Sex Hormone-Binding Globulin Is Associated with Obesity and Dyslipidemia in Prepubertal Children
Sex hormone-binding globulin (SHBG) is associated with age, sex, and puberty. The association of SHBG with various diseases has been suggested nowadays, however, the relationships in prepubertal children have not been sufficiently investigated. This study analyzed the relationship of SHBG with body...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/7/12/272 |
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| author | Gihong Park Kyungchul Song Youngha Choi Jun Suk Oh Han Saem Choi Junghwan Suh Ahreum Kwon Ho-Seong Kim Hyun Wook Chae |
| author_facet | Gihong Park Kyungchul Song Youngha Choi Jun Suk Oh Han Saem Choi Junghwan Suh Ahreum Kwon Ho-Seong Kim Hyun Wook Chae |
| author_sort | Gihong Park |
| collection | DOAJ |
| description | Sex hormone-binding globulin (SHBG) is associated with age, sex, and puberty. The association of SHBG with various diseases has been suggested nowadays, however, the relationships in prepubertal children have not been sufficiently investigated. This study analyzed the relationship of SHBG with body mass index (BMI) and plasma lipid levels in prepubertal children. We evaluated the association of SHBG with BMI among the 693 prepubertal children subdivided into normal, overweight, and obese groups, with plasma lipid levels among the children subdivided into normal and dyslipidemia groups. The obese and overweight group had lower SHBG levels than the normal BMI group in both sexes. The dyslipidemia group included subjects with low high-density lipoprotein cholesterol (HDL-C), high triglycerides (TG), or a high atherogenic index of plasma (AIP); this group had lower SHBG than the normal lipid group. SHBG was positively correlated with HDL-C, and negatively correlated with TG and AIP. After adjusting for BMI, SHBG was positively correlated with HDL-C and negatively correlated with TG and AIP in all groups. In conclusion, SHBG levels are closely correlated with BMI in prepubertal children. SHBG may play a meaningful role in the decrease in HDL-C and increase in TG during prepubertal age. |
| first_indexed | 2024-03-10T14:19:33Z |
| format | Article |
| id | doaj.art-87681801a6e04f41b386b4993d2affe5 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-10T14:19:33Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-87681801a6e04f41b386b4993d2affe52023-11-20T23:29:11ZengMDPI AGChildren2227-90672020-12-0171227210.3390/children7120272Sex Hormone-Binding Globulin Is Associated with Obesity and Dyslipidemia in Prepubertal ChildrenGihong Park0Kyungchul Song1Youngha Choi2Jun Suk Oh3Han Saem Choi4Junghwan Suh5Ahreum Kwon6Ho-Seong Kim7Hyun Wook Chae8Department of Pediatrics, Severance Children’s Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul 03722, KoreaDepartment of Pediatrics, Severance Children’s Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul 03722, KoreaDepartment of Pediatrics, Severance Children’s Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul 03722, KoreaDepartment of Pediatrics, Severance Children’s Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul 03722, KoreaDepartment of Pediatrics, Severance Children’s Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul 03722, KoreaDepartment of Pediatrics, Severance Children’s Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul 03722, KoreaDepartment of Pediatrics, Severance Children’s Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul 03722, KoreaDepartment of Pediatrics, Severance Children’s Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul 03722, KoreaDepartment of Pediatrics, Severance Children’s Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul 03722, KoreaSex hormone-binding globulin (SHBG) is associated with age, sex, and puberty. The association of SHBG with various diseases has been suggested nowadays, however, the relationships in prepubertal children have not been sufficiently investigated. This study analyzed the relationship of SHBG with body mass index (BMI) and plasma lipid levels in prepubertal children. We evaluated the association of SHBG with BMI among the 693 prepubertal children subdivided into normal, overweight, and obese groups, with plasma lipid levels among the children subdivided into normal and dyslipidemia groups. The obese and overweight group had lower SHBG levels than the normal BMI group in both sexes. The dyslipidemia group included subjects with low high-density lipoprotein cholesterol (HDL-C), high triglycerides (TG), or a high atherogenic index of plasma (AIP); this group had lower SHBG than the normal lipid group. SHBG was positively correlated with HDL-C, and negatively correlated with TG and AIP. After adjusting for BMI, SHBG was positively correlated with HDL-C and negatively correlated with TG and AIP in all groups. In conclusion, SHBG levels are closely correlated with BMI in prepubertal children. SHBG may play a meaningful role in the decrease in HDL-C and increase in TG during prepubertal age.https://www.mdpi.com/2227-9067/7/12/272sex hormone-binding globulinobesitydyslipidemiaslipidschild |
| spellingShingle | Gihong Park Kyungchul Song Youngha Choi Jun Suk Oh Han Saem Choi Junghwan Suh Ahreum Kwon Ho-Seong Kim Hyun Wook Chae Sex Hormone-Binding Globulin Is Associated with Obesity and Dyslipidemia in Prepubertal Children Children sex hormone-binding globulin obesity dyslipidemias lipids child |
| title | Sex Hormone-Binding Globulin Is Associated with Obesity and Dyslipidemia in Prepubertal Children |
| title_full | Sex Hormone-Binding Globulin Is Associated with Obesity and Dyslipidemia in Prepubertal Children |
| title_fullStr | Sex Hormone-Binding Globulin Is Associated with Obesity and Dyslipidemia in Prepubertal Children |
| title_full_unstemmed | Sex Hormone-Binding Globulin Is Associated with Obesity and Dyslipidemia in Prepubertal Children |
| title_short | Sex Hormone-Binding Globulin Is Associated with Obesity and Dyslipidemia in Prepubertal Children |
| title_sort | sex hormone binding globulin is associated with obesity and dyslipidemia in prepubertal children |
| topic | sex hormone-binding globulin obesity dyslipidemias lipids child |
| url | https://www.mdpi.com/2227-9067/7/12/272 |
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