EGFR-mutated, metastatic pulmonary pleomorphic carcinoma successfully treated with afatinib
Pulmonary pleomorphic carcinoma (PPC) has an aggressive clinical course and poor prognosis mainly because of the difficulty in achieving therapeutic effects. Despite a small fraction of patients with PPC possessing an epidermal growth factor receptor (EGFR) activating mutation, only a limited number...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-06-01
|
| Series: | Current Problems in Cancer: Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666621922000242 |
| _version_ | 1811226293469970432 |
|---|---|
| author | Akira Kawamura Yuko Tanaka Yusuke Inoue Takashi Tsuchida Mineo Katsumata Masato Karayama Hironao Hozumi Yuzo Suzuki Kazuki Furuhashi Noriyuki Enomoto Tomoyuki Fujisawa Yutaro Nakamura Naoki Inui Takafumi Suda |
| author_facet | Akira Kawamura Yuko Tanaka Yusuke Inoue Takashi Tsuchida Mineo Katsumata Masato Karayama Hironao Hozumi Yuzo Suzuki Kazuki Furuhashi Noriyuki Enomoto Tomoyuki Fujisawa Yutaro Nakamura Naoki Inui Takafumi Suda |
| author_sort | Akira Kawamura |
| collection | DOAJ |
| description | Pulmonary pleomorphic carcinoma (PPC) has an aggressive clinical course and poor prognosis mainly because of the difficulty in achieving therapeutic effects. Despite a small fraction of patients with PPC possessing an epidermal growth factor receptor (EGFR) activating mutation, only a limited number of studies have reported the efficacy of EGFR tyrosine kinase inhibitors in those patients. Here, we present successful treatment with first-line afatinib in a patient with EGFR mutation-positive, metastatic PPC. |
| first_indexed | 2024-04-12T09:22:46Z |
| format | Article |
| id | doaj.art-876853243ea74f94b3de5136b59d09ca |
| institution | Directory Open Access Journal |
| issn | 2666-6219 |
| language | English |
| last_indexed | 2024-04-12T09:22:46Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Problems in Cancer: Case Reports |
| spelling | doaj.art-876853243ea74f94b3de5136b59d09ca2022-12-22T03:38:34ZengElsevierCurrent Problems in Cancer: Case Reports2666-62192022-06-016100160EGFR-mutated, metastatic pulmonary pleomorphic carcinoma successfully treated with afatinibAkira Kawamura0Yuko Tanaka1Yusuke Inoue2Takashi Tsuchida3Mineo Katsumata4Masato Karayama5Hironao Hozumi6Yuzo Suzuki7Kazuki Furuhashi8Noriyuki Enomoto9Tomoyuki Fujisawa10Yutaro Nakamura11Naoki Inui12Takafumi Suda13Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, JapanSecond Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan; Corresponding author.Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan; Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Hamamatsu, Japan.Department of Diagnostic Pathology, Hamamatsu University School of Medicine, Hamamatsu, Japan.Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, JapanSecond Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan; Department of Clinical Oncology, Hamamatsu University School of Medicine, Hamamatsu, Japan.Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, JapanSecond Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, JapanSecond Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan; Department of Laboratory Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, JapanSecond Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, JapanSecond Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, JapanSecond Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan; Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Hamamatsu, Japan.Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, JapanPulmonary pleomorphic carcinoma (PPC) has an aggressive clinical course and poor prognosis mainly because of the difficulty in achieving therapeutic effects. Despite a small fraction of patients with PPC possessing an epidermal growth factor receptor (EGFR) activating mutation, only a limited number of studies have reported the efficacy of EGFR tyrosine kinase inhibitors in those patients. Here, we present successful treatment with first-line afatinib in a patient with EGFR mutation-positive, metastatic PPC.http://www.sciencedirect.com/science/article/pii/S2666621922000242Epidermal growth factor receptorL858RNon-small cell lung cancerSpindle cellTyrosine kinase inhibitors |
| spellingShingle | Akira Kawamura Yuko Tanaka Yusuke Inoue Takashi Tsuchida Mineo Katsumata Masato Karayama Hironao Hozumi Yuzo Suzuki Kazuki Furuhashi Noriyuki Enomoto Tomoyuki Fujisawa Yutaro Nakamura Naoki Inui Takafumi Suda EGFR-mutated, metastatic pulmonary pleomorphic carcinoma successfully treated with afatinib Current Problems in Cancer: Case Reports Epidermal growth factor receptor L858R Non-small cell lung cancer Spindle cell Tyrosine kinase inhibitors |
| title | EGFR-mutated, metastatic pulmonary pleomorphic carcinoma successfully treated with afatinib |
| title_full | EGFR-mutated, metastatic pulmonary pleomorphic carcinoma successfully treated with afatinib |
| title_fullStr | EGFR-mutated, metastatic pulmonary pleomorphic carcinoma successfully treated with afatinib |
| title_full_unstemmed | EGFR-mutated, metastatic pulmonary pleomorphic carcinoma successfully treated with afatinib |
| title_short | EGFR-mutated, metastatic pulmonary pleomorphic carcinoma successfully treated with afatinib |
| title_sort | egfr mutated metastatic pulmonary pleomorphic carcinoma successfully treated with afatinib |
| topic | Epidermal growth factor receptor L858R Non-small cell lung cancer Spindle cell Tyrosine kinase inhibitors |
| url | http://www.sciencedirect.com/science/article/pii/S2666621922000242 |
| work_keys_str_mv | AT akirakawamura egfrmutatedmetastaticpulmonarypleomorphiccarcinomasuccessfullytreatedwithafatinib AT yukotanaka egfrmutatedmetastaticpulmonarypleomorphiccarcinomasuccessfullytreatedwithafatinib AT yusukeinoue egfrmutatedmetastaticpulmonarypleomorphiccarcinomasuccessfullytreatedwithafatinib AT takashitsuchida egfrmutatedmetastaticpulmonarypleomorphiccarcinomasuccessfullytreatedwithafatinib AT mineokatsumata egfrmutatedmetastaticpulmonarypleomorphiccarcinomasuccessfullytreatedwithafatinib AT masatokarayama egfrmutatedmetastaticpulmonarypleomorphiccarcinomasuccessfullytreatedwithafatinib AT hironaohozumi egfrmutatedmetastaticpulmonarypleomorphiccarcinomasuccessfullytreatedwithafatinib AT yuzosuzuki egfrmutatedmetastaticpulmonarypleomorphiccarcinomasuccessfullytreatedwithafatinib AT kazukifuruhashi egfrmutatedmetastaticpulmonarypleomorphiccarcinomasuccessfullytreatedwithafatinib AT noriyukienomoto egfrmutatedmetastaticpulmonarypleomorphiccarcinomasuccessfullytreatedwithafatinib AT tomoyukifujisawa egfrmutatedmetastaticpulmonarypleomorphiccarcinomasuccessfullytreatedwithafatinib AT yutaronakamura egfrmutatedmetastaticpulmonarypleomorphiccarcinomasuccessfullytreatedwithafatinib AT naokiinui egfrmutatedmetastaticpulmonarypleomorphiccarcinomasuccessfullytreatedwithafatinib AT takafumisuda egfrmutatedmetastaticpulmonarypleomorphiccarcinomasuccessfullytreatedwithafatinib |