Deciphering antifungal and antibiofilm mechanisms of isobavachalcone against Cryptococcus neoformans through RNA-seq and functional analyses

Deciphering antifungal and antibiofilm mechanisms of isobavachalcone against Cryptococcus neoformans through RNA-seq and functional analyses

Abstract Cryptococcus neoformans has been designated as critical fungal pathogens by the World Health Organization, mainly due to limited treatment options and the prevalence of antifungal resistance. Consequently, the utilization of novel antifungal agents is crucial for the effective treatment of...

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Bibliographic Details
Main Authors: Weidong Qian, Jiaxing Lu, Chang Gao, Qiming Liu, Yongdong Li, Qiao Zeng, Jian Zhang, Ting Wang, Si Chen
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Microbial Cell Factories
Subjects:
Cryptococcus neoformans
Isobavachalcone
Antifungal activity
RNA-sequencing
Functional profiling
Online Access:https://doi.org/10.1186/s12934-024-02369-2

Internet

https://doi.org/10.1186/s12934-024-02369-2

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