Attenuation of Bluetongue Virus (BTV) in an <i>in ovo</i> Model Is Related to the Changes of Viral Genetic Diversity of Cell-Culture Passaged BTV

Attenuation of Bluetongue Virus (BTV) in an <i>in ovo</i> Model Is Related to the Changes of Viral Genetic Diversity of Cell-Culture Passaged BTV

The embryonated chicken egg (ECE) is routinely used for the laboratory isolation and adaptation of Bluetongue virus (BTV) in vitro. However, its utility as an alternate animal model has not been fully explored. In this paper, we evaluated the pathogenesis of BTV <i>in ovo</i> using a pat...

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Bibliographic Details
Main Authors: Fabian Z. X. Lean, Matthew J. Neave, John R. White, Jean Payne, Teresa Eastwood, Jemma Bergfeld, Antonio Di Rubbo, Vittoria Stevens, Kelly R. Davies, Joanne Devlin, David T. Williams, John Bingham
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Viruses
Subjects:
<i>Bluetongue virus</i>
genetic diversity
attenuation
pathogenicity
immunohistochemistry
Online Access:https://www.mdpi.com/1999-4915/11/5/481

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