Trends in utilization and costs of migraine medications, 2017–2020
Abstract Objective This study examines changes in utilization and costs trends associated with migraine medications. Background Migraine attacks are a burden to many patients. There are many pharmacotherapy options available with newer migraine drug classes entering the market in the past decade. Li...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | The Journal of Headache and Pain |
| Online Access: | https://doi.org/10.1186/s10194-022-01476-y |
| _version_ | 1811188731255717888 |
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| author | Jennifer L. Nguyen Kiraat Munshi Samuel K. Peasah Elizabeth C. S. Swart Monal Kohli Rochelle Henderson Chester B. Good |
| author_facet | Jennifer L. Nguyen Kiraat Munshi Samuel K. Peasah Elizabeth C. S. Swart Monal Kohli Rochelle Henderson Chester B. Good |
| author_sort | Jennifer L. Nguyen |
| collection | DOAJ |
| description | Abstract Objective This study examines changes in utilization and costs trends associated with migraine medications. Background Migraine attacks are a burden to many patients. There are many pharmacotherapy options available with newer migraine drug classes entering the market in the past decade. Little is known about the use, associated costs, and the impact of the newer agents. Methods This retrospective, cross-sectional study examined 2017–2020 administrative claims from a large national pharmacy benefits manager. Patients aged ≥ 18 years enrolled in commercial, Medicare, Medicaid, or health insurance exchange insurance plans who filled ≥ 2 prescription claims for triptans, ergotamines, isometheptenes, gepants, ditans, and CGRP mABs were included. A two-sample t-test was conducted to estimate whether differences in mean utilization and costs between 2017 and 2020 were statistically significant for migraine drug classes, except for CGRP mABs, which were estimated between 2018 and 2020. Results The sample ranged from 161,369 (2017) to 240,330 (2020) patients. 84.5% (n = 203,110; 2020) of patients were women. The number of 30-day adjusted prescription fills for prophylaxis remained stable over the four-year period, except for CGRP mABs, which increased from 0.5% (n = 0.007; 2018) to 5.3% (n = 0.075; 2020). Antiepileptics, antidepressants and beta blockers were the most common prophylaxes, while triptans, non-steroidal anti-inflammatory drugs/non-narcotic analgesics and opioids were the most common treatments utilized. CGRP mABs were the most expensive, while utilization of triptans were the highest. CGRP mABs had the largest increase in utilization (177.5%) and costs (166.3%) PPPM in 2020 ($291.17) compared to 2018 ($109.35), the year they were first available (p < 0.001). Between 2018 and 2020, costs increased overall and for commercial and Medicare enrollees, but remained unchanged for Medicaid and HIX members. Conclusion Our study demonstrates a shift in migraine medication utilization from 2017–2020, where increased use of CGRP mABs had a significant contribution to increased costs. These increased pharmacy costs must be weighed against the improved tolerability of these agents likely resulting in other healthcare and indirect cost savings. |
| first_indexed | 2024-04-11T14:24:38Z |
| format | Article |
| id | doaj.art-87713e6cdce944219602ac8a7fa73067 |
| institution | Directory Open Access Journal |
| issn | 1129-2369 1129-2377 |
| language | English |
| last_indexed | 2024-04-11T14:24:38Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | The Journal of Headache and Pain |
| spelling | doaj.art-87713e6cdce944219602ac8a7fa730672022-12-22T04:18:56ZengBMCThe Journal of Headache and Pain1129-23691129-23772022-08-012311910.1186/s10194-022-01476-yTrends in utilization and costs of migraine medications, 2017–2020Jennifer L. Nguyen0Kiraat Munshi1Samuel K. Peasah2Elizabeth C. S. Swart3Monal Kohli4Rochelle Henderson5Chester B. Good6Centers for High-Value Health Care and Value-Based Pharmacy Initiatives, UPMC Health PlanEvernorth Research InstituteCenters for High-Value Health Care and Value-Based Pharmacy Initiatives, UPMC Health PlanCenters for High-Value Health Care and Value-Based Pharmacy Initiatives, UPMC Health PlanEvernorth Research InstituteEvernorth Research InstituteCenters for High-Value Health Care and Value-Based Pharmacy Initiatives, UPMC Health PlanAbstract Objective This study examines changes in utilization and costs trends associated with migraine medications. Background Migraine attacks are a burden to many patients. There are many pharmacotherapy options available with newer migraine drug classes entering the market in the past decade. Little is known about the use, associated costs, and the impact of the newer agents. Methods This retrospective, cross-sectional study examined 2017–2020 administrative claims from a large national pharmacy benefits manager. Patients aged ≥ 18 years enrolled in commercial, Medicare, Medicaid, or health insurance exchange insurance plans who filled ≥ 2 prescription claims for triptans, ergotamines, isometheptenes, gepants, ditans, and CGRP mABs were included. A two-sample t-test was conducted to estimate whether differences in mean utilization and costs between 2017 and 2020 were statistically significant for migraine drug classes, except for CGRP mABs, which were estimated between 2018 and 2020. Results The sample ranged from 161,369 (2017) to 240,330 (2020) patients. 84.5% (n = 203,110; 2020) of patients were women. The number of 30-day adjusted prescription fills for prophylaxis remained stable over the four-year period, except for CGRP mABs, which increased from 0.5% (n = 0.007; 2018) to 5.3% (n = 0.075; 2020). Antiepileptics, antidepressants and beta blockers were the most common prophylaxes, while triptans, non-steroidal anti-inflammatory drugs/non-narcotic analgesics and opioids were the most common treatments utilized. CGRP mABs were the most expensive, while utilization of triptans were the highest. CGRP mABs had the largest increase in utilization (177.5%) and costs (166.3%) PPPM in 2020 ($291.17) compared to 2018 ($109.35), the year they were first available (p < 0.001). Between 2018 and 2020, costs increased overall and for commercial and Medicare enrollees, but remained unchanged for Medicaid and HIX members. Conclusion Our study demonstrates a shift in migraine medication utilization from 2017–2020, where increased use of CGRP mABs had a significant contribution to increased costs. These increased pharmacy costs must be weighed against the improved tolerability of these agents likely resulting in other healthcare and indirect cost savings.https://doi.org/10.1186/s10194-022-01476-y |
| spellingShingle | Jennifer L. Nguyen Kiraat Munshi Samuel K. Peasah Elizabeth C. S. Swart Monal Kohli Rochelle Henderson Chester B. Good Trends in utilization and costs of migraine medications, 2017–2020 The Journal of Headache and Pain |
| title | Trends in utilization and costs of migraine medications, 2017–2020 |
| title_full | Trends in utilization and costs of migraine medications, 2017–2020 |
| title_fullStr | Trends in utilization and costs of migraine medications, 2017–2020 |
| title_full_unstemmed | Trends in utilization and costs of migraine medications, 2017–2020 |
| title_short | Trends in utilization and costs of migraine medications, 2017–2020 |
| title_sort | trends in utilization and costs of migraine medications 2017 2020 |
| url | https://doi.org/10.1186/s10194-022-01476-y |
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