) are common, and are associated with both psychotic and non-psychotic illnesses. In order to examine psychopathological and cognitive antecedents of adolescent PEs, we have conducted a longitudinal study of common childhood psychiatric disorders and subsequent adolescent PEs in the population-based prospective ALSPAC birth cohort. Method: Depression, anxiety, attention deficit hyperactivity disorder, oppositional defiant or conduct disorder, and pervasive developmental disorder were diagnosed according to DSM-IV criteria in 8253 participants at age 8 years. IQ was assessed by WISC-III also at 8 years. PEs, depressive and anxiety symptoms were assessed at 13 years. Logistic regression calculated odds ratio (OR) for PEs at 13 years associated with psychiatric disorders at 8 years. Linear regression calculated mean difference in IQ between groups with and without psychiatric disorder. Mediating effects of IQ, mood and anxiety symptoms on the psychiatric disorder-PEs relationship were examined. Results: In total, 599 children were assessed to have a DSM-IV psychiatric disorder at 8 years (7.2%). These children compared with those without any psychiatric disorder performed worse on all measures of IQ; adjusted mean difference in total IQ −6.17 (95% CI, −7.86, −4.48). Childhood psychiatric disorders were associated with PEs subsequently in adolescence; adjusted OR 1.96 (95% CI, 1.47–2.68). The association between psychiatric disorder and subsequent PEs was partly mediated by, independently, IQ deficit at 8 years and depressive and anxiety symptoms at 13 years. Conclusions: The findings indicate that adolescent PEs are associated with general cognitive ability and past and present psychopathological factors.http://www.sciencedirect.com/science/article/pii/S0010440X16300852 |
| spellingShingle | Caroline Siebald Golam M. Khandaker Stanley Zammit Glyn Lewis Peter B. Jones Association between childhood psychiatric disorders and psychotic experiences in adolescence: A population-based longitudinal study Comprehensive Psychiatry |
| title | Association between childhood psychiatric disorders and psychotic experiences in adolescence: A population-based longitudinal study |
| title_full | Association between childhood psychiatric disorders and psychotic experiences in adolescence: A population-based longitudinal study |
| title_fullStr | Association between childhood psychiatric disorders and psychotic experiences in adolescence: A population-based longitudinal study |
| title_full_unstemmed | Association between childhood psychiatric disorders and psychotic experiences in adolescence: A population-based longitudinal study |
| title_short | Association between childhood psychiatric disorders and psychotic experiences in adolescence: A population-based longitudinal study |
| title_sort | association between childhood psychiatric disorders and psychotic experiences in adolescence a population based longitudinal study |
| url | http://www.sciencedirect.com/science/article/pii/S0010440X16300852 |
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