Characterization and Antimicrobial Susceptibility of Pathogens Associated with Periodontal Abscess
Knowledge of microbial composition and antimicrobials’ susceptibility to periodontal abscesses is vital for their successful treatment. The current study aims to provide a thorough overview of the clinical and microbial features of periodontal abscesses of the local community. The study was carried...
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| Format: | Article |
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MDPI AG
2020-09-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/9/10/654 |
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| author | Muhammad Irshad Mohammad Khursheed Alam Ahmad Alawneh Mohammed Abdullah Alhadi Ahmed Abdullah Alhadi Yasser Saleh Almunajem Fesal Farag Alanezi Sharafi Abdullah Al Sagoor Abdulrahman Mudaysh Bajawi Ahmed Ali Alfawzan Mohammad Amjad Kamal |
| author_facet | Muhammad Irshad Mohammad Khursheed Alam Ahmad Alawneh Mohammed Abdullah Alhadi Ahmed Abdullah Alhadi Yasser Saleh Almunajem Fesal Farag Alanezi Sharafi Abdullah Al Sagoor Abdulrahman Mudaysh Bajawi Ahmed Ali Alfawzan Mohammad Amjad Kamal |
| author_sort | Muhammad Irshad |
| collection | DOAJ |
| description | Knowledge of microbial composition and antimicrobials’ susceptibility to periodontal abscesses is vital for their successful treatment. The current study aims to provide a thorough overview of the clinical and microbial features of periodontal abscesses of the local community. The study was carried out at Rehman College of Dentistry, Peshawar, Pakistan between December 2019 to March 2020. Clinical measurements and microbial samples were collected from 45 subjects. Microbial samples were anaerobically cultured for the growth of selected bacterial species. E-test was used to assess the susceptibility of bacterial species grown from the patient samples to amoxicillin, azithromycin, metronidazole, and tetracycline. The majority of affected patients had preexisting chronic periodontitis. All abscesses clinically demonstrated bleeding on probing and suppuration. The periodontal abscess was most commonly associated with lower incisors and canines, followed by lower molars and then upper incisor and canine teeth. <i>Fusobacterium</i> spp. (73%) was the most frequently detected species followed by <i>Prevotella intermedia/nigrescens</i> (65%), <i>Porphyromonas gingivalis</i> (46%) and <i>Aggregatibacter actinomycetemcomitans</i> (24%). The detected clinical isolates of certain bacteria demonstrated resistance to all tested antibiotics except azithromycin. We conclude that <i>Fusobacterium</i> spp., <i>P. intermedia/nigrescens</i>, <i>P. gingivalis, C. rectus, T. forsythia</i> and <i>A. actinomycetemcomitans</i> are closely associated with periodontal abscess. Bacterial species associated with periodontal abscess demonstrated some level of antimicrobial resistance to amoxicillin, metronidazole and tetracycline while antibiotic resistance to azithromycin could not be demonstrated. |
| first_indexed | 2024-03-10T15:57:56Z |
| format | Article |
| id | doaj.art-877235d8f99c4917949f3a41a16a84c8 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T15:57:56Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-877235d8f99c4917949f3a41a16a84c82023-11-20T15:32:16ZengMDPI AGAntibiotics2079-63822020-09-0191065410.3390/antibiotics9100654Characterization and Antimicrobial Susceptibility of Pathogens Associated with Periodontal AbscessMuhammad Irshad0Mohammad Khursheed Alam1Ahmad Alawneh2Mohammed Abdullah Alhadi3Ahmed Abdullah Alhadi4Yasser Saleh Almunajem5Fesal Farag Alanezi6Sharafi Abdullah Al Sagoor7Abdulrahman Mudaysh Bajawi8Ahmed Ali Alfawzan9Mohammad Amjad Kamal10Department of Oral Pathology, Rehman College of Dentistry, RMI, Hayatabad Phase V, Peshawar, KP, Peshawar 25000, PakistanCollege of Dentistry, Jouf University, Sakaka 72345, Saudi ArabiaDental