Quantification of epicardial fat with cardiac CT angiography and association with cardiovascular risk factors in symptomatic patients: from the ALTER-BIO (Alternative Cardiovascular Bio-Imaging markers) registry
PURPOSE:We aimed to assess the association between features of epicardial adipose tissue and demographic, morphometric and clinical data, in a large population of symptomatic patients with clinical indication to cardiac computed tomography (CT) angiography.METHODS:Epicardial fat volume (EFV) and adi...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2019-01-01
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| Series: | Diagnostic and Interventional Radiology |
| Online Access: |
http://www.dirjournal.org/archives/archive-detail/article-preview/quantification-of-epicardial-fat-with-cardiac-ct-a/54993
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| _version_ | 1797691288645009408 |
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| author | Gianluca Milanese Mario Silva Livia Bruno Matteo Goldoni Giorgio Benedetti Enrica Rossi Caterina Ferrari Ludovico La Grutta Erica Maffei Patrizia Toia Ernesto Forte Riccardo C Bonadonna Nicola Sverzellati Filippo Cademartiri |
| author_facet | Gianluca Milanese Mario Silva Livia Bruno Matteo Goldoni Giorgio Benedetti Enrica Rossi Caterina Ferrari Ludovico La Grutta Erica Maffei Patrizia Toia Ernesto Forte Riccardo C Bonadonna Nicola Sverzellati Filippo Cademartiri |
| author_sort | Gianluca Milanese |
| collection | DOAJ |
| description | PURPOSE:We aimed to assess the association between features of epicardial adipose tissue and demographic, morphometric and clinical data, in a large population of symptomatic patients with clinical indication to cardiac computed tomography (CT) angiography.METHODS:Epicardial fat volume (EFV) and adipose CT density of 1379 patients undergoing cardiac CT angiography (918 men, 66.6%; age range, 18–93 years; median age, 64 years) were semi-automatically quantified. Clinical variables were compared between diabetic and nondiabetic patients to assess potential differences in EFV and adipose CT density. Multiple regression models were calculated to find the clinical variables with a significant association with EFV and adipose CT density.RESULTS:The median EFV in diabetic patients (112.87 mL) was higher compared with nondiabetic patients (82.62 mL; P < 0.001). The explanatory model of the multivariable analysis showed the strongest associations between EFV and BMI (β=0.442) and age (β=0.365). Significant yet minor association was found with sex (β=0.203), arterial hypertension (β=0.072), active smoking (β=0.068), diabetes (β=0.068), hypercholesterolemia (β=0.046) and cardiac height (β=0.118). The mean density of epicardial adipose tissue was associated with BMI (β=0.384), age (β=0.105), smoking (β=0.088), and diabetes (β=0.085).CONCLUSION:In a large population of symptomatic patients, EFV is higher in diabetic patients compared with nondiabetic patients. Clinical variables are associated with quantitative features of epicardial fat. |
| first_indexed | 2024-03-12T02:11:18Z |
| format | Article |
| id | doaj.art-8771d870c5a140fd8af778b703af9f7a |
| institution | Directory Open Access Journal |
| issn | 1305-3825 1305-3612 |
| language | English |
| last_indexed | 2024-03-12T02:11:18Z |
| publishDate | 2019-01-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Diagnostic and Interventional Radiology |
| spelling | doaj.art-8771d870c5a140fd8af778b703af9f7a2023-09-06T13:05:11ZengGalenos Publishing HouseDiagnostic and Interventional Radiology1305-38251305-36122019-01-01251354110.5152/dir.2018.1803713049054Quantification of epicardial fat with cardiac CT angiography and association with cardiovascular risk factors in symptomatic patients: from the ALTER-BIO (Alternative Cardiovascular Bio-Imaging markers) registryGianluca Milanese0Mario Silva1Livia Bruno2Matteo Goldoni3Giorgio Benedetti4Enrica Rossi5Caterina Ferrari6Ludovico La Grutta7Erica Maffei8Patrizia Toia9Ernesto Forte10Riccardo C Bonadonna11Nicola Sverzellati12Filippo Cademartiri13 Division of Radiology, University of Parma, Parma, Italy; Department of Medicine and Surgery, University of Parma, Parma, Italy Division of Radiology, University of Parma, Parma, Italy; Department of Medicine and Surgery, University of Parma, Parma, Italy Department of Radiology, University of Palermo, Palermo, Italy Department of Medicine and Surgery, University of Parma, Parma, Italy Division of Radiology, University of Parma, Parma, Italy; Department of Medicine and