Body Composition and Biochemical Parameters of Nutritional Status: Correlation with Health-Related Quality of Life in Patients with Colorectal Cancer
Up to 60% of colorectal cancer (CRC) patients develop malnutrition, affecting treatment effectiveness, increasing toxicity, postoperative complications, hospital stay, and worsening health-related quality of life (HRQOL). This cross-sectional study analyzed data from 48 women and 65 men with CRC. We...
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MDPI AG
2020-07-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/7/2110 |
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| author | Luz-Ma-Adriana Balderas-Peña Faviola González-Barba Brenda-Eugenia Martínez-Herrera Ulises-Rodrigo Palomares-Chacón Oscar Durán-Anguiano Mario Salazar-Páramo Eduardo Gómez-Sánchez Carlos Dávalos-Cobián Arnulfo-Hernán Nava-Zavala Guillermo-Allan Hernández-Chávez Daniel Sat-Muñoz |
| author_facet | Luz-Ma-Adriana Balderas-Peña Faviola González-Barba Brenda-Eugenia Martínez-Herrera Ulises-Rodrigo Palomares-Chacón Oscar Durán-Anguiano Mario Salazar-Páramo Eduardo Gómez-Sánchez Carlos Dávalos-Cobián Arnulfo-Hernán Nava-Zavala Guillermo-Allan Hernández-Chávez Daniel Sat-Muñoz |
| author_sort | Luz-Ma-Adriana Balderas-Peña |
| collection | DOAJ |
| description | Up to 60% of colorectal cancer (CRC) patients develop malnutrition, affecting treatment effectiveness, increasing toxicity, postoperative complications, hospital stay, and worsening health-related quality of life (HRQOL). This cross-sectional study analyzed data from 48 women and 65 men with CRC. We correlated scores of the scales from the questionnaires EORTC (European Organisation for Research and Treatment of Cancer) Quality of Life Questionnaire Core 30 (QLQ)-C30 and Colorectal Cancer module Colorectal 29 (QLQ-CR29) with patients’ body composition and clinical and biochemical indicators of nutritional status. Results: Scores on quality of life were negatively associated with the lymphocyte count (rP = −0.386) and the fat trunk percentage (rP = −0.349) in the women’s group. Scores on the physical and role functioning were inversely associated with the adiposity percentage (rP = −0.486 and rP = −0.411, respectively). In men, total skeletal muscle mass (SMM) was positively associated with emotional functioning (rP = 0.450); the trunk SMM was negatively related to fatigue (rP = −0.586), nausea and vomiting (rP = −0.469), pain (rP = −0.506), and financial difficulties (rP = −0.475); additionally, serum albumin was positively related to physical, emotional, and social functioning scales (rPs = 0.395, 0.453, and 0.363, respectively) and negatively to fatigue (rP = −0.362), nausea and vomiting (rP = −0.387), and appetite loss (rP = −0.347). Among the men, the reduced SMM and biochemical, nutritional parameters were related to low scores on the EORTC QLQ-C30 and QLQ-CR29 functioning scales. In conclusion, in patients with CRC, malnourishment could have a profound effect on the patients’ functionality and QoL (quality of life). |
| first_indexed | 2024-03-10T18:26:49Z |
| format | Article |
| id | doaj.art-8777f4ac321546bc8cd8f71e175cf4de |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T18:26:49Z |
| publishDate | 2020-07-01 |
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| series | Nutrients |
| spelling | doaj.art-8777f4ac321546bc8cd8f71e175cf4de2023-11-20T06:57:36ZengMDPI AGNutrients2072-66432020-07-01127211010.3390/nu12072110Body Composition and Biochemical Parameters of Nutritional Status: Correlation with Health-Related Quality of Life in Patients with Colorectal CancerLuz-Ma-Adriana Balderas-Peña0Faviola González-Barba1Brenda-Eugenia Martínez-Herrera2Ulises-Rodrigo Palomares-Chacón3Oscar Durán-Anguiano4Mario Salazar-Páramo5Eduardo Gómez-Sánchez6Carlos Dávalos-Cobián7Arnulfo-Hernán Nava-Zavala8Guillermo-Allan Hernández-Chávez9Daniel Sat-Muñoz10Unidad de Investigación Biomédica 02, UMAE Hospital de Especialidades (HE), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), 1000 Belisario Domínguez, Colonia Independencia, Guadalajara, Jalisco 44340, MexicoUnidad de Investigación Biomédica 02, UMAE Hospital de Especialidades (HE), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), 1000 Belisario Domínguez, Colonia Independencia, Guadalajara, Jalisco 44340, MexicoUnidad de Investigación Biomédica 02, UMAE Hospital de Especialidades (HE), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), 1000 Belisario Domínguez, Colonia Independencia, Guadalajara, Jalisco 44340, MexicoServicio de Coloproctología, Unidad Médica de Alta Especialidad (UMAE), Hospital de Especialidades (HE), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), 1000 Belisario Domínguez, Colonia Independencia, Guadalajara, Jalisco 44340, MexicoServicio de Coloproctología, Unidad Médica de Alta Especialidad (UMAE), Hospital de Especialidades (HE), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), 1000 Belisario Domínguez, Colonia Independencia, Guadalajara, Jalisco 44340, MexicoAcademia de