Department, Jordanian Royal Medical Services, Amman 11180, JordanAljouf Specialist Dental Center, MOH, Sakaka 72345, Saudi ArabiaMinistry of Health in Saudi Arabia, Riyadh 11176, JurisdictionMinistry of Health in Saudi Arabia, Riyadh 11176, JurisdictionMinistry of Health in Saudi Arabia, Riyadh 11176, JurisdictionMinistry of Health in Saudi Arabia, Riyadh 11176, JurisdictionMinistry of Health in Saudi Arabia, Riyadh 11176, JurisdictionDepartment of Preventive Dentistry, College of Dentistry in Ar Rass, Qassim University, Ar Rass 51921, Saudi ArabiaKing Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi ArabiaKnowledge of microbial composition and antimicrobials’ susceptibility to periodontal abscesses is vital for their successful treatment. The current study aims to provide a thorough overview of the clinical and microbial features of periodontal abscesses of the local community. The study was carried out at Rehman College of Dentistry, Peshawar, Pakistan between December 2019 to March 2020. Clinical measurements and microbial samples were collected from 45 subjects. Microbial samples were anaerobically cultured for the growth of selected bacterial species. E-test was used to assess the susceptibility of bacterial species grown from the patient samples to amoxicillin, azithromycin, metronidazole, and tetracycline. The majority of affected patients had preexisting chronic periodontitis. All abscesses clinically demonstrated bleeding on probing and suppuration. The periodontal abscess was most commonly associated with lower incisors and canines, followed by lower molars and then upper incisor and canine teeth. <i>Fusobacterium</i> spp. (73%) was the most frequently detected species followed by <i>Prevotella intermedia/nigrescens</i> (65%), <i>Porphyromonas gingivalis</i> (46%) and <i>Aggregatibacter actinomycetemcomitans</i> (24%). The detected clinical isolates of certain bacteria demonstrated resistance to all tested antibiotics except azithromycin. We conclude that <i>Fusobacterium</i> spp., <i>P. intermedia/nigrescens</i>, <i>P. gingivalis, C. rectus, T. forsythia</i> and <i>A. actinomycetemcomitans</i> are closely associated with periodontal abscess. Bacterial species associated with periodontal abscess demonstrated some level of antimicrobial resistance to amoxicillin, metronidazole and tetracycline while antibiotic resistance to azithromycin could not be demonstrated.https://www.mdpi.com/2079-6382/9/10/654periodontitisantimicrobial resistanceperiodontal abscessamoxycillinmetronidazoletetracycline |
| spellingShingle | Muhammad Irshad Mohammad Khursheed Alam Ahmad Alawneh Mohammed Abdullah Alhadi Ahmed Abdullah Alhadi Yasser Saleh Almunajem Fesal Farag Alanezi Sharafi Abdullah Al Sagoor Abdulrahman Mudaysh Bajawi Ahmed Ali Alfawzan Mohammad Amjad Kamal Characterization and Antimicrobial Susceptibility of Pathogens Associated with Periodontal Abscess Antibiotics periodontitis antimicrobial resistance periodontal abscess amoxycillin metronidazole tetracycline |
| title | Characterization and Antimicrobial Susceptibility of Pathogens Associated with Periodontal Abscess |
| title_full | Characterization and Antimicrobial Susceptibility of Pathogens Associated with Periodontal Abscess |
| title_fullStr | Characterization and Antimicrobial Susceptibility of Pathogens Associated with Periodontal Abscess |
| title_full_unstemmed | Characterization and Antimicrobial Susceptibility of Pathogens Associated with Periodontal Abscess |
| title_short | Characterization and Antimicrobial Susceptibility of Pathogens Associated with Periodontal Abscess |
| title_sort | characterization and antimicrobial susceptibility of pathogens associated with periodontal abscess |
| topic | periodontitis antimicrobial resistance periodontal abscess amoxycillin metronidazole tetracycline |
| url | https://www.mdpi.com/2079-6382/9/10/654 |
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