A Systematic Search and Mapping Review of Studies on Intracerebral Microdialysis of Amino Acids, and Systematized Review of Studies on Circadian Rhythms
Background: Microdialysis can be used to measure amino acids in the extracellular space 'in vivo', based on the principle of diffusion. Variations in experimental set-up result in variations in baseline levels of the compounds measured. Variations may also be due to circadian rhythms. Meth...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Ubiquity Press
2018-10-01
|
| Series: | Journal of Circadian Rhythms |
| Subjects: | |
| Online Access: | https://www.jcircadianrhythms.com/articles/172 |
| _version_ | 1819175038671126528 |
|---|---|
| author | Cathalijn H. C. Leenaars Jennifer Freymann Koen Jakobs Julia M. L. Menon Thomas J. Van Ee Janneke Elzinga Rosalie W. M. Kempkes Bea Zoer Pim W. H. I. M. Drinkenburg |
| author_facet | Cathalijn H. C. Leenaars Jennifer Freymann Koen Jakobs Julia M. L. Menon Thomas J. Van Ee Janneke Elzinga Rosalie W. M. Kempkes Bea Zoer Pim W. H. I. M. Drinkenburg |
| author_sort | Cathalijn H. C. Leenaars |
| collection | DOAJ |
| description | Background: Microdialysis can be used to measure amino acids in the extracellular space 'in vivo', based on the principle of diffusion. Variations in experimental set-up result in variations in baseline levels of the compounds measured. Variations may also be due to circadian rhythms. Method: We systematically searched and mapped the literature on all studies reporting baseline microdialysis measurements of histamine and the amino acids asparagine, aspartate, GABA, glutamate, glutamine, glycine, proline and taurine. We fully reviewed the studies describing circadian rhythms for histamine and the selected amino acids. Results: We retrieved 2331 papers describing baseline measurements of one or more of the compounds of interest. We provide a numerical summary and lists of the publications by compound. We retrieved 11 references describing studies on the circadian rhythms of the compounds of interest. Aspartate, glutamate and histamine are generally higher during the dark than during the light phase in nocturnal rodents. For glutamine, no rhythmicity was observed. For GABA, the results were too inconsistent to generalise. For asparagine, glycine, proline and taurine, insufficient data are available. Conclusion: The literature on intracerebral microdialysis measurements of the amino acids is vast, but certain primary studies are still warranted. Future systematic reviews on the individual compounds can shed light on the effects of experimental variations on baseline concentrations. |
| first_indexed | 2024-12-22T20:48:31Z |
| format | Article |
| id | doaj.art-876b4100d38645d59a71072573cba285 |
| institution | Directory Open Access Journal |
| issn | 1740-3391 |
| language | English |
| last_indexed | 2024-12-22T20:48:31Z |
| publishDate | 2018-10-01 |
| publisher | Ubiquity Press |
| record_format | Article |
| series | Journal of Circadian Rhythms |
| spelling | doaj.art-876b4100d38645d59a71072573cba2852022-12-21T18:13:10ZengUbiquity PressJournal of Circadian Rhythms1740-33912018-10-0116110.5334/jcr.172150A Systematic Search and Mapping Review of Studies on Intracerebral Microdialysis of Amino Acids, and Systematized Review of Studies on Circadian RhythmsCathalijn H. C. Leenaars0Jennifer Freymann1Koen Jakobs2Julia M. L. Menon3Thomas J. Van Ee4Janneke Elzinga5Rosalie W. M. Kempkes6Bea Zoer7Pim W. H. I. M. Drinkenburg8RadboudUMC, Utrecht University, Utrecht and Nijmegen, NL; Hannover Medical School, HannoverUniversity of Veterinary MedicineRadboudUMC, Utrecht University, Utrecht and NijmegenRadboudUMC, Utrecht University, Utrecht and NijmegenRadboudUMC, Utrecht University, Utrecht and NijmegenRadboudUMC, Utrecht University, Utrecht and NijmegenRadboudUMC, Utrecht University, Utrecht and NijmegenRadboudUMC, Utrecht University, Utrecht and NijmegenJanssen Research and Development, A Division of Janssen Pharmaceutica NVBackground: Microdialysis can be used to measure amino acids in the extracellular space 'in vivo', based on the principle of diffusion. Variations in experimental set-up result in variations in baseline levels of the compounds measured. Variations may also be due to circadian rhythms. Method: We systematically searched and mapped the literature on all studies reporting baseline microdialysis measurements of histamine and the amino acids asparagine, aspartate, GABA, glutamate, glutamine, glycine, proline and taurine. We fully reviewed the studies describing circadian rhythms for histamine and the selected amino acids. Results: We retrieved 2331 papers describing baseline measurements of one or more of the compounds of interest. We provide a numerical summary and lists of the publications by compound. We retrieved 11 references describing studies on the circadian rhythms of the compounds of interest. Aspartate, glutamate and histamine are generally higher during the dark than during the light phase in nocturnal rodents. For glutamine, no rhythmicity was observed. For GABA, the results were too inconsistent to generalise. For asparagine, glycine, proline and taurine, insufficient data are available. Conclusion: The literature on intracerebral microdialysis measurements of the amino acids is vast, but certain primary studies are still warranted. Future systematic reviews on the individual compounds can shed light on the effects of experimental variations on baseline concentrations.https://www.jcircadianrhythms.com/articles/172Amino acidsHistamineMicrodialysisSystematic mapcircadian rhythm |
