Performance of Ultrasound-Guided Core Biopsy Driven by FDG-avid Supraclavicular Lymph Nodes in Patients With Suspected Lung Cancer
ObjectivesUltrasound-guided core biopsy (UGCB) for supraclavicular lymph nodes (SLNs) represents an attractive procedure to obtain tissues for lung cancer confirmation. The aim of the present study is to evaluate the performance of UGCB driven by FDG-avid SLNs, as performed by nuclear medicine physi...
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.803500/full |
| _version_ | 1818752572203204608 |
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| author | Tongtong Wang Junbao Liu Ningning Lv Shi Xuan Lin Bai Bin Ji Shi Gao |
| author_facet | Tongtong Wang Junbao Liu Ningning Lv Shi Xuan Lin Bai Bin Ji Shi Gao |
| author_sort | Tongtong Wang |
| collection | DOAJ |
| description | ObjectivesUltrasound-guided core biopsy (UGCB) for supraclavicular lymph nodes (SLNs) represents an attractive procedure to obtain tissues for lung cancer confirmation. The aim of the present study is to evaluate the performance of UGCB driven by FDG-avid SLNs, as performed by nuclear medicine physicians, in patients with suspected lung cancer.MethodsInstitutional database in our hospital was searched for eligible patients between September 2019 and March 2021. A 3-12 MHz linear probe was used to guide the biopsy process and to ensure that the needle tip was being directed at the metabolically active area that had been indicated by side-by-side PET/CT images. Diagnostic yield, malignancy rate, molecular testing results, and complications were reviewed.ResultsAmong the 54 patients included in this study, definite pathological diagnosis from UGCB specimens was achieved in 53 patients, reaching a diagnostic yield of 98.1% (53/54) and a malignancy rate of 96.2% (51/53). Among the 50 patients confirmed as lung cancer, thirty-eight were spared from further invasive procedures which had been planned. Molecular analyses were adequately performed on all the 38 specimens obtained from non-small cell lung cancer (NSCLS). The positive rate was 36.8% (14/38) for epidermal growth receptor (EGFR) mutation and 31.6% (12/38) for anaplastic lymphoma kinase (ALK) translocation. 28.9% (11/38) of the patients had a tumor proportion score (TPS) ≥ 50% for PD-L1 expression. No complication was observed and the average biopsy time was 15 min.ConclusionsNuclear medicine physicians-performed UGCB driven by FDG-avid SLNs in suspected lung cancer patients could produce a high performance in terms of diagnostic yield, malignancy rate, and molecular analysis, which may obliviate more invasive interventional procedures and lead to fast decisions on subsequent management. |
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| language | English |
| last_indexed | 2024-12-18T04:53:35Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj.art-87788482a8af4ac3917a1f011a1199ca2022-12-21T21:20:21ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-01-01810.3389/fmed.2021.803500803500Performance of Ultrasound-Guided Core Biopsy Driven by FDG-avid Supraclavicular Lymph Nodes in Patients With Suspected Lung CancerTongtong Wang0Junbao Liu1Ningning Lv2Shi Xuan3Lin Bai4Bin Ji5Shi Gao6Department of Nuclear Medicine, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Surgery, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Nuclear Medicine, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Nuclear Medicine, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Nuclear Medicine, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Nuclear Medicine, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Nuclear Medicine, China-Japan Union Hospital of Jilin University, Changchun, ChinaObjectivesUltrasound-guided core biopsy (UGCB) for supraclavicular lymph nodes (SLNs) represents an attractive procedure to obtain tissues for lung cancer confirmation. The aim of the present study is to evaluate the performance of UGCB driven by FDG-avid SLNs, as performed by nuclear medicine physicians, in patients with suspected lung cancer.MethodsInstitutional database in our hospital was searched for eligible patients between September 2019 and March 2021. A 3-12 MHz linear probe was used to guide the biopsy process and to ensure that the needle tip was being directed at the metabolically active area that had been indicated by side-by-side PET/CT images. Diagnostic yield, malignancy rate, molecular testing results, and complications were reviewed.ResultsAmong the 54 patients included in this study, definite pathological diagnosis from UGCB specimens was achieved in 53 patients, reaching a diagnostic yield of 98.1% (53/54) and a malignancy rate of 96.2% (51/53). Among the 50 patients confirmed as lung cancer, thirty-eight were spared from further invasive procedures which had been planned. Molecular analyses were adequately performed on all the 38 specimens obtained from non-small cell lung cancer (NSCLS). The positive rate was 36.8% (14/38) for epidermal growth receptor (EGFR) mutation and 31.6% (12/38) for anaplastic lymphoma kinase (ALK) translocation. 28.9% (11/38) of the patients had a tumor proportion score (TPS) ≥ 50% for PD-L1 expression. No complication was observed and the average biopsy time was 15 min.ConclusionsNuclear medicine physicians-performed UGCB driven by FDG-avid SLNs in suspected lung cancer patients could produce a high performance in terms of diagnostic yield, malignancy rate, and molecular analysis, which may obliviate more invasive interventional procedures and lead to fast decisions on subsequent management.https://www.frontiersin.org/articles/10.3389/fmed.2021.803500/fullultrasound-guided core biopsysupraclavicular lymph nodeslung cancer–diagnosisFDG-PET/CTperformance |
| spellingShingle | Tongtong Wang Junbao Liu Ningning Lv Shi Xuan Lin Bai Bin Ji Shi Gao Performance of Ultrasound-Guided Core Biopsy Driven by FDG-avid Supraclavicular Lymph Nodes in Patients With Suspected Lung Cancer Frontiers in Medicine ultrasound-guided core biopsy supraclavicular lymph nodes lung cancer–diagnosis FDG-PET/CT performance |
| title | Performance of Ultrasound-Guided Core Biopsy Driven by FDG-avid Supraclavicular Lymph Nodes in Patients With Suspected Lung Cancer |
| title_full | Performance of Ultrasound-Guided Core Biopsy Driven by FDG-avid Supraclavicular Lymph Nodes in Patients With Suspected Lung Cancer |
| title_fullStr | Performance of Ultrasound-Guided Core Biopsy Driven by FDG-avid Supraclavicular Lymph Nodes in Patients With Suspected Lung Cancer |
| title_full_unstemmed | Performance of Ultrasound-Guided Core Biopsy Driven by FDG-avid Supraclavicular Lymph Nodes in Patients With Suspected Lung Cancer |
| title_short | Performance of Ultrasound-Guided Core Biopsy Driven by FDG-avid Supraclavicular Lymph Nodes in Patients With Suspected Lung Cancer |
| title_sort | performance of ultrasound guided core biopsy driven by fdg avid supraclavicular lymph nodes in patients with suspected lung cancer |
| topic | ultrasound-guided core biopsy supraclavicular lymph nodes lung cancer–diagnosis FDG-PET/CT performance |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.803500/full |
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