Reversal of rivaroxaban anticoagulant effect by prothrombin complex concentrates: which dose is sufficient to restore normal thrombin generation?
Abstract Rivaroxaban has the most available data to support the use of prothrombin complex concentrates (PCC) as a reversal agent. However, PCC might increase the incidence of thrombotic events by shifting the haemostatic balance towards hypercoagulability. We assessed the in vitro efficacy and safe...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-08-01
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| Series: | Thrombosis Journal |
| Online Access: | http://link.springer.com/article/10.1186/s12959-020-00228-9 |
| _version_ | 1818341491185025024 |
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| author | Lorine Giffard-Quillon Helene Desmurs-Clavel Claire Grange Yohann Jourdy Yesim Dargaud |
| author_facet | Lorine Giffard-Quillon Helene Desmurs-Clavel Claire Grange Yohann Jourdy Yesim Dargaud |
| author_sort | Lorine Giffard-Quillon |
| collection | DOAJ |
| description | Abstract Rivaroxaban has the most available data to support the use of prothrombin complex concentrates (PCC) as a reversal agent. However, PCC might increase the incidence of thrombotic events by shifting the haemostatic balance towards hypercoagulability. We assessed the in vitro efficacy and safety of three 4-factor PCCs for reversing rivaroxaban anticoagulant effect. Our in vitro finding indicates that 4-factor PCCs at the dose of 25 U.kg− 1 may be sufficient to reverse rivaroxaban anticoagulant effect. |
| first_indexed | 2024-12-13T15:59:38Z |
| format | Article |
| id | doaj.art-877354940b3444fc9ec6ad545249ac69 |
| institution | Directory Open Access Journal |
| issn | 1477-9560 |
| language | English |
| last_indexed | 2024-12-13T15:59:38Z |
| publishDate | 2020-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Thrombosis Journal |
| spelling | doaj.art-877354940b3444fc9ec6ad545249ac692022-12-21T23:39:13ZengBMCThrombosis Journal1477-95602020-08-011811510.1186/s12959-020-00228-9Reversal of rivaroxaban anticoagulant effect by prothrombin complex concentrates: which dose is sufficient to restore normal thrombin generation?Lorine Giffard-Quillon0Helene Desmurs-Clavel1Claire Grange2Yohann Jourdy3Yesim Dargaud4GEMMAT Groupe d’Etude Multidisciplinaire en Maladies ThrombotiquesGEMMAT Groupe d’Etude Multidisciplinaire en Maladies ThrombotiquesGEMMAT Groupe d’Etude Multidisciplinaire en Maladies ThrombotiquesLaboratoire d’Hematologie, Groupement Hospitalier Est, Hospices Civils de LyonGEMMAT Groupe d’Etude Multidisciplinaire en Maladies ThrombotiquesAbstract Rivaroxaban has the most available data to support the use of prothrombin complex concentrates (PCC) as a reversal agent. However, PCC might increase the incidence of thrombotic events by shifting the haemostatic balance towards hypercoagulability. We assessed the in vitro efficacy and safety of three 4-factor PCCs for reversing rivaroxaban anticoagulant effect. Our in vitro finding indicates that 4-factor PCCs at the dose of 25 U.kg− 1 may be sufficient to reverse rivaroxaban anticoagulant effect.http://link.springer.com/article/10.1186/s12959-020-00228-9 |
| spellingShingle | Lorine Giffard-Quillon Helene Desmurs-Clavel Claire Grange Yohann Jourdy Yesim Dargaud Reversal of rivaroxaban anticoagulant effect by prothrombin complex concentrates: which dose is sufficient to restore normal thrombin generation? Thrombosis Journal |
| title | Reversal of rivaroxaban anticoagulant effect by prothrombin complex concentrates: which dose is sufficient to restore normal thrombin generation? |
| title_full | Reversal of rivaroxaban anticoagulant effect by prothrombin complex concentrates: which dose is sufficient to restore normal thrombin generation? |
| title_fullStr | Reversal of rivaroxaban anticoagulant effect by prothrombin complex concentrates: which dose is sufficient to restore normal thrombin generation? |
| title_full_unstemmed | Reversal of rivaroxaban anticoagulant effect by prothrombin complex concentrates: which dose is sufficient to restore normal thrombin generation? |
| title_short | Reversal of rivaroxaban anticoagulant effect by prothrombin complex concentrates: which dose is sufficient to restore normal thrombin generation? |
| title_sort | reversal of rivaroxaban anticoagulant effect by prothrombin complex concentrates which dose is sufficient to restore normal thrombin generation |
| url | http://link.springer.com/article/10.1186/s12959-020-00228-9 |
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