Hidden synaptic differences in a neural circuit underlie differential behavioral susceptibility to a neural injury
Individuals vary in their responses to stroke and trauma, hampering predictions of outcomes. One reason might be that neural circuits contain hidden variability that becomes relevant only when those individuals are challenged by injury. We found that in the mollusc, Tritonia diomedea, subtle differe...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2014-06-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/02598 |
| _version_ | 1828107665779195904 |
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| author | Akira Sakurai Arianna N Tamvacakis Paul S Katz |
| author_facet | Akira Sakurai Arianna N Tamvacakis Paul S Katz |
| author_sort | Akira Sakurai |
| collection | DOAJ |
| description | Individuals vary in their responses to stroke and trauma, hampering predictions of outcomes. One reason might be that neural circuits contain hidden variability that becomes relevant only when those individuals are challenged by injury. We found that in the mollusc, Tritonia diomedea, subtle differences between animals within the neural circuit underlying swimming behavior had no behavioral relevance under normal conditions but caused differential vulnerability of the behavior to a particular brain lesion. The extent of motor impairment correlated with the site of spike initiation in a specific neuron in the neural circuit, which was determined by the strength of an inhibitory synapse onto this neuron. Artificially increasing or decreasing this inhibitory synaptic conductance with dynamic clamp correspondingly altered the extent of motor impairment by the lesion without affecting normal operation. The results suggest that neural circuit differences could serve as hidden phenotypes for predicting the behavioral outcome of neural damage. |
| first_indexed | 2024-04-11T10:34:43Z |
| format | Article |
| id | doaj.art-876dcf1da9d146da9926ec4b7937dd8e |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T10:34:43Z |
| publishDate | 2014-06-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-876dcf1da9d146da9926ec4b7937dd8e2022-12-22T04:29:20ZengeLife Sciences Publications LtdeLife2050-084X2014-06-01310.7554/eLife.02598Hidden synaptic differences in a neural circuit underlie differential behavioral susceptibility to a neural injuryAkira Sakurai0https://orcid.org/0000-0003-2858-1620Arianna N Tamvacakis1Paul S Katz2Neuroscience Institute, Georgia State University, Atlanta, United StatesNeuroscience Institute, Georgia State University, Atlanta, United StatesNeuroscience Institute, Georgia State University, Atlanta, United StatesIndividuals vary in their responses to stroke and trauma, hampering predictions of outcomes. One reason might be that neural circuits contain hidden variability that becomes relevant only when those individuals are challenged by injury. We found that in the mollusc, Tritonia diomedea, subtle differences between animals within the neural circuit underlying swimming behavior had no behavioral relevance under normal conditions but caused differential vulnerability of the behavior to a particular brain lesion. The extent of motor impairment correlated with the site of spike initiation in a specific neuron in the neural circuit, which was determined by the strength of an inhibitory synapse onto this neuron. Artificially increasing or decreasing this inhibitory synaptic conductance with dynamic clamp correspondingly altered the extent of motor impairment by the lesion without affecting normal operation. The results suggest that neural circuit differences could serve as hidden phenotypes for predicting the behavioral outcome of neural damage.https://elifesciences.org/articles/02598Tritonia diomedeaindividual variabilitysynapseneural injurycentral pattern generatordynamic clamp |
| spellingShingle | Akira Sakurai Arianna N Tamvacakis Paul S Katz Hidden synaptic differences in a neural circuit underlie differential behavioral susceptibility to a neural injury eLife Tritonia diomedea individual variability synapse neural injury central pattern generator dynamic clamp |
| title | Hidden synaptic differences in a neural circuit underlie differential behavioral susceptibility to a neural injury |
| title_full | Hidden synaptic differences in a neural circuit underlie differential behavioral susceptibility to a neural injury |
| title_fullStr | Hidden synaptic differences in a neural circuit underlie differential behavioral susceptibility to a neural injury |
| title_full_unstemmed | Hidden synaptic differences in a neural circuit underlie differential behavioral susceptibility to a neural injury |
| title_short | Hidden synaptic differences in a neural circuit underlie differential behavioral susceptibility to a neural injury |
| title_sort | hidden synaptic differences in a neural circuit underlie differential behavioral susceptibility to a neural injury |
| topic | Tritonia diomedea individual variability synapse neural injury central pattern generator dynamic clamp |
| url | https://elifesciences.org/articles/02598 |
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