Surgery, University of Parma, Parma, Italy Division of Radiology, University of Parma, Parma, Italy; Department of Radiology, Area Vasta 1/ASUR Marche, Urbino, Italy Division of Radiology, University of Parma, Parma, Italy; Department of Medicine and Surgery, University of Parma, Parma, Italy Department of Radiology, University of Palermo, Palermo, Italy Department of Radiology, Area Vasta 1/ASUR Marche, Urbino, Italy Department of Radiology, University of Palermo, Palermo, Italy Cardiovascular Imaging Center, SDN IRCCS, Naples, Italy Division of Endocrinology and Metabolic Diseases, Department of Medicine and Surgery, University of Parma, Parma, Italy Division of Radiology, University of Parma, Parma, Italy; Department of Medicine and Surgery, University of Parma, Parma, Italy Cardiovascular Imaging Center SDN IRCCS, Naples, Italy PURPOSE:We aimed to assess the association between features of epicardial adipose tissue and demographic, morphometric and clinical data, in a large population of symptomatic patients with clinical indication to cardiac computed tomography (CT) angiography.METHODS:Epicardial fat volume (EFV) and adipose CT density of 1379 patients undergoing cardiac CT angiography (918 men, 66.6%; age range, 18–93 years; median age, 64 years) were semi-automatically quantified. Clinical variables were compared between diabetic and nondiabetic patients to assess potential differences in EFV and adipose CT density. Multiple regression models were calculated to find the clinical variables with a significant association with EFV and adipose CT density.RESULTS:The median EFV in diabetic patients (112.87 mL) was higher compared with nondiabetic patients (82.62 mL; P < 0.001). The explanatory model of the multivariable analysis showed the strongest associations between EFV and BMI (β=0.442) and age (β=0.365). Significant yet minor association was found with sex (β=0.203), arterial hypertension (β=0.072), active smoking (β=0.068), diabetes (β=0.068), hypercholesterolemia (β=0.046) and cardiac height (β=0.118). The mean density of epicardial adipose tissue was associated with BMI (β=0.384), age (β=0.105), smoking (β=0.088), and diabetes (β=0.085).CONCLUSION:In a large population of symptomatic patients, EFV is higher in diabetic patients compared with nondiabetic patients. Clinical variables are associated with quantitative features of epicardial fat. http://www.dirjournal.org/archives/archive-detail/article-preview/quantification-of-epicardial-fat-with-cardiac-ct-a/54993 |
| spellingShingle | Gianluca Milanese Mario Silva Livia Bruno Matteo Goldoni Giorgio Benedetti Enrica Rossi Caterina Ferrari Ludovico La Grutta Erica Maffei Patrizia Toia Ernesto Forte Riccardo C Bonadonna Nicola Sverzellati Filippo Cademartiri Quantification of epicardial fat with cardiac CT angiography and association with cardiovascular risk factors in symptomatic patients: from the ALTER-BIO (Alternative Cardiovascular Bio-Imaging markers) registry Diagnostic and Interventional Radiology |
| title | Quantification of epicardial fat with cardiac CT angiography and association with cardiovascular risk factors in symptomatic patients: from the ALTER-BIO (Alternative Cardiovascular Bio-Imaging markers) registry |
| title_full | Quantification of epicardial fat with cardiac CT angiography and association with cardiovascular risk factors in symptomatic patients: from the ALTER-BIO (Alternative Cardiovascular Bio-Imaging markers) registry |
| title_fullStr | Quantification of epicardial fat with cardiac CT angiography and association with cardiovascular risk factors in symptomatic patients: from the ALTER-BIO (Alternative Cardiovascular Bio-Imaging markers) registry |
| title_full_unstemmed | Quantification of epicardial fat with cardiac CT angiography and association with cardiovascular risk factors in symptomatic patients: from the ALTER-BIO (Alternative Cardiovascular Bio-Imaging markers) registry |
| title_short | Quantification of epicardial fat with cardiac CT angiography and association with cardiovascular risk factors in symptomatic patients: from the ALTER-BIO (Alternative Cardiovascular Bio-Imaging markers) registry |
| title_sort | quantification of epicardial fat with cardiac ct angiography and association with cardiovascular risk factors in symptomatic patients from the alter bio alternative cardiovascular bio imaging markers registry |
| url |
http://www.dirjournal.org/archives/archive-detail/article-preview/quantification-of-epicardial-fat-with-cardiac-ct-a/54993
|
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