Inmunología, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdG), 950 Sierra Mojada, Gate 7, Building O, 1st level, Colonia Independencia, Guadalajara, Jalisco 44340, MexicoDivisión de Disciplinas Básicas para Salud, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdG), Sierra Mojada 950, Edificio N, Puerta 1, Planta Baja, Colonia Independencia, Guadalajara, Jalisco 44340, MexicoDepartamento Clínico de Gastroenterología Endoscópica, Unidad Médica de Alta Especialidad (UMAE), Hospital de Especialidades (HE), Centro Médico Nacional de Occidente (CMNO,) Instituto Mexicano del Seguro Social (IMSS), 1000 Belisario Domínguez, Colonia Independencia, Guadalajara, Jalisco 44340, MexicoUnidad de Investigación Biomédica 02, UMAE Hospital de Especialidades (HE), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), 1000 Belisario Domínguez, Colonia Independencia, Guadalajara, Jalisco 44340, MexicoDivisión de Oncología Hematología, UMAE, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, 1000 Belisario Domínguez, Colonia Independencia, Guadalajara, Jalisco 44340, MexicoDepartamento de Morfología, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdG), Cuerpo Académico UDG CA-874 “Ciencias morfológicas en el diagnóstico y tratamiento de la enfermedad”, 950 Sierra Mojada, Gate 7, Building C, 1st level, Colonia Independencia, Guadalajara, Jalisco 44340, MexicoUp to 60% of colorectal cancer (CRC) patients develop malnutrition, affecting treatment effectiveness, increasing toxicity, postoperative complications, hospital stay, and worsening health-related quality of life (HRQOL). This cross-sectional study analyzed data from 48 women and 65 men with CRC. We correlated scores of the scales from the questionnaires EORTC (European Organisation for Research and Treatment of Cancer) Quality of Life Questionnaire Core 30 (QLQ)-C30 and Colorectal Cancer module Colorectal 29 (QLQ-CR29) with patients’ body composition and clinical and biochemical indicators of nutritional status. Results: Scores on quality of life were negatively associated with the lymphocyte count (rP = −0.386) and the fat trunk percentage (rP = −0.349) in the women’s group. Scores on the physical and role functioning were inversely associated with the adiposity percentage (rP = −0.486 and rP = −0.411, respectively). In men, total skeletal muscle mass (SMM) was positively associated with emotional functioning (rP = 0.450); the trunk SMM was negatively related to fatigue (rP = −0.586), nausea and vomiting (rP = −0.469), pain (rP = −0.506), and financial difficulties (rP = −0.475); additionally, serum albumin was positively related to physical, emotional, and social functioning scales (rPs = 0.395, 0.453, and 0.363, respectively) and negatively to fatigue (rP = −0.362), nausea and vomiting (rP = −0.387), and appetite loss (rP = −0.347). Among the men, the reduced SMM and biochemical, nutritional parameters were related to low scores on the EORTC QLQ-C30 and QLQ-CR29 functioning scales. In conclusion, in patients with CRC, malnourishment could have a profound effect on the patients’ functionality and QoL (quality of life).https://www.mdpi.com/2072-6643/12/7/2110nutritional statusbody compositioncolorectal neoplasmsquality of lifepatient-reported outcome measures |
| spellingShingle | Luz-Ma-Adriana Balderas-Peña Faviola González-Barba Brenda-Eugenia Martínez-Herrera Ulises-Rodrigo Palomares-Chacón Oscar Durán-Anguiano Mario Salazar-Páramo Eduardo Gómez-Sánchez Carlos Dávalos-Cobián Arnulfo-Hernán Nava-Zavala Guillermo-Allan Hernández-Chávez Daniel Sat-Muñoz Body Composition and Biochemical Parameters of Nutritional Status: Correlation with Health-Related Quality of Life in Patients with Colorectal Cancer Nutrients nutritional status body composition colorectal neoplasms quality of life patient-reported outcome measures |
| title | Body Composition and Biochemical Parameters of Nutritional Status: Correlation with Health-Related Quality of Life in Patients with Colorectal Cancer |
| title_full | Body Composition and Biochemical Parameters of Nutritional Status: Correlation with Health-Related Quality of Life in Patients with Colorectal Cancer |
| title_fullStr | Body Composition and Biochemical Parameters of Nutritional Status: Correlation with Health-Related Quality of Life in Patients with Colorectal Cancer |
| title_full_unstemmed | Body Composition and Biochemical Parameters of Nutritional Status: Correlation with Health-Related Quality of Life in Patients with Colorectal Cancer |
| title_short | Body Composition and Biochemical Parameters of Nutritional Status: Correlation with Health-Related Quality of Life in Patients with Colorectal Cancer |
| title_sort | body composition and biochemical parameters of nutritional status correlation with health related quality of life in patients with colorectal cancer |
| topic | nutritional status body composition colorectal neoplasms quality of life patient-reported outcome measures |
| url | https://www.mdpi.com/2072-6643/12/7/2110 |
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