T cell cascade regulation initiates systemic antitumor immunity through living drug factory of anti-PD-1/IL-12 engineered probiotics
Summary: Immune checkpoint blockade (ICB) has revolutionized cancer therapy but only works in a subset of patients due to the insufficient infiltration, persistent exhaustion, and inactivation of T cells within a tumor. Herein, we develop an engineered probiotic (interleukin [IL]-12 nanoparticle Esc...
Main Authors: | Jianhong Liao, Hong Pan, Guojun Huang, Han Gong, Ze Chen, Ting Yin, Baozhen Zhang, Tingtao Chen, Mingbin Zheng, Lintao Cai |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2024-04-01
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Series: | Cell Reports |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124724004145 |
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