Targeting the melanoma-associated antigen CSPG4 with HLA-C*07:01-restricted T-cell receptors

Targeting the melanoma-associated antigen CSPG4 with HLA-C*07:01-restricted T-cell receptors

IntorductionChondroitin sulfate proteoglycan 4 (CSPG4), also known as high molecular weight-melanoma associated antigen, is expressed in melanoma but also other tumor entities and constitutes an attractive target for immunotherapeutic approaches. While recent preclinical reports focused on anti-CSPG...

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Bibliographic Details
Main Authors: Korbinian N. Kropp, Martina Fatho, Enes Huduti, Marilena Faust, Silke Lübcke, Volker Lennerz, Annette Paschen, Matthias Theobald, Thomas Wölfel, Catherine Wölfel
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
tumor immunotherapy
T cell receptor (TCR)
CSPG4
chondroitin sulfate proteoglycan 4
TCR hemichain dominance
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1245559/full

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