Cytokines: their pathogenic and therapeutic role in chronic viral hepatitis Citoquinas: papel patogénico y terapéutico de las hepatitis crónicas víricas
Cytokines make up a network of molecules involved in the regulation of immune response and organ functional homeostasis. Cytokines coordinate both physiological and pathological processes occurring in the liver during viral infection, including infection control, inflammation, regeneration, and fibr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Aran Ediciones
2009-05-01
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| Series: | Revista Espanola de Enfermedades Digestivas |
| Subjects: | |
| Online Access: | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082009000500006 |
| _version_ | 1811265324309282816 |
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| author | J. R. Larrubia S. Benito-Martínez J. Miquel-Plaza E. Sanz-de-Villalobos F. González-Mateos T. Parra |
| author_facet | J. R. Larrubia S. Benito-Martínez J. Miquel-Plaza E. Sanz-de-Villalobos F. González-Mateos T. Parra |
| author_sort | J. R. Larrubia |
| collection | DOAJ |
| description | Cytokines make up a network of molecules involved in the regulation of immune response and organ functional homeostasis. Cytokines coordinate both physiological and pathological processes occurring in the liver during viral infection, including infection control, inflammation, regeneration, and fibrosis. Hepatitis B and hepatitis C viruses interfere with the complex cytokine network brought about by the immune system and liver cells in order to prevent an effective immune response, capable of viral control. This situation leads to intrahepatic sequestration of nonspecific inflammatory infiltrates that release proinflammatory cytokines, which in turn favor chronic inflammation and fibrosis. The therapeutical administration of cytokines such as interferon alpha may result in viral clearance during persistent infection, and revert this process. |
| first_indexed | 2024-04-12T20:21:35Z |
| format | Article |
| id | doaj.art-8768060d1caf420bb24fa34a9877fe9e |
| institution | Directory Open Access Journal |
| issn | 1130-0108 |
| language | English |
| last_indexed | 2024-04-12T20:21:35Z |
| publishDate | 2009-05-01 |
| publisher | Aran Ediciones |
| record_format | Article |
| series | Revista Espanola de Enfermedades Digestivas |
| spelling | doaj.art-8768060d1caf420bb24fa34a9877fe9e2022-12-22T03:17:59ZengAran EdicionesRevista Espanola de Enfermedades Digestivas1130-01082009-05-011015343351Cytokines: their pathogenic and therapeutic role in chronic viral hepatitis Citoquinas: papel patogénico y terapéutico de las hepatitis crónicas víricasJ. R. LarrubiaS. Benito-MartínezJ. Miquel-PlazaE. Sanz-de-VillalobosF. González-MateosT. ParraCytokines make up a network of molecules involved in the regulation of immune response and organ functional homeostasis. Cytokines coordinate both physiological and pathological processes occurring in the liver during viral infection, including infection control, inflammation, regeneration, and fibrosis. Hepatitis B and hepatitis C viruses interfere with the complex cytokine network brought about by the immune system and liver cells in order to prevent an effective immune response, capable of viral control. This situation leads to intrahepatic sequestration of nonspecific inflammatory infiltrates that release proinflammatory cytokines, which in turn favor chronic inflammation and fibrosis. The therapeutical administration of cytokines such as interferon alpha may result in viral clearance during persistent infection, and revert this process.http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082009000500006CytokinesChronic hepatitisHBVHCVImmunopathogenesis |
| spellingShingle | J. R. Larrubia S. Benito-Martínez J. Miquel-Plaza E. Sanz-de-Villalobos F. González-Mateos T. Parra Cytokines: their pathogenic and therapeutic role in chronic viral hepatitis Citoquinas: papel patogénico y terapéutico de las hepatitis crónicas víricas Revista Espanola de Enfermedades Digestivas Cytokines Chronic hepatitis HBV HCV Immunopathogenesis |
| title | Cytokines: their pathogenic and therapeutic role in chronic viral hepatitis Citoquinas: papel patogénico y terapéutico de las hepatitis crónicas víricas |
| title_full | Cytokines: their pathogenic and therapeutic role in chronic viral hepatitis Citoquinas: papel patogénico y terapéutico de las hepatitis crónicas víricas |
| title_fullStr | Cytokines: their pathogenic and therapeutic role in chronic viral hepatitis Citoquinas: papel patogénico y terapéutico de las hepatitis crónicas víricas |
| title_full_unstemmed | Cytokines: their pathogenic and therapeutic role in chronic viral hepatitis Citoquinas: papel patogénico y terapéutico de las hepatitis crónicas víricas |
| title_short | Cytokines: their pathogenic and therapeutic role in chronic viral hepatitis Citoquinas: papel patogénico y terapéutico de las hepatitis crónicas víricas |
| title_sort | cytokines their pathogenic and therapeutic role in chronic viral hepatitis citoquinas papel patogenico y terapeutico de las hepatitis cronicas viricas |
| topic | Cytokines Chronic hepatitis HBV HCV Immunopathogenesis |
| url | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082009000500006 |
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