| spellingShingle | Cathalijn H. C. Leenaars Jennifer Freymann Koen Jakobs Julia M. L. Menon Thomas J. Van Ee Janneke Elzinga Rosalie W. M. Kempkes Bea Zoer Pim W. H. I. M. Drinkenburg A Systematic Search and Mapping Review of Studies on Intracerebral Microdialysis of Amino Acids, and Systematized Review of Studies on Circadian Rhythms Journal of Circadian Rhythms Amino acids Histamine Microdialysis Systematic map circadian rhythm |
| title | A Systematic Search and Mapping Review of Studies on Intracerebral Microdialysis of Amino Acids, and Systematized Review of Studies on Circadian Rhythms |
| title_full | A Systematic Search and Mapping Review of Studies on Intracerebral Microdialysis of Amino Acids, and Systematized Review of Studies on Circadian Rhythms |
| title_fullStr | A Systematic Search and Mapping Review of Studies on Intracerebral Microdialysis of Amino Acids, and Systematized Review of Studies on Circadian Rhythms |
| title_full_unstemmed | A Systematic Search and Mapping Review of Studies on Intracerebral Microdialysis of Amino Acids, and Systematized Review of Studies on Circadian Rhythms |
| title_short | A Systematic Search and Mapping Review of Studies on Intracerebral Microdialysis of Amino Acids, and Systematized Review of Studies on Circadian Rhythms |
| title_sort | systematic search and mapping review of studies on intracerebral microdialysis of amino acids and systematized review of studies on circadian rhythms |
| topic | Amino acids Histamine Microdialysis Systematic map circadian rhythm |
| url | https://www.jcircadianrhythms.com/articles/172 |
| work_keys_str_mv | AT cathalijnhcleenaars asystematicsearchandmappingreviewofstudiesonintracerebralmicrodialysisofaminoacidsandsystematizedreviewofstudiesoncircadianrhythms AT jenniferfreymann asystematicsearchandmappingreviewofstudiesonintracerebralmicrodialysisofaminoacidsandsystematizedreviewofstudiesoncircadianrhythms AT koenjakobs asystematicsearchandmappingreviewofstudiesonintracerebralmicrodialysisofaminoacidsandsystematizedreviewofstudiesoncircadianrhythms AT juliamlmenon asystematicsearchandmappingreviewofstudiesonintracerebralmicrodialysisofaminoacidsandsystematizedreviewofstudiesoncircadianrhythms AT thomasjvanee asystematicsearchandmappingreviewofstudiesonintracerebralmicrodialysisofaminoacidsandsystematizedreviewofstudiesoncircadianrhythms AT jannekeelzinga asystematicsearchandmappingreviewofstudiesonintracerebralmicrodialysisofaminoacidsandsystematizedreviewofstudiesoncircadianrhythms AT rosaliewmkempkes asystematicsearchandmappingreviewofstudiesonintracerebralmicrodialysisofaminoacidsandsystematizedreviewofstudiesoncircadianrhythms AT beazoer asystematicsearchandmappingreviewofstudiesonintracerebralmicrodialysisofaminoacidsandsystematizedreviewofstudiesoncircadianrhythms AT pimwhimdrinkenburg asystematicsearchandmappingreviewofstudiesonintracerebralmicrodialysisofaminoacidsandsystematizedreviewofstudiesoncircadianrhythms AT cathalijnhcleenaars systematicsearchandmappingreviewofstudiesonintracerebralmicrodialysisofaminoacidsandsystematizedreviewofstudiesoncircadianrhythms AT jenniferfreymann systematicsearchandmappingreviewofstudiesonintracerebralmicrodialysisofaminoacidsandsystematizedreviewofstudiesoncircadianrhythms AT koenjakobs systematicsearchandmappingreviewofstudiesonintracerebralmicrodialysisofaminoacidsandsystematizedreviewofstudiesoncircadianrhythms AT juliamlmenon systematicsearchandmappingreviewofstudiesonintracerebralmicrodialysisofaminoacidsandsystematizedreviewofstudiesoncircadianrhythms AT thomasjvanee systematicsearchandmappingreviewofstudiesonintracerebralmicrodialysisofaminoacidsandsystematizedreviewofstudiesoncircadianrhythms AT jannekeelzinga systematicsearchandmappingreviewofstudiesonintracerebralmicrodialysisofaminoacidsandsystematizedreviewofstudiesoncircadianrhythms AT rosaliewmkempkes systematicsearchandmappingreviewofstudiesonintracerebralmicrodialysisofaminoacidsandsystematizedreviewofstudiesoncircadianrhythms AT beazoer systematicsearchandmappingreviewofstudiesonintracerebralmicrodialysisofaminoacidsandsystematizedreviewofstudiesoncircadianrhythms AT pimwhimdrinkenburg systematicsearchandmappingreviewofstudiesonintracerebralmicrodialysisofaminoacidsandsystematizedreviewofstudiesoncircadianrhythms |