Extract of Synedrella nodiflora (L) Gaertn exhibits antipsychotic properties in murine models of psychosis
Abstract Background The hydro-ethanolic whole plant extract of Synedrella nodiflora (SNE) has demonstrated anticonvulsant, sedative and analgesic effects. Preliminary studies conducted in animals, SNE significantly decreased stereotypic behaviours suggesting antipsychotic potential. Coupled with the...
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| Format: | Article |
| Language: | English |
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BMC
2017-08-01
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| Series: | BMC Complementary and Alternative Medicine |
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| Online Access: | http://link.springer.com/article/10.1186/s12906-017-1901-2 |
| _version_ | 1828860526501822464 |
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| author | Patrick Amoateng Samuel Adjei Dorcas Osei-safo Kennedy K. E. Kukuia Emelia Oppong Bekoe Thomas K. Karikari Samuel B. Kombian |
| author_facet | Patrick Amoateng Samuel Adjei Dorcas Osei-safo Kennedy K. E. Kukuia Emelia Oppong Bekoe Thomas K. Karikari Samuel B. Kombian |
| author_sort | Patrick Amoateng |
| collection | DOAJ |
| description | Abstract Background The hydro-ethanolic whole plant extract of Synedrella nodiflora (SNE) has demonstrated anticonvulsant, sedative and analgesic effects. Preliminary studies conducted in animals, SNE significantly decreased stereotypic behaviours suggesting antipsychotic potential. Coupled with the central nervous system depressant effects of SNE, we hypothesized that it may have utility in the management of psychosis. The present study therefore investigated the antipsychotic potential of the SNE in several murine models of psychosis. Method The primary central nervous system activities of SNE (30–3000 mg/kg, p.o) were investigated using the Irwin’s test. The novelty-induced rearing, locomotion and stereotypy counts provoked by SNE (100–1000 mg/kg, p.o) were conducted using the open-field paradigm. The antipsychotic test models used in the screening of SNE (100–1000 mg/kg, p.o) included apomorphine-induced stereotypy, rearing, locomotion and cage climbing activities. The combined effects of a low dose of SNE (100 mg/kg) with various doses of haloperidol and chlorpromazine were analysed using the apomorphine-induced cage climbing and stereotypy, respectively. The ability of SNE to cause catalepsy in naïve mice as well as its effect on haloperidol-induced catalepsy was assessed. Results SNE showed acetylcholine-like and serotonin-like activities in the Irwin test, with sedation occurring at high doses. SNE significantly reduced the frequencies of novelty- and apomorphine-induced rearing and locomotion; stereotypy behaviour and the frequency and duration of apomorphine-induced cage climbing in mice. In all the tests performed, SNE was less potent than the reference drugs used (chlorpromazine and haloperidol). In addition, SNE potentiated the effects of haloperidol and chlorpromazine on apomorphine-induced cage climbing and stereotypy activities in mice. Conclusion SNE, while exhibiting antipsychotic properties itself, can also potentiate the antipsychotic effects of chlorpromazine and haloperidol. |
| first_indexed | 2024-12-13T02:40:38Z |
| format | Article |
| id | doaj.art-876b3e6cf4fa49c59ecafdd81591957e |
| institution | Directory Open Access Journal |
| issn | 1472-6882 |
| language | English |
| last_indexed | 2024-12-13T02:40:38Z |
| publishDate | 2017-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Complementary and Alternative Medicine |
