Recurrent Guillain-Barré syndrome presenting as pharyngeal-cervical-brachial variant with three species of ganglioside antibodies:case report
Abstract Background Guillain-Barré syndrome (GBS) is generally considered to be monophasic, and recurrent GBS (RGBS) is very rare. Pharyngeal-cervical-brachial (PCB) is a less common variant of GBS. There have been no cases reported describing RGBS showing different phenotype presenting as PCB varia...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | BMC Neurology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12883-022-02955-0 |
| _version_ | 1811315289162252288 |
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| author | Haihui Luan Peng Zhang Mingqing Zhen Mei Li Xiaowei Wang Jianghua Xu |
| author_facet | Haihui Luan Peng Zhang Mingqing Zhen Mei Li Xiaowei Wang Jianghua Xu |
| author_sort | Haihui Luan |
| collection | DOAJ |
| description | Abstract Background Guillain-Barré syndrome (GBS) is generally considered to be monophasic, and recurrent GBS (RGBS) is very rare. Pharyngeal-cervical-brachial (PCB) is a less common variant of GBS. There have been no cases reported describing RGBS showing different phenotype presenting as PCB variant with three species of ganglioside antibodies. Case presentation We report a case of a 77-year-old female patient with GT1a, GD1a and sulfatide-seropositive PCB-GBS after prior episode of AMAN-GBS 13 years ago. Our patient showed oropharyngeal and cervicobrachial weakness associated with areflexia in the upper limbs and partially improved after 5 days of IVIG and physiotherapy. Conclusion This study reports a rare case characterized as recurrent GBS after a long period, showing different phenotypes in different episodes with three different species of ganglioside antibodies. Further studies are required to obtain better understanding of RGBS and PCB variant. |
| first_indexed | 2024-04-13T11:27:39Z |
| format | Article |
| id | doaj.art-877a2fd585ba483a818e328e26d89782 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-04-13T11:27:39Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-877a2fd585ba483a818e328e26d897822022-12-22T02:48:39ZengBMCBMC Neurology1471-23772022-11-012211310.1186/s12883-022-02955-0Recurrent Guillain-Barré syndrome presenting as pharyngeal-cervical-brachial variant with three species of ganglioside antibodies:case reportHaihui Luan0Peng Zhang1Mingqing Zhen2Mei Li3Xiaowei Wang4Jianghua Xu5Department of Neurology, YEDA HospitalDepartment of Neurology, YEDA HospitalDepartment of Neurology, YEDA HospitalDepartment of Neurology, YEDA HospitalDepartment of Neurology, YEDA HospitalDepartment of Neurology, YEDA HospitalAbstract Background Guillain-Barré syndrome (GBS) is generally considered to be monophasic, and recurrent GBS (RGBS) is very rare. Pharyngeal-cervical-brachial (PCB) is a less common variant of GBS. There have been no cases reported describing RGBS showing different phenotype presenting as PCB variant with three species of ganglioside antibodies. Case presentation We report a case of a 77-year-old female patient with GT1a, GD1a and sulfatide-seropositive PCB-GBS after prior episode of AMAN-GBS 13 years ago. Our patient showed oropharyngeal and cervicobrachial weakness associated with areflexia in the upper limbs and partially improved after 5 days of IVIG and physiotherapy. Conclusion This study reports a rare case characterized as recurrent GBS after a long period, showing different phenotypes in different episodes with three different species of ganglioside antibodies. Further studies are required to obtain better understanding of RGBS and PCB variant.https://doi.org/10.1186/s12883-022-02955-0Guillain-Barré syndromePharyngeal-cervical-brachial variantAnti-ganglioside antibodyRecurrence |
| spellingShingle | Haihui Luan Peng Zhang Mingqing Zhen Mei Li Xiaowei Wang Jianghua Xu Recurrent Guillain-Barré syndrome presenting as pharyngeal-cervical-brachial variant with three species of ganglioside antibodies:case report BMC Neurology Guillain-Barré syndrome Pharyngeal-cervical-brachial variant Anti-ganglioside antibody Recurrence |
| title | Recurrent Guillain-Barré syndrome presenting as pharyngeal-cervical-brachial variant with three species of ganglioside antibodies:case report |
| title_full | Recurrent Guillain-Barré syndrome presenting as pharyngeal-cervical-brachial variant with three species of ganglioside antibodies:case report |
| title_fullStr | Recurrent Guillain-Barré syndrome presenting as pharyngeal-cervical-brachial variant with three species of ganglioside antibodies:case report |
| title_full_unstemmed | Recurrent Guillain-Barré syndrome presenting as pharyngeal-cervical-brachial variant with three species of ganglioside antibodies:case report |
| title_short | Recurrent Guillain-Barré syndrome presenting as pharyngeal-cervical-brachial variant with three species of ganglioside antibodies:case report |
| title_sort | recurrent guillain barre syndrome presenting as pharyngeal cervical brachial variant with three species of ganglioside antibodies case report |
| topic | Guillain-Barré syndrome Pharyngeal-cervical-brachial variant Anti-ganglioside antibody Recurrence |
| url | https://doi.org/10.1186/s12883-022-02955-0 |
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