Experience-dependent shaping of hippocampal CA1 intracellular activity in novel and familiar environments
The hippocampus is critical for producing stable representations of familiar spaces. How these representations arise is poorly understood, largely because changes to hippocampal inputs have not been measured during spatial learning. Here, using intracellular recording, we monitored inputs and plasti...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2017-07-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/23040 |
| _version_ | 1811199629150126080 |
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| author | Jeremy D Cohen Mark Bolstad Albert K Lee |
| author_facet | Jeremy D Cohen Mark Bolstad Albert K Lee |
| author_sort | Jeremy D Cohen |
| collection | DOAJ |
| description | The hippocampus is critical for producing stable representations of familiar spaces. How these representations arise is poorly understood, largely because changes to hippocampal inputs have not been measured during spatial learning. Here, using intracellular recording, we monitored inputs and plasticity-inducing complex spikes (CSs) in CA1 neurons while mice explored novel and familiar virtual environments. Inputs driving place field spiking increased in amplitude – often suddenly – during novel environment exploration. However, these increases were not sustained in familiar environments. Rather, the spatial tuning of inputs became increasingly similar across repeated traversals of the environment with experience – both within fields and throughout the whole environment. In novel environments, CSs were not necessary for place field formation. Our findings support a model in which initial inhomogeneities in inputs are amplified to produce robust place field activity, then plasticity refines this representation into one with less strongly modulated, but more stable, inputs for long-term storage. |
| first_indexed | 2024-04-12T01:50:35Z |
| format | Article |
| id | doaj.art-8769b85aa32c4013812bc18d8bafed3e |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T01:50:35Z |
| publishDate | 2017-07-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-8769b85aa32c4013812bc18d8bafed3e2022-12-22T03:52:57ZengeLife Sciences Publications LtdeLife2050-084X2017-07-01610.7554/eLife.23040Experience-dependent shaping of hippocampal CA1 intracellular activity in novel and familiar environmentsJeremy D Cohen0https://orcid.org/0000-0003-4961-222XMark Bolstad1Albert K Lee2https://orcid.org/0000-0003-4332-8332Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United StatesJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United StatesJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United StatesThe hippocampus is critical for producing stable representations of familiar spaces. How these representations arise is poorly understood, largely because changes to hippocampal inputs have not been measured during spatial learning. Here, using intracellular recording, we monitored inputs and plasticity-inducing complex spikes (CSs) in CA1 neurons while mice explored novel and familiar virtual environments. Inputs driving place field spiking increased in amplitude – often suddenly – during novel environment exploration. However, these increases were not sustained in familiar environments. Rather, the spatial tuning of inputs became increasingly similar across repeated traversals of the environment with experience – both within fields and throughout the whole environment. In novel environments, CSs were not necessary for place field formation. Our findings support a model in which initial inhomogeneities in inputs are amplified to produce robust place field activity, then plasticity refines this representation into one with less strongly modulated, but more stable, inputs for long-term storage.https://elifesciences.org/articles/23040hippocampusCA1place cellspatial memoryintracellularwhole-cell |
| spellingShingle | Jeremy D Cohen Mark Bolstad Albert K Lee Experience-dependent shaping of hippocampal CA1 intracellular activity in novel and familiar environments eLife hippocampus CA1 place cell spatial memory intracellular whole-cell |
| title | Experience-dependent shaping of hippocampal CA1 intracellular activity in novel and familiar environments |
| title_full | Experience-dependent shaping of hippocampal CA1 intracellular activity in novel and familiar environments |
| title_fullStr | Experience-dependent shaping of hippocampal CA1 intracellular activity in novel and familiar environments |
| title_full_unstemmed | Experience-dependent shaping of hippocampal CA1 intracellular activity in novel and familiar environments |
| title_short | Experience-dependent shaping of hippocampal CA1 intracellular activity in novel and familiar environments |
| title_sort | experience dependent shaping of hippocampal ca1 intracellular activity in novel and familiar environments |
| topic | hippocampus CA1 place cell spatial memory intracellular whole-cell |
| url | https://elifesciences.org/articles/23040 |
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