Gastrointestinal Perforation after Rituximab Therapy in Mantle Cell Lymphoma: A Case Report
Mantle cell lymphoma (MCL) is a rare form of non-Hodgkin lymphoma (NHL), responsible for 2.8% of all NHL cases within the United States. The majority of patients with MCL present with advanced disease, 10-20% of which have extra-nodal involvement at diagnosis. The gastrointestinal presence of lympho...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2018-11-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/494828 |
| _version_ | 1819168562528387072 |
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| author | Michael Adashek Abigail Chan Adriana Medina |
| author_facet | Michael Adashek Abigail Chan Adriana Medina |
| author_sort | Michael Adashek |
| collection | DOAJ |
| description | Mantle cell lymphoma (MCL) is a rare form of non-Hodgkin lymphoma (NHL), responsible for 2.8% of all NHL cases within the United States. The majority of patients with MCL present with advanced disease, 10-20% of which have extra-nodal involvement at diagnosis. The gastrointestinal presence of lymphoma can lead to gastrointestinal perforation, resulting in significant morbidity from peritonitis and sepsis while prolonging hospitalizations and delaying treatment. In this case we discuss a 55-year-old male with newly diagnosed MCL who developed peritonitis 9 days after initiation of dose reduced rituximab due to gastrointestinal perforation. Although prognostication factors for MCL such as the mantle cell lymphoma international prognostic index (MIPI) score exist, further research is needed to stratify risk factors for morbid treatment complications such as gastrointestinal perforation. |
| first_indexed | 2024-12-22T19:05:35Z |
| format | Article |
| id | doaj.art-8776798ee2b546d8bb687da0ab90776a |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-12-22T19:05:35Z |
| publishDate | 2018-11-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-8776798ee2b546d8bb687da0ab90776a2022-12-21T18:15:50ZengKarger PublishersCase Reports in Oncology1662-65752018-11-0111378479010.1159/000494828494828Gastrointestinal Perforation after Rituximab Therapy in Mantle Cell Lymphoma: A Case ReportMichael AdashekAbigail ChanAdriana MedinaMantle cell lymphoma (MCL) is a rare form of non-Hodgkin lymphoma (NHL), responsible for 2.8% of all NHL cases within the United States. The majority of patients with MCL present with advanced disease, 10-20% of which have extra-nodal involvement at diagnosis. The gastrointestinal presence of lymphoma can lead to gastrointestinal perforation, resulting in significant morbidity from peritonitis and sepsis while prolonging hospitalizations and delaying treatment. In this case we discuss a 55-year-old male with newly diagnosed MCL who developed peritonitis 9 days after initiation of dose reduced rituximab due to gastrointestinal perforation. Although prognostication factors for MCL such as the mantle cell lymphoma international prognostic index (MIPI) score exist, further research is needed to stratify risk factors for morbid treatment complications such as gastrointestinal perforation.https://www.karger.com/Article/FullText/494828Mantle Cell LymphomaGastrointestinal Perforation |
| spellingShingle | Michael Adashek Abigail Chan Adriana Medina Gastrointestinal Perforation after Rituximab Therapy in Mantle Cell Lymphoma: A Case Report Case Reports in Oncology Mantle Cell Lymphoma Gastrointestinal Perforation |
| title | Gastrointestinal Perforation after Rituximab Therapy in Mantle Cell Lymphoma: A Case Report |
| title_full | Gastrointestinal Perforation after Rituximab Therapy in Mantle Cell Lymphoma: A Case Report |
| title_fullStr | Gastrointestinal Perforation after Rituximab Therapy in Mantle Cell Lymphoma: A Case Report |
| title_full_unstemmed | Gastrointestinal Perforation after Rituximab Therapy in Mantle Cell Lymphoma: A Case Report |
| title_short | Gastrointestinal Perforation after Rituximab Therapy in Mantle Cell Lymphoma: A Case Report |
| title_sort | gastrointestinal perforation after rituximab therapy in mantle cell lymphoma a case report |
| topic | Mantle Cell Lymphoma Gastrointestinal Perforation |
| url | https://www.karger.com/Article/FullText/494828 |
| work_keys_str_mv | AT michaeladashek gastrointestinalperforationafterrituximabtherapyinmantlecelllymphomaacasereport AT abigailchan gastrointestinalperforationafterrituximabtherapyinmantlecelllymphomaacasereport AT adrianamedina gastrointestinalperforationafterrituximabtherapyinmantlecelllymphomaacasereport |