Lipoprotein lipase expression, serum lipid and tissue lipid deposition in orally-administered glycyrrhizic acid-treated rats
<p>Abstract</p> <p>Background</p> <p>The metabolic syndrome (MetS) is a cluster of metabolic abnormalities comprising visceral obesity, dyslipidaemia and insulin resistance (IR). With the onset of IR, the expression of lipoprotein lipase (LPL), a key regulator of lipopr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2009-07-01
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| Series: | Lipids in Health and Disease |
| Online Access: | http://www.lipidworld.com/content/8/1/31 |
| _version_ | 1818789417933864960 |
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| author | Ton So Kadir Khalid Liong Shih Chia Yoke Lim Wai Syed Husain Sharifah |
| author_facet | Ton So Kadir Khalid Liong Shih Chia Yoke Lim Wai Syed Husain Sharifah |
| author_sort | Ton So |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The metabolic syndrome (MetS) is a cluster of metabolic abnormalities comprising visceral obesity, dyslipidaemia and insulin resistance (IR). With the onset of IR, the expression of lipoprotein lipase (LPL), a key regulator of lipoprotein metabolism, is reduced. Increased activation of glucocorticoid receptors results in MetS symptoms and is thus speculated to have a role in the pathophysiology of the MetS. Glycyrrhizic acid (GA), the bioactive constituent of licorice roots (<it>Glycyrrhiza glabra</it>) inhibits 11β-hydroxysteroid dehydrogenase type 1 that catalyzes the activation of glucocorticoids. Thus, oral administration of GA is postulated to ameliorate the MetS.</p> <p>Results</p> <p>In this study, daily oral administration of 50 mg/kg of GA for one week led to significant increase in LPL expression in the quadriceps femoris (<it>p </it>< 0.05) but non-significant increase in the abdominal muscle, kidney, liver, heart and the subcutaneous and visceral adipose tissues (<it>p </it>> 0.05) of the GA-treated rats compared to the control. Decrease in adipocyte size (<it>p </it>> 0.05) in both the visceral and subcutaneous adipose tissue depots accompanies such selective induction of LPL expression. Consistent improvement in serum lipid parameters was also observed, with decrease in serum free fatty acid, triacylglycerol, total cholesterol and LDL-cholesterol but elevated HDL-cholesterol (<it>p </it>> 0.05). Histological analysis using tissue lipid staining with Oil Red O showed significant decrease in lipid deposition in the abdominal muscle and quadriceps femoris (<it>p </it>< 0.05) but non-significant decrease in the heart, kidney and liver (<it>p </it>> 0.05).</p> <p>Conclusion</p> <p>Results from this study may imply that GA could counteract the development of visceral obesity and improve dyslipidaemia via selective induction of tissue LPL expression and a positive shift in serum lipid parameters respectively, and retard the development of IR associated with tissue steatosis.</p> |
| first_indexed | 2024-12-18T14:39:14Z |
| format | Article |
| id | doaj.art-876d460a64d745feb28e506f6fde7c8b |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-18T14:39:14Z |
| publishDate | 2009-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-876d460a64d745feb28e506f6fde7c8b2022-12-21T21:04:26ZengBMCLipids in Health and Disease1476-511X2009-07-01813110.1186/1476-511X-8-31Lipoprotein lipase expression, serum lipid and tissue lipid deposition in orally-administered glycyrrhizic acid-treated ratsTon SoKadir KhalidLiong ShihChia YokeLim WaiSyed Husain Sharifah<p>Abstract</p> <p>Background</p> <p>The metabolic syndrome (MetS) is a cluster of metabolic abnormalities comprising visceral obesity, dyslipidaemia and insulin resistance (IR). With the onset of IR, the expression of lipoprotein lipase (LPL), a key regulator of lipoprotein metabolism, is reduced. Increased activation of glucocorticoid receptors results in MetS symptoms and is thus speculated to have a role in the pathophysiology of the MetS. Glycyrrhizic acid (GA), the bioactive constituent of licorice roots (<it>Glycyrrhiza glabra</it>) inhibits 11β-hydroxysteroid dehydrogenase type 1 that catalyzes the activation of glucocorticoids. Thus, oral administration of GA is postulated to ameliorate the MetS.</p> <p>Results</p> <p>In this study, daily oral administration of 50 mg/kg of GA for one week led to significant increase in LPL expression in the quadriceps femoris (<it>p </it>< 0.05) but non-significant increase in the abdominal muscle, kidney, liver, heart and the subcutaneous and visceral adipose tissues (<it>p </it>> 0.05) of the GA-treated rats compared to the control. Decrease in adipocyte size (<it>p </it>> 0.05) in both the visceral and subcutaneous adipose tissue depots accompanies such selective induction of LPL expression. Consistent improvement in serum lipid parameters was also observed, with decrease in serum free fatty acid, triacylglycerol, total cholesterol and LDL-cholesterol but elevated HDL-cholesterol (<it>p </it>> 0.05). Histological analysis using tissue lipid staining with Oil Red O showed significant decrease in lipid deposition in the abdominal muscle and quadriceps femoris (<it>p </it>< 0.05) but non-significant decrease in the heart, kidney and liver (<it>p </it>> 0.05).</p> <p>Conclusion</p> <p>Results from this study may imply that GA could counteract the development of visceral obesity and improve dyslipidaemia via selective induction of tissue LPL expression and a positive shift in serum lipid parameters respectively, and retard the development of IR associated with tissue steatosis.</p>http://www.lipidworld.com/content/8/1/31 |
| spellingShingle | Ton So Kadir Khalid Liong Shih Chia Yoke Lim Wai Syed Husain Sharifah Lipoprotein lipase expression, serum lipid and tissue lipid deposition in orally-administered glycyrrhizic acid-treated rats Lipids in Health and Disease |
| title | Lipoprotein lipase expression, serum lipid and tissue lipid deposition in orally-administered glycyrrhizic acid-treated rats |
| title_full | Lipoprotein lipase expression, serum lipid and tissue lipid deposition in orally-administered glycyrrhizic acid-treated rats |
| title_fullStr | Lipoprotein lipase expression, serum lipid and tissue lipid deposition in orally-administered glycyrrhizic acid-treated rats |
| title_full_unstemmed | Lipoprotein lipase expression, serum lipid and tissue lipid deposition in orally-administered glycyrrhizic acid-treated rats |
| title_short | Lipoprotein lipase expression, serum lipid and tissue lipid deposition in orally-administered glycyrrhizic acid-treated rats |
| title_sort | lipoprotein lipase expression serum lipid and tissue lipid deposition in orally administered glycyrrhizic acid treated rats |
| url | http://www.lipidworld.com/content/8/1/31 |
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