| spelling | doaj.art-876b3e6cf4fa49c59ecafdd81591957e2022-12-22T00:02:18ZengBMCBMC Complementary and Alternative Medicine1472-68822017-08-0117111410.1186/s12906-017-1901-2Extract of Synedrella nodiflora (L) Gaertn exhibits antipsychotic properties in murine models of psychosisPatrick Amoateng0Samuel Adjei1Dorcas Osei-safo2Kennedy K. E. Kukuia3Emelia Oppong Bekoe4Thomas K. Karikari5Samuel B. Kombian6Department of Pharmacology and Toxicology, School of Pharmacy, College of Health Sciences, University of GhanaDepartment of Animal Experimentation, Noguchi Memorial Institute for Medical Research (NMIMR), College of Health Sciences, University of GhanaDepartment of Chemistry, School of Physical and Mathematical Sciences, College of Basic and Applied Sciences, University of GhanaDepartment of Pharmacology and Toxicology, School of Pharmacy, College of Health Sciences, University of GhanaDepartment of Pharmacognosy and Herbal Medicine, School of Pharmacy, College of Health Sciences, University of GhanaSchool of Life Sciences, University of WarwickDepartment of Pharmacology and Therapeutics, Faculty of Pharmacy, Health Science Center, Kuwait UniversityAbstract Background The hydro-ethanolic whole plant extract of Synedrella nodiflora (SNE) has demonstrated anticonvulsant, sedative and analgesic effects. Preliminary studies conducted in animals, SNE significantly decreased stereotypic behaviours suggesting antipsychotic potential. Coupled with the central nervous system depressant effects of SNE, we hypothesized that it may have utility in the management of psychosis. The present study therefore investigated the antipsychotic potential of the SNE in several murine models of psychosis. Method The primary central nervous system activities of SNE (30–3000 mg/kg, p.o) were investigated using the Irwin’s test. The novelty-induced rearing, locomotion and stereotypy counts provoked by SNE (100–1000 mg/kg, p.o) were conducted using the open-field paradigm. The antipsychotic test models used in the screening of SNE (100–1000 mg/kg, p.o) included apomorphine-induced stereotypy, rearing, locomotion and cage climbing activities. The combined effects of a low dose of SNE (100 mg/kg) with various doses of haloperidol and chlorpromazine were analysed using the apomorphine-induced cage climbing and stereotypy, respectively. The ability of SNE to cause catalepsy in naïve mice as well as its effect on haloperidol-induced catalepsy was assessed. Results SNE showed acetylcholine-like and serotonin-like activities in the Irwin test, with sedation occurring at high doses. SNE significantly reduced the frequencies of novelty- and apomorphine-induced rearing and locomotion; stereotypy behaviour and the frequency and duration of apomorphine-induced cage climbing in mice. In all the tests performed, SNE was less potent than the reference drugs used (chlorpromazine and haloperidol). In addition, SNE potentiated the effects of haloperidol and chlorpromazine on apomorphine-induced cage climbing and stereotypy activities in mice. Conclusion SNE, while exhibiting antipsychotic properties itself, can also potentiate the antipsychotic effects of chlorpromazine and haloperidol.http://link.springer.com/article/10.1186/s12906-017-1901-2Synedrella nodiflorachlorpromazinehaloperidolapomorphinestereotypyantipsychotic |
| spellingShingle | Patrick Amoateng Samuel Adjei Dorcas Osei-safo Kennedy K. E. Kukuia Emelia Oppong Bekoe Thomas K. Karikari Samuel B. Kombian Extract of Synedrella nodiflora (L) Gaertn exhibits antipsychotic properties in murine models of psychosis BMC Complementary and Alternative Medicine Synedrella nodiflora chlorpromazine haloperidol apomorphine stereotypy antipsychotic |
| title | Extract of Synedrella nodiflora (L) Gaertn exhibits antipsychotic properties in murine models of psychosis |
| title_full | Extract of Synedrella nodiflora (L) Gaertn exhibits antipsychotic properties in murine models of psychosis |
| title_fullStr | Extract of Synedrella nodiflora (L) Gaertn exhibits antipsychotic properties in murine models of psychosis |
| title_full_unstemmed | Extract of Synedrella nodiflora (L) Gaertn exhibits antipsychotic properties in murine models of psychosis |
| title_short | Extract of Synedrella nodiflora (L) Gaertn exhibits antipsychotic properties in murine models of psychosis |
| title_sort | extract of synedrella nodiflora l gaertn exhibits antipsychotic properties in murine models of psychosis |
| topic | Synedrella nodiflora chlorpromazine haloperidol apomorphine stereotypy antipsychotic |
| url | http://link.springer.com/article/10.1186/s12906-017-1901-2 |
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