Secretory pathways and multiple functions of nonstructural protein 1 in flavivirus infection
The genus Flavivirus contains a wide variety of viruses that cause severe disease in humans, including dengue virus, yellow fever virus, Zika virus, West Nile virus, Japanese encephalitis virus and tick-borne encephalitis virus. Nonstructural protein 1 (NS1) is a glycoprotein that encodes a 352-amin...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1205002/full |
| _version_ | 1797781720401969152 |
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| author | Senzhao Zhang Senzhao Zhang Senzhao Zhang Yu He Yu He Yu He Zhen Wu Zhen Wu Zhen Wu Mingshu Wang Mingshu Wang Mingshu Wang Renyong Jia Renyong Jia Renyong Jia Dekang Zhu Dekang Zhu Dekang Zhu Mafeng Liu Mafeng Liu Mafeng Liu Xinxin Zhao Xinxin Zhao Xinxin Zhao Qiao Yang Qiao Yang Qiao Yang Ying Wu Ying Wu Ying Wu Shaqiu Zhang Shaqiu Zhang Shaqiu Zhang Juan Huang Juan Huang Juan Huang Xumin Ou Xumin Ou Xumin Ou Qun Gao Qun Gao Qun Gao Di Sun Di Sun Di Sun Ling Zhang Yanling Yu Shun Chen Shun Chen Shun Chen Anchun Cheng Anchun Cheng Anchun Cheng |
| author_facet | Senzhao Zhang Senzhao Zhang Senzhao Zhang Yu He Yu He Yu He Zhen Wu Zhen Wu Zhen Wu Mingshu Wang Mingshu Wang Mingshu Wang Renyong Jia Renyong Jia Renyong Jia Dekang Zhu Dekang Zhu Dekang Zhu Mafeng Liu Mafeng Liu Mafeng Liu Xinxin Zhao Xinxin Zhao Xinxin Zhao Qiao Yang Qiao Yang Qiao Yang Ying Wu Ying Wu Ying Wu Shaqiu Zhang Shaqiu Zhang Shaqiu Zhang Juan Huang Juan Huang Juan Huang Xumin Ou Xumin Ou Xumin Ou Qun Gao Qun Gao Qun Gao Di Sun Di Sun Di Sun Ling Zhang Yanling Yu Shun Chen Shun Chen Shun Chen Anchun Cheng Anchun Cheng Anchun Cheng |
| author_sort | Senzhao Zhang |
| collection | DOAJ |
| description | The genus Flavivirus contains a wide variety of viruses that cause severe disease in humans, including dengue virus, yellow fever virus, Zika virus, West Nile virus, Japanese encephalitis virus and tick-borne encephalitis virus. Nonstructural protein 1 (NS1) is a glycoprotein that encodes a 352-amino-acid polypeptide and has a molecular weight of 46–55 kDa depending on its glycosylation status. NS1 is highly conserved among multiple flaviviruses and occurs in distinct forms, including a dimeric form within the endoplasmic reticulum, a cell-associated form on the plasma membrane, or a secreted hexameric form (sNS1) trafficked to the extracellular matrix. Intracellular dimeric NS1 interacts with other NSs to participate in viral replication and virion maturation, while extracellular sNS1 plays a critical role in immune evasion, flavivirus pathogenesis and interactions with natural vectors. In this review, we provide an overview of recent research progress on flavivirus NS1, including research on the structural details, the secretory pathways in mammalian and mosquito cells and the multiple functions in viral replication, immune evasion, pathogenesis and interaction with natural hosts, drawing together the previous data to determine the properties of this protein. |
| first_indexed | 2024-03-13T00:01:04Z |
| format | Article |
| id | doaj.art-876f1dd8e4f4420da138c3b7fb8ca806 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-13T00:01:04Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-876f1dd8e4f4420da138c3b7fb8ca8062023-07-13T10:18:25ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-07-011410.3389/fimmu.2023.12050021205002Secretory pathways and multiple functions of nonstructural protein 1 in flavivirus infectionSenzhao Zhang0Senzhao Zhang1Senzhao Zhang2Yu He3Yu He4Yu He5Zhen Wu6Zhen Wu7Zhen Wu8Mingshu Wang9Mingshu Wang10Mingshu Wang11Renyong Jia12Renyong Jia13Renyong Jia14Dekang Zhu15Dekang Zhu16Dekang Zhu17Mafeng Liu18Mafeng Liu19Mafeng Liu20Xinxin Zhao21Xinxin Zhao22Xinxin Zhao23Qiao Yang24Qiao Yang25Qiao Yang26Ying Wu27Ying Wu28Ying Wu29Shaqiu Zhang30Shaqiu Zhang31Shaqiu Zhang32Juan Huang33Juan Huang34Juan Huang35Xumin Ou36Xumin Ou37Xumin Ou38Qun Gao39Qun Gao40Qun Gao41Di Sun42Di Sun43Di Sun44Ling Zhang45Yanling Yu46Shun Chen47Shun Chen48Shun Chen49Anchun Cheng50Anchun Cheng51Anchun Cheng52Research Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People’s Republic of China, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People’s Republic of China, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People’s Republic of China, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People’s Republic of China, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People’s Republic of China, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People’s Republic of China, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People’s Republic of China, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People’s Republic of China, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People’s Republic of China, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People’s Republic of China, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People’s Republic of China, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People’s Republic of China, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People’s Republic of China, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People’s Republic of China, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People’s Republic of China, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People’s Republic of China, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People’s Republic of China, Chengdu, ChinaThe genus Flavivirus contains a wide variety of viruses that cause severe disease in humans, including dengue virus, yellow fever virus, Zika virus, West Nile virus, Japanese encephalitis virus and tick-borne encephalitis virus. Nonstructural protein 1 (NS1) is a glycoprotein that encodes a 352-amino-acid polypeptide and has a molecular weight of 46–55 kDa depending on its glycosylation status. NS1 is highly conserved among multiple flaviviruses and occurs in distinct forms, including a dimeric form within the endoplasmic reticulum, a cell-associated form on the plasma membrane, or a secreted hexameric form (sNS1) trafficked to the extracellular matrix. Intracellular dimeric NS1 interacts with other NSs to participate in viral replication and virion maturation, while extracellular sNS1 plays a critical role in immune evasion, flavivirus pathogenesis and interactions with natural vectors. In this review, we provide an overview of recent research progress on flavivirus NS1, including research on the structural details, the secretory pathways in mammalian and mosquito cells and the multiple functions in viral replication, immune evasion, pathogenesis and interaction with natural hosts, drawing together the previous data to determine the properties of this protein.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1205002/fullflavivirusnonstructural protein 1structuresecretory pathwaysimmune evasionpathogenesis |
| spellingShingle | Senzhao Zhang Senzhao Zhang Senzhao Zhang Yu He Yu He Yu He Zhen Wu Zhen Wu Zhen Wu Mingshu Wang Mingshu Wang Mingshu Wang Renyong Jia Renyong Jia Renyong Jia Dekang Zhu Dekang Zhu Dekang Zhu Mafeng Liu Mafeng Liu Mafeng Liu Xinxin Zhao Xinxin Zhao Xinxin Zhao Qiao Yang Qiao Yang Qiao Yang Ying Wu Ying Wu Ying Wu Shaqiu Zhang Shaqiu Zhang Shaqiu Zhang Juan Huang Juan Huang Juan Huang Xumin Ou Xumin Ou Xumin Ou Qun Gao Qun Gao Qun Gao Di Sun Di Sun Di Sun Ling Zhang Yanling Yu Shun Chen Shun Chen Shun Chen Anchun Cheng Anchun Cheng Anchun Cheng Secretory pathways and multiple functions of nonstructural protein 1 in flavivirus infection Frontiers in Immunology flavivirus nonstructural protein 1 structure secretory pathways immune evasion pathogenesis |
| title | Secretory pathways and multiple functions of nonstructural protein 1 in flavivirus infection |
| title_full | Secretory pathways and multiple functions of nonstructural protein 1 in flavivirus infection |
| title_fullStr | Secretory pathways and multiple functions of nonstructural protein 1 in flavivirus infection |
| title_full_unstemmed | Secretory pathways and multiple functions of nonstructural protein 1 in flavivirus infection |
| title_short | Secretory pathways and multiple functions of nonstructural protein 1 in flavivirus infection |
| title_sort | secretory pathways and multiple functions of nonstructural protein 1 in flavivirus infection |
| topic | flavivirus nonstructural protein 1 structure secretory pathways immune evasion pathogenesis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1205002/full |
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