Modern combined hormonal therapy in early postmenopause women
Aim. To study the effects of hormone replacement therapy (HRT) with a combination of estradiol and drospirenone on cardiometabolic risk levels and subclinical vascular pathology among women in early postmenopause. Material and methods. In total, 84 women in early postmenopause, who had given informe...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2012-08-01
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| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1864 |
| _version_ | 1797882606153367552 |
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| author | V. B. Mychka M. Yu. Kirillova I. V. Kuznetsova N. A. Voychenko A. A. Fedorovich T. V. Balakhonova Yu. V. Prokhorova V. A. Vyshivanyuk |
| author_facet | V. B. Mychka M. Yu. Kirillova I. V. Kuznetsova N. A. Voychenko A. A. Fedorovich T. V. Balakhonova Yu. V. Prokhorova V. A. Vyshivanyuk |
| author_sort | V. B. Mychka |
| collection | DOAJ |
| description | Aim. To study the effects of hormone replacement therapy (HRT) with a combination of estradiol and drospirenone on cardiometabolic risk levels and subclinical vascular pathology among women in early postmenopause. Material and methods. In total, 84 women in early postmenopause, who had given informed consent and underwent a standard examination, were divided into two groups: Group I (with gynaecologist-confirmed indications for HRT with Angeliq (1 mg 17 β-estradiol and 2 mg drospirenone)) and Group II (no HRT). All participants underwent the assessment of metabolic parameters, visceral obesity, intima-media thickness (IMT) of common carotid arteries (CCA), arterial stiffness, and microcirculation (MC) status at baseline and 12 months later. Results. HRT demonstrated beneficial effects on autonomic regulation, lipid metabolism, CCA IMT, and arterial stiffness. It was also associated with a reduction in visceral obesity, some antihypertensive effect, and an increase in the MC dilatation reserve in postmenopausal women. Conclusion. Low-dose combined hormone therapy with drospirenone and estradiol could be recommended to a specific clinical group of women in early postmenopause. |
| first_indexed | 2024-04-10T03:37:27Z |
| format | Article |
| id | doaj.art-876ce8f005884665801287a82638e2be |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2024-04-10T03:37:27Z |
| publishDate | 2012-08-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-876ce8f005884665801287a82638e2be2023-03-13T07:23:21Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252012-08-01114425110.15829/1728-8800-2012-4-42-511579Modern combined hormonal therapy in early postmenopause womenV. B. Mychka0M. Yu. Kirillova1I. V. Kuznetsova2N. A. Voychenko3A. A. Fedorovich4T. V. Balakhonova5Yu. V. Prokhorova6V. A. Vyshivanyuk7НИИ кардиологии им. А. Л.Мясникова ФГБУ «Российский кардиологический научно-производственный комплекс» Минздравсоцразвития России, МоскваНИИ кардиологии им. А. Л.Мясникова ФГБУ «Российский кардиологический научно-производственный комплекс» Минздравсоцразвития России, МоскваГБОУ ДМО «Российская медицинская академия последипломного образования», МоскваГБОУ ВПО «Первый Московский государственный медицинский университет им. И. М.Сеченова» Минздравсоцразвития России, МоскваНИИ кардиологии им. А. Л.Мясникова ФГБУ «Российский кардиологический научно-производственный комплекс» Минздравсоцразвития России, МоскваНИИ кардиологии им. А. Л.Мясникова ФГБУ «Российский кардиологический научно-производственный комплекс» Минздравсоцразвития России, МоскваГБОУ ВПО «Московский государственный медико-стоматологический университет» Минздравсоцразвития России, МоскваГБОУ ВПО «Московский государственный медико-стоматологический университет» Минздравсоцразвития России, МоскваAim. To study the effects of hormone replacement therapy (HRT) with a combination of estradiol and drospirenone on cardiometabolic risk levels and subclinical vascular pathology among women in early postmenopause. Material and methods. In total, 84 women in early postmenopause, who had given informed consent and underwent a standard examination, were divided into two groups: Group I (with gynaecologist-confirmed indications for HRT with Angeliq (1 mg 17 β-estradiol and 2 mg drospirenone)) and Group II (no HRT). All participants underwent the assessment of metabolic parameters, visceral obesity, intima-media thickness (IMT) of common carotid arteries (CCA), arterial stiffness, and microcirculation (MC) status at baseline and 12 months later. Results. HRT demonstrated beneficial effects on autonomic regulation, lipid metabolism, CCA IMT, and arterial stiffness. It was also associated with a reduction in visceral obesity, some antihypertensive effect, and an increase in the MC dilatation reserve in postmenopausal women. Conclusion. Low-dose combined hormone therapy with drospirenone and estradiol could be recommended to a specific clinical group of women in early postmenopause.https://cardiovascular.elpub.ru/jour/article/view/1864метаболический синдромартериальная гипертониясердечно-сосудистые заболеванияпостменопаузазаместительная гормональная терапиядроспиренон |
| spellingShingle | V. B. Mychka M. Yu. Kirillova I. V. Kuznetsova N. A. Voychenko A. A. Fedorovich T. V. Balakhonova Yu. V. Prokhorova V. A. Vyshivanyuk Modern combined hormonal therapy in early postmenopause women Кардиоваскулярная терапия и профилактика метаболический синдром артериальная гипертония сердечно-сосудистые заболевания постменопауза заместительная гормональная терапия дроспиренон |
| title | Modern combined hormonal therapy in early postmenopause women |
| title_full | Modern combined hormonal therapy in early postmenopause women |
| title_fullStr | Modern combined hormonal therapy in early postmenopause women |
| title_full_unstemmed | Modern combined hormonal therapy in early postmenopause women |
| title_short | Modern combined hormonal therapy in early postmenopause women |
| title_sort | modern combined hormonal therapy in early postmenopause women |
| topic | метаболический синдром артериальная гипертония сердечно-сосудистые заболевания постменопауза заместительная гормональная терапия дроспиренон |
| url | https://cardiovascular.elpub.ru/jour/article/view/1864 |
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